6URG
Cryo-EM structure of human CPSF160-WDR33-CPSF30-CPSF100 PIM complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Cleavage and polyadenylation specificity factor subunit 1 | polymer | 1443 | 161074.2 | 1 | UniProt (Q10570) Pfam (PF10433) Pfam (PF03178) In PDB | Homo sapiens (Human) | Cleavage and polyadenylation specificity factor 160 kDa subunit, CPSF 160 kDa subunit |
| 2 | B | pre-mRNA 3' end processing protein WDR33 | polymer | 587 | 67546.8 | 1 | UniProt (Q9C0J8) Pfam (PF00400) In PDB | Homo sapiens (Human) | WD repeat-containing protein 33, WD repeat-containing protein WDC146 |
| 3 | C | Cleavage and polyadenylation specificity factor subunit 4 | polymer | 250 | 28417.9 | 1 | UniProt (O95639) Pfam (PF00642) Pfam (PF00098) Pfam (PF15663) In PDB | Homo sapiens (Human) | Cleavage and polyadenylation specificity factor 30 kDa subunit,CPSF 30 kDa subunit,NS1 effector domain-binding protein 1,Neb-1,No arches homolog |
| 4 | F | Cleavage and polyadenylation specificity factor subunit 2 | polymer | 782 | 88597.7 | 1 | UniProt (Q9P2I0) Pfam (PF16661) Pfam (PF10996) Pfam (PF07521) Pfam (PF13299) In PDB | Homo sapiens (Human) | Cleavage and polyadenylation specificity factor 100 kDa subunit,CPSF 100 kDa subunit |
| 5 | C | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
B: 1 - 572 (UniProt: Q9C0J8)
C: 1 - 244 (UniProt: O95639)
| PDB | External Database | Details |
|---|---|---|
| Met -14 | - | expression tag |
| Gly -13 | - | expression tag |
| Ser -12 | - | expression tag |
| Ser -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| Ser -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Val 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| His 245 | - | expression tag |
| His 246 | - | expression tag |
| His 247 | - | expression tag |
| His 248 | - | expression tag |
| His 249 | - | expression tag |
| His 250 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 345636.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 345702.1 |
