6UUQ

Structure of Calcineurin bound to RCAN1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	polymer	316	36467.7	1	UniProt (Q08209) Pfam (PF00149) In PDB	Homo sapiens (Human)	CAM-PRP catalytic subunit,Calmodulin-dependent calcineurin A subunit alpha isoform
2	B	Calcipressin-1	polymer	40	4343.8	1	UniProt (P53805) In PDB	Homo sapiens (Human)	Adapt78,Down syndrome critical region protein 1,Myocyte-enriched calcineurin-interacting protein 1,MCIP1,Regulator of calcineurin 1
3	A	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
4	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
5	A	FE (III) ION	non-polymer		55.8	1	Chemie (FE)
6		water	water		18.0	313	Chemie (HOH)

Sequence modifications

A: 26 - 339 (UniProt: Q08209)

PDB	External Database	Details
Met 24	-	expression tag
Gly 25	-	expression tag

B: 128 - 164 (UniProt: P53805)

PDB	External Database	Details
Gly 125	-	expression tag
His 126	-	expression tag
Met 127	-	expression tag
Ile 158	Val 158	engineered mutation
Thr 159	His 159	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	40811.5
Non-Polymers*	Number of molecules	4
	Total formula weight	311.2
All*	Total formula weight	41122.7

*Water molecules are not included.