6ULG
Cryo-EM structure of the FLCN-FNIP2-Rag-Ragulator complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Folliculin | polymer | 579 | 64551.2 | 1 | UniProt (Q8NFG4) Pfam (PF11704) Pfam (PF16692) | Homo sapiens (Human) | BHD skin lesion fibrofolliculoma protein,Birt-Hogg-Dube syndrome protein |
| 2 | B (A) | Ragulator complex protein LAMTOR3 | polymer | 124 | 13637.7 | 1 | UniProt (Q9UHA4) Pfam (PF08923) | Homo sapiens (Human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3,MEK-binding partner 1,Mp1,Mitogen-activated protein kinase kinase 1-interacting protein 1,Mitogen-activated protein kinase scaffold protein 1 |
| 3 | C (B) | Ragulator complex protein LAMTOR2 | polymer | 125 | 13517.5 | 1 | UniProt (Q9Y2Q5) Pfam (PF03259) | Homo sapiens (Human) | Endosomal adaptor protein p14,Late endosomal/lysosomal Mp1-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2,Mitogen-activated protein-binding protein-interacting protein,MAPBP-interacting protein,Roadblock domain-containing protein 3 |
| 4 | D (C) | Ragulator complex protein LAMTOR5 | polymer | 91 | 9622.9 | 1 | UniProt (O43504) Pfam (PF16672) | Homo sapiens (Human) | Hepatitis B virus X-interacting protein,HBX-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 |
| 5 | E (D) | Ragulator complex protein LAMTOR4 | polymer | 99 | 10753.2 | 1 | UniProt (Q0VGL1) | Homo sapiens (Human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4 |
| 6 | F (E) | Ragulator complex protein LAMTOR1 | polymer | 161 | 17762.8 | 1 | UniProt (Q6IAA8) Pfam (PF15454) | Homo sapiens (Human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1,Lipid raft adaptor protein p18,Protein associated with DRMs and endosomes,p27Kip1-releasing factor from RhoA,p27RF-Rho |
| 7 | G (F) | Ras-related GTP-binding protein A | polymer | 313 | 36628.2 | 1 | UniProt (Q7L523) Pfam (PF04670) | Homo sapiens (Human) | RagA,Adenovirus E3 14.7 kDa-interacting protein 1,FIP-1 |
| 8 | H (G) | Ras-related GTP-binding protein C | polymer | 399 | 44271.8 | 1 | UniProt (Q9HB90) Pfam (PF04670) | Homo sapiens (Human) | RagC,GTPase-interacting protein 2,TIB929 |
| 9 | I (N) | Folliculin-interacting protein 2 | polymer | 1114 | 122260.2 | 1 | UniProt (Q9P278) Pfam (PF14637) Pfam (PF14638) Pfam (PF14636) | Homo sapiens (Human) | FNIP1-like protein,O6-methylguanine-induced apoptosis 1 protein |
| 10 | J (F) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 11 | K (G) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) | |||
| 12 | L (G) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence modifications
F: 1 - 313 (UniProt: Q7L523)
| PDB | External Database | Details |
|---|---|---|
| Asn 21 | Thr 21 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 333005.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 989.7 | |
| All* | Total formula weight | 333995.1 |
