6UP8
Triosephosphate isomerase deficiency: Effect of F240L mutation on enzyme structure
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Triosephosphate isomerase | polymer | 252 | 26949.7 | 2 | UniProt (P60174) Pfam (PF00121) | Homo sapiens (Human) | TIM,Methylglyoxal synthase,Triose-phosphate isomerase |
| 2 | C, D, E, F, G (A, B) | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 5 | Chemie (IPA) | |||
| 3 | H, I (A, B) | water | water | 18.0 | 308 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 248 (UniProt: P60174)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
| Leu 240 | Phe 278 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 53899.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 300.5 | |
| All* | Total formula weight | 54199.9 |
