6UVH
Crystal structure of BCL-XL bound to compound 15: (R)-2-(3-(2-((4'-Chloro-[1,1'-biphenyl]-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonyl)-3-(4-methylbenzyl)ureido)-3-((cyclohexylmethyl)sulfonyl)propanoic acid
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Bcl-2-like protein 1 | polymer | 158 | 17918.0 | 4 | UniProt (Q07817) Pfam (PF02180) Pfam (PF00452) In PDB | Homo sapiens (Human) | Bcl2-L-1,Apoptosis regulator Bcl-X |
2 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
3 | A, D | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
4 | A, B, C, D | (R)-2-(3-(2-((4'-Chloro-[1,1'-biphenyl]-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonyl)-3-(4-methylbenzyl)ureido)-3-((cyclohexylmethyl)sulfonyl)propanoic acid | non-polymer | 756.3 | 4 | Chemie (QHJ) | |||
5 | water | water | 18.0 | 96 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 26 (UniProt: Q07817)
A, B, C, D: 83 - 209 (UniProt: Q07817)
PDB | External Database | Details |
---|---|---|
Gly -5 | - | expression tag |
Pro -4 | - | expression tag |
Leu -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 71671.8 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 3279.6 | |
All* | Total formula weight | 74951.4 |