6UQQ

Crystal Structure of GTPase Domain of Human Septin 7 / Septin 3 T282Y Heterocomplex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005525	molecular_function	GTP binding
B	0005525	molecular_function	GTP binding
C	0005525	molecular_function	GTP binding
D	0005525	molecular_function	GTP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue GDP A 401

Chain	Residue
A	SER59
A	ASP197
A	VAL249
A	GLY250
A	ARG265
A	TYR267
A	HOH527
A	HOH541
A	HOH549
A	GLY60
A	LEU61
A	GLY62
A	LYS63
A	SER64
A	THR65
A	SER84
A	LYS195

---

site_id	AC2
Number of Residues	12
Details	binding site for residue GDP B 401

Chain	Residue
B	GLY60
B	LEU61
B	GLY62
B	LYS63
B	SER64
B	THR65
B	LYS195
B	ASP197
B	VAL249
B	GLY250
B	ARG265
B	TYR267

---

site_id	AC3
Number of Residues	13
Details	binding site for residue GDP C 401

Chain	Residue
C	GLY71
C	LEU72
C	GLY73
C	LYS74
C	SER75
C	THR76
C	LYS89
C	LYS208
C	ASP210
C	VAL264
C	GLY265
C	ARG280
C	TYR282

---

site_id	AC4
Number of Residues	13
Details	binding site for residue GDP D 401

Chain	Residue
D	SER70
D	GLY71
D	LEU72
D	GLY73
D	LYS74
D	SER75
D	THR76
D	LYS208
D	ASP210
D	VAL264
D	GLY265
D	ARG280
D	TYR282

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269|PubMed:23163726

Chain	Residue	Details
C	GLY68
D	ARG280
C	THR102
C	LYS208
C	GLY265
C	ARG280
D	GLY68
D	THR102
D	LYS208
D	GLY265

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9WU34

Chain	Residue	Details
C	SER91
B	GLN266
D	SER91
A	ALA196
A	SER251
A	GLN266
B	VAL91
B	PHE117
B	ALA196
B	SER251

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O55131

Chain	Residue	Details
A	PRO78
B	PRO78

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	ASP229
B	ASP229

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