6UO8

Human metabotropic GABA(B) receptor bound to agonist SKF97541 and positive allosteric modulator GS39783

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004965	molecular_function	G protein-coupled GABA receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane
B	0004930	molecular_function	G protein-coupled receptor activity
B	0004965	molecular_function	G protein-coupled GABA receptor activity
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00981
Number of Residues	11
Details	G_PROTEIN_RECEP_F3_3 G-protein coupled receptors family 3 signature 3. LNDSKyIGMSV

Chain	Residue	Details
B	LEU686-VAL696

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	490
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
B	TRP42-SER483
B	VAL544-THR551
B	ASP619-THR654
B	THR713-GLN720

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	TRANSMEM: Helical; Name=1 => ECO:0000255

Chain	Residue	Details
B	ILE484-ILE504
A	HIS689-LEU710
A	GLU790-ALA804

---

site_id	SWS_FT_FI3
Number of Residues	56
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
B	LYS505-LEU522
B	ALA573-LEU597
B	TRP676-TYR691

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	TRANSMEM: Helical; Name=2 => ECO:0000255

Chain	Residue	Details
B	ILE523-PHE543
A	ASP732-THR768
A	LEU826-ALA833

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	TRANSMEM: Helical; Name=3 => ECO:0000255

Chain	Residue	Details
B	LEU552-PHE572

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	TRANSMEM: Helical; Name=4 => ECO:0000255

Chain	Residue	Details
B	LEU598-VAL618

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site_id	SWS_FT_FI7
Number of Residues	20
Details	TRANSMEM: Helical; Name=5 => ECO:0000255

Chain	Residue	Details
B	ILE655-ALA675

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site_id	SWS_FT_FI8
Number of Residues	20
Details	TRANSMEM: Helical; Name=6 => ECO:0000255

Chain	Residue	Details
B	ILE692-LEU712

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site_id	SWS_FT_FI9
Number of Residues	20
Details	TRANSMEM: Helical; Name=7 => ECO:0000255

Chain	Residue	Details
B	PHE721-VAL741

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q80T41

Chain	Residue	Details
B	SER776
B	SER779
A	HIS287

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q80T41

Chain	Residue	Details
B	THR819

---

site_id	SWS_FT_FI12
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22660477

Chain	Residue	Details
B	ASN90
B	ASN389
B	ASN453

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN298

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site_id	SWS_FT_FI14
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22660477, ECO:0000269|PubMed:24305054

Chain	Residue	Details
B	ASN404
A	ASN502
A	ASN514

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24305054

Chain	Residue	Details
A	ASN440
A	ASN482

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