Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6ULG

Cryo-EM structure of the FLCN-FNIP2-Rag-Ragulator complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005765	cellular_component	lysosomal membrane
A	0005770	cellular_component	late endosome
A	0005886	cellular_component	plasma membrane
A	0005925	cellular_component	focal adhesion
A	0008104	biological_process	intracellular protein localization
A	0010008	cellular_component	endosome membrane
A	0019209	molecular_function	kinase activator activity
A	0031902	cellular_component	late endosome membrane
A	0032006	biological_process	regulation of TOR signaling
A	0032008	biological_process	positive regulation of TOR signaling
A	0035579	cellular_component	specific granule membrane
A	0038202	biological_process	TORC1 signaling
A	0060090	molecular_function	molecular adaptor activity
A	0070062	cellular_component	extracellular exosome
A	0070821	cellular_component	tertiary granule membrane
A	0071230	biological_process	cellular response to amino acid stimulus
A	0071986	cellular_component	Ragulator complex
A	1902533	biological_process	positive regulation of intracellular signal transduction
A	1904263	biological_process	positive regulation of TORC1 signaling
A	1990877	cellular_component	FNIP-folliculin RagC/D GAP
B	0001558	biological_process	regulation of cell growth
B	0005085	molecular_function	guanyl-nucleotide exchange factor activity
B	0005737	cellular_component	cytoplasm
B	0005765	cellular_component	lysosomal membrane
B	0005770	cellular_component	late endosome
B	0005886	cellular_component	plasma membrane
B	0008104	biological_process	intracellular protein localization
B	0010008	cellular_component	endosome membrane
B	0031902	cellular_component	late endosome membrane
B	0032008	biological_process	positive regulation of TOR signaling
B	0035579	cellular_component	specific granule membrane
B	0038202	biological_process	TORC1 signaling
B	0060090	molecular_function	molecular adaptor activity
B	0070821	cellular_component	tertiary granule membrane
B	0071230	biological_process	cellular response to amino acid stimulus
B	0071986	cellular_component	Ragulator complex
B	0150116	biological_process	regulation of cell-substrate junction organization
B	1902533	biological_process	positive regulation of intracellular signal transduction
B	1904263	biological_process	positive regulation of TORC1 signaling
B	1990877	cellular_component	FNIP-folliculin RagC/D GAP
C	0005085	molecular_function	guanyl-nucleotide exchange factor activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005765	cellular_component	lysosomal membrane
C	0005829	cellular_component	cytosol
C	0008361	biological_process	regulation of cell size
C	0009615	biological_process	response to virus
C	0010628	biological_process	positive regulation of gene expression
C	0019079	biological_process	viral genome replication
C	0031902	cellular_component	late endosome membrane
C	0032008	biological_process	positive regulation of TOR signaling
C	0032757	biological_process	positive regulation of interleukin-8 production
C	0032991	cellular_component	protein-containing complex
C	0038202	biological_process	TORC1 signaling
C	0043066	biological_process	negative regulation of apoptotic process
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0060090	molecular_function	molecular adaptor activity
C	0061462	biological_process	protein localization to lysosome
C	0071230	biological_process	cellular response to amino acid stimulus
C	0071986	cellular_component	Ragulator complex
C	1900182	biological_process	positive regulation of protein localization to nucleus
C	1904263	biological_process	positive regulation of TORC1 signaling
C	1990877	cellular_component	FNIP-folliculin RagC/D GAP
D	0005085	molecular_function	guanyl-nucleotide exchange factor activity
D	0005515	molecular_function	protein binding
D	0005764	cellular_component	lysosome
D	0005765	cellular_component	lysosomal membrane
D	0008361	biological_process	regulation of cell size
D	0031902	cellular_component	late endosome membrane
D	0032008	biological_process	positive regulation of TOR signaling
D	0038202	biological_process	TORC1 signaling
D	0060090	molecular_function	molecular adaptor activity
D	0061462	biological_process	protein localization to lysosome
D	0071230	biological_process	cellular response to amino acid stimulus
D	0071986	cellular_component	Ragulator complex
D	1904263	biological_process	positive regulation of TORC1 signaling
D	1990877	cellular_component	FNIP-folliculin RagC/D GAP
E	0001558	biological_process	regulation of cell growth
E	0001919	biological_process	regulation of receptor recycling
E	0005085	molecular_function	guanyl-nucleotide exchange factor activity
E	0005515	molecular_function	protein binding
E	0005764	cellular_component	lysosome
E	0005765	cellular_component	lysosomal membrane
E	0005886	cellular_component	plasma membrane
E	0007032	biological_process	endosome organization
E	0007040	biological_process	lysosome organization
E	0008104	biological_process	intracellular protein localization
E	0010874	biological_process	regulation of cholesterol efflux
E	0016197	biological_process	endosomal transport
E	0031669	biological_process	cellular response to nutrient levels
E	0031902	cellular_component	late endosome membrane
E	0032008	biological_process	positive regulation of TOR signaling
E	0032418	biological_process	lysosome localization
E	0035577	cellular_component	azurophil granule membrane
E	0035579	cellular_component	specific granule membrane
E	0038202	biological_process	TORC1 signaling
E	0042632	biological_process	cholesterol homeostasis
E	0043410	biological_process	positive regulation of MAPK cascade
E	0043495	molecular_function	protein-membrane adaptor activity
E	0045121	cellular_component	membrane raft
E	0051020	molecular_function	GTPase binding
E	0060090	molecular_function	molecular adaptor activity
E	0060620	biological_process	regulation of cholesterol import
E	0070062	cellular_component	extracellular exosome
E	0071230	biological_process	cellular response to amino acid stimulus
E	0071986	cellular_component	Ragulator complex
E	0072657	biological_process	protein localization to membrane
E	0101003	cellular_component	ficolin-1-rich granule membrane
E	0150032	biological_process	positive regulation of protein localization to lysosome
E	1904263	biological_process	positive regulation of TORC1 signaling
E	1990877	cellular_component	FNIP-folliculin RagC/D GAP
F	0000166	molecular_function	nucleotide binding
F	0003924	molecular_function	GTPase activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005764	cellular_component	lysosome
F	0005765	cellular_component	lysosomal membrane
F	0005829	cellular_component	cytosol
F	0006915	biological_process	apoptotic process
F	0008104	biological_process	intracellular protein localization
F	0009267	biological_process	cellular response to starvation
F	0010507	biological_process	negative regulation of autophagy
F	0016787	molecular_function	hydrolase activity
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0031669	biological_process	cellular response to nutrient levels
F	0032008	biological_process	positive regulation of TOR signaling
F	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
F	0034198	biological_process	cellular response to amino acid starvation
F	0035556	biological_process	intracellular signal transduction
F	0042593	biological_process	glucose homeostasis
F	0042803	molecular_function	protein homodimerization activity
F	0043495	molecular_function	protein-membrane adaptor activity
F	0046982	molecular_function	protein heterodimerization activity
F	0051219	molecular_function	phosphoprotein binding
F	0061462	biological_process	protein localization to lysosome
F	0071230	biological_process	cellular response to amino acid stimulus
F	0072657	biological_process	protein localization to membrane
F	1904263	biological_process	positive regulation of TORC1 signaling
F	1990130	cellular_component	GATOR1 complex
F	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
F	1990877	cellular_component	FNIP-folliculin RagC/D GAP
G	0000166	molecular_function	nucleotide binding
G	0000287	molecular_function	magnesium ion binding
G	0003924	molecular_function	GTPase activity
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005764	cellular_component	lysosome
G	0005765	cellular_component	lysosomal membrane
G	0005829	cellular_component	cytosol
G	0006351	biological_process	DNA-templated transcription
G	0006915	biological_process	apoptotic process
G	0007264	biological_process	small GTPase-mediated signal transduction
G	0008104	biological_process	intracellular protein localization
G	0008380	biological_process	RNA splicing
G	0009267	biological_process	cellular response to starvation
G	0010507	biological_process	negative regulation of autophagy
G	0016787	molecular_function	hydrolase activity
G	0019003	molecular_function	GDP binding
G	0031669	biological_process	cellular response to nutrient levels
G	0032006	biological_process	regulation of TOR signaling
G	0034198	biological_process	cellular response to amino acid starvation
G	0043200	biological_process	response to amino acid
G	0043495	molecular_function	protein-membrane adaptor activity
G	0046982	molecular_function	protein heterodimerization activity
G	0051020	molecular_function	GTPase binding
G	0060090	molecular_function	molecular adaptor activity
G	0061462	biological_process	protein localization to lysosome
G	0071230	biological_process	cellular response to amino acid stimulus
G	0072657	biological_process	protein localization to membrane
G	0140767	molecular_function	enzyme-substrate adaptor activity
G	1903432	biological_process	regulation of TORC1 signaling
G	1904263	biological_process	positive regulation of TORC1 signaling
G	1990131	cellular_component	Gtr1-Gtr2 GTPase complex
G	1990877	cellular_component	FNIP-folliculin RagC/D GAP
L	0000122	biological_process	negative regulation of transcription by RNA polymerase II
L	0001701	biological_process	in utero embryonic development
L	0004857	molecular_function	enzyme inhibitor activity
L	0005096	molecular_function	GTPase activator activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005764	cellular_component	lysosome
L	0005765	cellular_component	lysosomal membrane
L	0005813	cellular_component	centrosome
L	0005819	cellular_component	spindle
L	0005829	cellular_component	cytosol
L	0005929	cellular_component	cilium
L	0007043	biological_process	cell-cell junction assembly
L	0009267	biological_process	cellular response to starvation
L	0010508	biological_process	positive regulation of autophagy
L	0019899	molecular_function	enzyme binding
L	0030097	biological_process	hemopoiesis
L	0030496	cellular_component	midbody
L	0030511	biological_process	positive regulation of transforming growth factor beta receptor signaling pathway
L	0032006	biological_process	regulation of TOR signaling
L	0032007	biological_process	negative regulation of TOR signaling
L	0032008	biological_process	positive regulation of TOR signaling
L	0032418	biological_process	lysosome localization
L	0034198	biological_process	cellular response to amino acid starvation
L	0035024	biological_process	negative regulation of Rho protein signal transduction
L	0035556	biological_process	intracellular signal transduction
L	0043065	biological_process	positive regulation of apoptotic process
L	0044291	cellular_component	cell-cell contact zone
L	0044877	molecular_function	protein-containing complex binding
L	0045820	biological_process	negative regulation of glycolytic process
L	0045892	biological_process	negative regulation of DNA-templated transcription
L	0046578	biological_process	regulation of Ras protein signal transduction
L	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
L	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
L	0072686	cellular_component	mitotic spindle
L	0097009	biological_process	energy homeostasis
L	0120163	biological_process	negative regulation of cold-induced thermogenesis
L	1901723	biological_process	negative regulation of cell proliferation involved in kidney development
L	1901874	biological_process	negative regulation of post-translational protein modification
L	1902532	biological_process	negative regulation of intracellular signal transduction
L	1903444	biological_process	negative regulation of brown fat cell differentiation
L	1904263	biological_process	positive regulation of TORC1 signaling
L	1905672	biological_process	negative regulation of lysosome organization
L	1990877	cellular_component	FNIP-folliculin RagC/D GAP
L	2000973	biological_process	regulation of pro-B cell differentiation
N	0000122	biological_process	negative regulation of transcription by RNA polymerase II
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0005765	cellular_component	lysosomal membrane
N	0005829	cellular_component	cytosol
N	0006974	biological_process	DNA damage response
N	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
N	0031334	biological_process	positive regulation of protein-containing complex assembly
N	0032007	biological_process	negative regulation of TOR signaling
N	0034451	cellular_component	centriolar satellite
N	0042030	molecular_function	ATPase inhibitor activity
N	0051087	molecular_function	protein-folding chaperone binding
N	1904263	biological_process	positive regulation of TORC1 signaling
N	1990877	cellular_component	FNIP-folliculin RagC/D GAP

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue GDP F 500

Chain	Residue
F	SER16
F	SER163
F	ILE164
N	ALA147
N	MET148
F	GLY17
F	SER18
F	GLY19
F	LYS20
F	ASN21
F	SER22
F	HIS127
F	ASP130

site_id	AC2
Number of Residues	18
Details	binding site for residue GNP G 401

Chain	Residue
G	ARG70
G	ARG71
G	GLY73
G	LYS74
G	SER75
G	SER76
G	LEU91
G	SER95
G	THR96
G	PHE117
G	GLY119
G	HIS178
G	LYS179
G	ASP181
G	SER219
G	ILE220
G	TYR221
G	MG402

site_id	AC3
Number of Residues	3
Details	binding site for residue MG G 402

Chain	Residue
G	SER75
G	THR96
G	GNP401

Functional Information from PROSITE/UniProt

site_id	PS00214
Number of Residues	18
Details	FABP Cytosolic fatty-acid binding proteins signature. KAYkVnpDmNFEvFIHKV

Chain	Residue	Details
G	LYS163-VAL180

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	156
Details	Domain: {"description":"uDENN FLCN/SMCR8-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01178","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	65
Details	Domain: {"description":"dDENN FLCN/SMCR8-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01178","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	10
Details	Region: {"description":"Essential for interaction with LDHA","evidences":[{"source":"PubMed","id":"34381247","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Essential for GTPase activation (GAP) activity","evidences":[{"source":"PubMed","id":"31672913","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31704029","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine; by ULK1","evidences":[{"source":"PubMed","id":"25126726","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	13
Details	Region: {"description":"Required for interaction with LAMTOR2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	13
Details	Region: {"description":"Required for location at endosomes","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"31314152","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	1
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36476874","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q9CQ22","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36103527","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DHB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31672913","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31704029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ULG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31704029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6ULG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	5
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"25936802","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q99K70","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	55
Details	Domain: {"description":"dDENN FNIP1/2-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01180","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)