6UPQ

Crystal Structure of GTPase Domain of Human Septin 2 / Septin 11 Heterocomplex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Septin-2	polymer	274	31691.3	1	UniProt (Q15019) Pfam (PF00735)	Homo sapiens (Human)	Neural precursor cell expressed developmentally down-regulated protein 5,NEDD-5
2	B (B)	Septin-11	polymer	293	33649.4	1	UniProt (Q9NVA2) Pfam (PF00735)	Homo sapiens (Human)
3	C (A)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	1	Chemie (GDP)
4	D (B)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	1	Chemie (GTP)
5	E (B)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6	F, G (A, B)	water	water		18.0	498	Chemie (HOH)

Sequence modifications

A: 36 - 308 (UniProt: Q15019)

PDB	External Database	Details
Met 35	-	initiating methionine

B: 40 - 306 (UniProt: Q9NVA2)

PDB	External Database	Details
Met 14	-	initiating methionine
Gly 15	-	expression tag
Ser 16	-	expression tag
Ser 17	-	expression tag
His 18	-	expression tag
His 19	-	expression tag
His 20	-	expression tag
His 21	-	expression tag
His 22	-	expression tag
His 23	-	expression tag
Ser 24	-	expression tag
Gln 25	-	expression tag
Asp 26	-	expression tag
Pro 27	-	expression tag
Asn 28	-	expression tag
Ser 29	-	expression tag
Ser 30	-	expression tag
Ser 31	-	expression tag
Ala 32	-	expression tag
Arg 33	-	expression tag
Leu 34	-	expression tag
Gln 35	-	expression tag
Val 36	-	expression tag
Asp 37	-	expression tag
Lys 38	-	expression tag
Leu 39	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65340.7
Non-Polymers*	Number of molecules	3
	Total formula weight	990.7
All*	Total formula weight	66331.4

*Water molecules are not included.