6ULD

Crystal structure of serine hydroxymethyltransferase from Mycobacterium tuberculosis with bound PLP forming a Schiff base with substrate Serine in one monomer and PLP forming a Schiff base with product Glycine in the other monomer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Serine hydroxymethyltransferase	polymer	447	47372.8	2	UniProt (A0A0T9NP28)	Mycobacterium tuberculosis	Serine methylase, MytuD.00783.a
2	C, F (A, B)	PYRIDOXAL-5'-PHOSPHATE	non-polymer		247.1	2	Chemie (PLP)
3	D (A)	GLYCINE	non-polymer		75.1	1	Chemie (GLY)
4	E (A)	SERINE	non-polymer		105.1	1	Chemie (SER)
5	G, H (B)	(4S)-2-METHYL-2,4-PENTANEDIOL	non-polymer		118.2	2	Chemie (MPD)
6	I, J (A, B)	water	water		18.0	594	Chemie (HOH)

Sequence modifications

A, B: 22 - 447 (UniProt: A0A0T9NP28)

PDB	External Database	Details
Met 1	-	initiating methionine
Ala 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
Met 9	-	expression tag
Gly 10	-	expression tag
Thr 11	-	expression tag
Leu 12	-	expression tag
Glu 13	-	expression tag
Ala 14	-	expression tag
Gln 15	-	expression tag
Thr 16	-	expression tag
Gln 17	-	expression tag
Gly 18	-	expression tag
Pro 19	-	expression tag
Gly 20	-	expression tag
Ser 21	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	94745.5
Non-Polymers*	Number of molecules	6
	Total formula weight	910.8
All*	Total formula weight	95656.3

*Water molecules are not included.