6ULV
BRD4-BD1 in complex with the cyclic peptide 4.2_1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Bromodomain-containing protein 4 | polymer | 146 | 17200.6 | 4 | UniProt (O60885) Pfam (PF00439) | Homo sapiens (Human) | Protein HUNK1 |
| 2 | E, F (E, G) | Cyclic peptide 4.2_3 | polymer | 16 | 2095.6 | 2 | synthetic construct | ||
| 3 | G, H, J, K, L... (A, B, C, D, E...) | IODIDE ION | non-polymer | 126.9 | 7 | Chemie (IOD) | |||
| 4 | I (A) | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 282.3 | 1 | Chemie (B3P) | |||
| 5 | N, P (E, G) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | Q, R, S, T, U... (A, B, C, D, E...) | water | water | 18.0 | 240 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 42 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Gln 36 | - | expression tag |
| Gly 37 | - | expression tag |
| Pro 38 | - | expression tag |
| Leu 39 | - | expression tag |
| Gly 40 | - | expression tag |
| Ser 41 | - | expression tag |
| Pro 169 | - | expression tag |
| Glu 170 | - | expression tag |
| Phe 171 | - | expression tag |
| Pro 172 | - | expression tag |
| Gly 173 | - | expression tag |
| Arg 174 | - | expression tag |
| Leu 175 | - | expression tag |
| Glu 176 | - | expression tag |
| Arg 177 | - | expression tag |
| Pro 178 | - | expression tag |
| His 179 | - | expression tag |
| Arg 180 | - | expression tag |
| Asp 181 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 72993.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1354.8 | |
| All* | Total formula weight | 74348.6 |
