6UUQ
Structure of Calcineurin bound to RCAN1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | polymer | 316 | 36467.7 | 1 | UniProt (Q08209) Pfam (PF00149) | Homo sapiens (Human) | CAM-PRP catalytic subunit,Calmodulin-dependent calcineurin A subunit alpha isoform |
| 2 | B (B) | Calcipressin-1 | polymer | 40 | 4343.8 | 1 | UniProt (P53805) | Homo sapiens (Human) | Adapt78,Down syndrome critical region protein 1,Myocyte-enriched calcineurin-interacting protein 1,MCIP1,Regulator of calcineurin 1 |
| 3 | C, D (A) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 4 | E (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | F (A) | FE (III) ION | non-polymer | 55.8 | 1 | Chemie (FE) | |||
| 6 | G, H (A, B) | water | water | 18.0 | 313 | Chemie (HOH) |
Sequence modifications
A: 26 - 339 (UniProt: Q08209)
B: 128 - 164 (UniProt: P53805)
| PDB | External Database | Details |
|---|---|---|
| Met 24 | - | expression tag |
| Gly 25 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 125 | - | expression tag |
| His 126 | - | expression tag |
| Met 127 | - | expression tag |
| Ile 158 | Val 158 | engineered mutation |
| Thr 159 | His 159 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 40811.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 311.2 | |
| All* | Total formula weight | 41122.7 |
