6UQI
Crystal structure of Q38A human DNA polymerase eta bound with 8-oxoadenine (oxoA) and non-hydrolyzable dGTP analog (dGTP*)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA polymerase eta | polymer | 435 | 48560.7 | 1 | UniProt (Q9Y253) Pfam (PF00817) Pfam (PF21704) Pfam (PF11799) | Homo sapiens (Human) | RAD30 homolog A,Xeroderma pigmentosum variant type protein |
| 2 | B (T) | DNA (5'-D(*CP*AP*TP*(A38)P*AP*TP*GP*AP*CP*GP*CP*T)-3') | polymer | 12 | 3662.4 | 1 | Homo sapiens | ||
| 3 | C (P) | DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3') | polymer | 8 | 2426.6 | 1 | Homo sapiens | ||
| 4 | D (A) | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine | non-polymer | 506.2 | 1 | Chemie (XG4) | |||
| 5 | E, F (A) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 6 | G, H (A, P) | water | water | 18.0 | 42 | Chemie (HOH) |
Sequence modifications
A: 1 - 432 (UniProt: Q9Y253)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| His 0 | - | expression tag |
| Ala 38 | Gln 38 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 54649.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 616.1 | |
| All* | Total formula weight | 55265.7 |
