6UO8
Human metabotropic GABA(B) receptor bound to agonist SKF97541 and positive allosteric modulator GS39783
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Gamma-aminobutyric acid type B receptor subunit 1 | polymer | 762 | 86451.0 | 1 | UniProt (Q9UBS5) Pfam (PF01094) Pfam (PF00003) In PDB | Homo sapiens (Human) | Gb1 |
| 2 | B | Gamma-aminobutyric acid type B receptor subunit 2 | polymer | 779 | 88200.8 | 1 | UniProt (O75899) Pfam (PF01094) Pfam (PF00003) Pfam (PF18455) In PDB | Homo sapiens (Human) | Gb2,G-protein coupled receptor 51,HG20 |
| 3 | C, E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 4 | D | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 5 | A | (R)-(3-aminopropyl)methylphosphinic acid | non-polymer | 137.1 | 1 | Chemie (QD7) | |||
| 6 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 7 | A | N~4~,N~6~-dicyclopentyl-2-(methylsulfanyl)-5-nitropyrimidine-4,6-diamine | non-polymer | 337.4 | 1 | Chemie (QDA) |
Sequence modifications
A: 165 - 919 (UniProt: Q9UBS5)
| PDB | External Database | Details |
|---|---|---|
| Gly 164 | - | expression tag |
| Leu 920 | - | expression tag |
| Glu 921 | - | expression tag |
| Val 922 | - | expression tag |
| Leu 923 | - | expression tag |
| Phe 924 | - | expression tag |
| Gln 925 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 174651.8 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1435.3 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1801.8 | |
| All* | Total formula weight | 177889.0 |
