6UQQ

Crystal Structure of GTPase Domain of Human Septin 7 / Septin 3 T282Y Heterocomplex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Septin-7	polymer	285	32757.4	2	UniProt (Q16181) Pfam (PF00735)	Homo sapiens (Human)	CDC10 protein homolog
2	C, D (C, D)	Neuronal-specific septin-3	polymer	293	33918.6	2	UniProt (Q9UH03) Pfam (PF00735)	Homo sapiens (Human)
3	E, F, G, H (A, B, C, D)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	4	Chemie (GDP)
4	I, J, K, L (A, B, C, D)	water	water		18.0	150	Chemie (HOH)

Sequence modifications

A, B: 48 - 318 (UniProt: Q16181)

PDB	External Database	Details
Met 34	-	expression tag
Gly 35	-	expression tag
Ser 36	-	expression tag
Ser 37	-	expression tag
His 38	-	expression tag
His 39	-	expression tag
His 40	-	expression tag
His 41	-	expression tag
His 42	-	expression tag
His 43	-	expression tag
Ser 44	-	expression tag
Gln 45	-	expression tag
Asp 46	-	expression tag
Pro 47	-	expression tag

C, D: 59 - 350 (UniProt: Q9UH03)

PDB	External Database	Details
Met 58	-	initiating methionine
Tyr 282	Thr 282	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	133351.9
Non-Polymers*	Number of molecules	4
	Total formula weight	1772.8
All*	Total formula weight	135124.7

*Water molecules are not included.