6UPQ

Crystal Structure of GTPase Domain of Human Septin 2 / Septin 11 Heterocomplex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005525	molecular_function	GTP binding
A	0051301	biological_process	cell division
B	0005525	molecular_function	GTP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	binding site for residue GDP A 1401

Chain	Residue
A	GLY47
A	VAL240
A	GLY241
A	ARG256
A	TYR258
A	HOH1504
A	HOH1535
A	HOH1572
A	HOH1592
A	HOH1602
A	HOH1649
A	LEU48
B	THR157
B	HIS159
B	THR187
B	GLU192
B	HOH700
A	GLY49
A	LYS50
A	SER51
A	THR52
A	ARG66
A	LYS183
A	ASP185

---

site_id	AC2
Number of Residues	28
Details	binding site for residue GTP B 500

Chain	Residue
A	HIS158
A	THR186
A	GLU191
A	HOH1529
A	HOH1639
B	GLY51
B	ILE52
B	GLY53
B	LYS54
B	SER55
B	THR56
B	PRO70
B	ALA71
B	LYS184
B	ASP186
B	VAL237
B	GLY238
B	ARG253
B	TYR255
B	MG501
B	HOH635
B	HOH636
B	HOH639
B	HOH658
B	HOH662
B	HOH673
B	HOH743
B	HOH745

---

site_id	AC3
Number of Residues	5
Details	binding site for residue MG B 501

Chain	Residue
B	SER55
B	GTP500
B	HOH639
B	HOH658
B	HOH662

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Region: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01056","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Region: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01056","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Region: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01056","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Region: {"description":"Important for dimerization"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	17
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Site: {"description":"Important for dimerization"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15150837","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19165576","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18088087","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18318008","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---