Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0016020 | cellular_component | membrane |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue QJJ A 401 |
| Chain | Residue |
| A | SER10 |
| A | ILE118 |
| A | ASP228 |
| A | SER229 |
| A | GLY230 |
| A | THR232 |
| A | HOH527 |
| A | HOH697 |
| A | GLY11 |
| A | GLN12 |
| A | GLY13 |
| A | ASP32 |
| A | TYR71 |
| A | PHE108 |
| A | ILE110 |
| A | TRP115 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue QJM A 402 |
| Chain | Residue |
| A | HIS362 |
| A | ASP363 |
| A | GLU364 |
| A | PHE365 |
| A | ARG366 |
| A | THR367 |
| A | HOH675 |
| A | HOH720 |
| A | HOH1018 |
| B | GLN55 |
| B | ARG297 |
| B | GLU371 |
| B | GLY372 |
| B | PRO373 |
| B | PHE374 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | ASP318 |
| A | HOH581 |
| A | HOH647 |
| A | HOH719 |
| B | SER58 |
| B | THR59 |
| B | ARG61 |
| B | ARG96 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 404 |
| Chain | Residue |
| A | ARG50 |
| A | TYR51 |
| A | GLN53 |
| A | HOH865 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 405 |
| Chain | Residue |
| A | LYS9 |
| A | GLY11 |
| A | GLN12 |
| A | ARG307 |
| A | LYS321 |
| A | HOH533 |
| A | HOH534 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | binding site for residue QJJ B 401 |
| Chain | Residue |
| B | SER10 |
| B | GLY11 |
| B | GLN12 |
| B | GLY13 |
| B | ASP32 |
| B | TYR71 |
| B | ILE110 |
| B | ILE118 |
| B | ASP228 |
| B | SER229 |
| B | GLY230 |
| B | THR232 |
| B | HOH597 |
| B | HOH832 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | binding site for residue QJJ B 402 |
| Chain | Residue |
| A | SER164 |
| A | GLU165 |
| A | HOH598 |
| B | THR82 |
| B | ARG96 |
| B | ASN98 |
| B | SER132 |
| B | GLU134 |
| B | SER139 |
| B | LYS142 |
| B | HOH531 |
| B | HOH735 |
| B | HOH772 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | binding site for residue QJJ B 403 |
| Chain | Residue |
| A | THR82 |
| A | ARG96 |
| A | ASN98 |
| A | SER132 |
| A | GLU134 |
| A | SER139 |
| A | LYS142 |
| A | HOH632 |
| B | ASN162 |
| B | SER164 |
| B | GLU165 |
| B | HOH553 |
| B | HOH572 |
| B | HOH740 |
| site_id | AC9 |
| Number of Residues | 16 |
| Details | binding site for residue QJM B 404 |
| Chain | Residue |
| B | ASP363 |
| B | GLU364 |
| B | PHE365 |
| B | ARG366 |
| B | THR367 |
| B | HOH619 |
| B | HOH644 |
| B | HOH668 |
| A | GLN55 |
| A | ARG297 |
| A | GLU371 |
| A | GLY372 |
| A | PRO373 |
| A | PHE374 |
| A | HOH1033 |
| B | HIS362 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 405 |
| Chain | Residue |
| A | SER58 |
| A | THR59 |
| A | ARG61 |
| A | ARG96 |
| B | ASP318 |
| B | HOH567 |
| B | HOH609 |
| B | HOH682 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 406 |
| Chain | Residue |
| B | ARG50 |
| B | TYR51 |
| B | HOH864 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 407 |
| Chain | Residue |
| A | LYS239 |
| B | ASP106 |
| B | LYS107 |
| B | HOH514 |
| B | HOH533 |
| B | HOH616 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 408 |
| Chain | Residue |
| B | LYS9 |
| B | GLY11 |
| B | GLN12 |
| B | ARG307 |
| B | LYS321 |
| B | HOH527 |
| B | HOH556 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV |
| Chain | Residue | Details |
| A | ILE29-VAL40 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 341 |
| Details | Domain: {"description":"Peptidase A1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01103","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17425515","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19011241","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
