6UNQ

Kinase domain of ALK2-K493A with AMPPNP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Activin receptor type-1	polymer	330	38117.4	1	UniProt (Q04771) Pfam (PF00069)	Homo sapiens (Human)	Activin receptor type I,ACTR-I,Activin receptor-like kinase 2,ALK-2,Serine/threonine-protein kinase receptor R1,SKR1,TGF-B superfamily receptor type I,TSR-I
2	B (A)	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	1	Chemie (ANP)
3	C, D, E, F (A)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
4	G (A)	water	water		18.0	3	Chemie (HOH)

Sequence modifications

A: 201 - 499 (UniProt: Q04771)

PDB	External Database	Details
Met 170	-	initiating methionine
Ser 171	-	expression tag
Tyr 172	-	expression tag
Tyr 173	-	expression tag
His 174	-	expression tag
His 175	-	expression tag
His 176	-	expression tag
His 177	-	expression tag
His 178	-	expression tag
His 179	-	expression tag
His 180	-	expression tag
His 181	-	expression tag
His 182	-	expression tag
His 183	-	expression tag
Asp 184	-	expression tag
Tyr 185	-	expression tag
Asp 186	-	expression tag
Ile 187	-	expression tag
Pro 188	-	expression tag
Thr 189	-	expression tag
Thr 190	-	expression tag
Glu 191	-	expression tag
Asn 192	-	expression tag
Leu 193	-	expression tag
Tyr 194	-	expression tag
Phe 195	-	expression tag
Gln 196	-	expression tag
Gly 197	-	expression tag
Ala 198	-	expression tag
Met 199	-	expression tag
Gly 200	-	expression tag
Ala 493	Lys 493	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	38117.4
Non-Polymers*	Number of molecules	5
	Total formula weight	603.4
All*	Total formula weight	38720.9

*Water molecules are not included.