6UMT

High-affinity human PD-1 PD-L2 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Programmed cell death protein 1	polymer	140	15429.4	1	UniProt (Q15116) Pfam (PF07686)	Homo sapiens (Human)	hPD-1
2	B (B)	Programmed cell death 1 ligand 2	polymer	123	13949.0	1	UniProt (Q9BQ51)	Homo sapiens (Human)	Programmed death ligand 2,Butyrophilin B7-DC,B7-DC
3	C (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
4	D, E (A, B)	water	water		18.0	125	Chemie (HOH)

Sequence modifications

A: 33 - 150 (UniProt: Q15116)

PDB	External Database	Details
Met 14	-	expression tag
Gly 15	-	expression tag
Trp 16	-	expression tag
Ser 17	-	expression tag
Cys 18	-	expression tag
Ile 19	-	expression tag
Ile 20	-	expression tag
Leu 21	-	expression tag
Phe 22	-	expression tag
Leu 23	-	expression tag
Val 24	-	expression tag
Ala 25	-	expression tag
Thr 26	-	expression tag
Ala 27	-	expression tag
Thr 28	-	expression tag
Gly 29	-	expression tag
Val 30	-	expression tag
His 31	-	expression tag
Ser 32	-	expression tag
Ser 49	Asn 49	conflict
Ser 58	Asn 58	conflict
Gly 74	Asn 74	engineered mutation
Pro 76	Thr 76	engineered mutation
Ser 93	Cys 93	conflict
Asp 116	Asn 116	conflict
Val 132	Ala 132	engineered mutation
Pro 151	-	expression tag
Glu 152	-	expression tag
Ala 153	-	expression tag

B: 1 - 123 (UniProt: Q9BQ51)

PDB	External Database	Details
Asp 37	Asn 37	conflict
Asp 64	Asn 64	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	29378.4
Non-Polymers*	Number of molecules	1
	Total formula weight	24.3
All*	Total formula weight	29402.7

*Water molecules are not included.