6ULD
Crystal structure of serine hydroxymethyltransferase from Mycobacterium tuberculosis with bound PLP forming a Schiff base with substrate Serine in one monomer and PLP forming a Schiff base with product Glycine in the other monomer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| A | 0019264 | biological_process | glycine biosynthetic process from serine |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| B | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| B | 0019264 | biological_process | glycine biosynthetic process from serine |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0035999 | biological_process | tetrahydrofolate interconversion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue SER A 503 |
| Chain | Residue |
| A | TYR73 |
| B | ARG384 |
| B | PLP501 |
| A | GLU75 |
| A | TYR83 |
| A | HOH601 |
| B | SER53 |
| B | HIS144 |
| B | SER194 |
| B | HIS222 |
| B | LYS248 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MPD B 502 |
| Chain | Residue |
| B | GLY131 |
| B | LYS156 |
| B | LEU157 |
| B | TYR158 |
| B | GLU159 |
| B | HOH707 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue MPD B 503 |
| Chain | Residue |
| B | LEU77 |
| B | ARG80 |
| B | TYR82 |
| B | ASN269 |
| B | SER270 |
| B | PHE273 |
| B | PRO274 |
| B | SER416 |
| B | HOH650 |
| B | HOH674 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | binding site for Ligand PLP B 501 bound to SER A 503 |
| Chain | Residue |
| A | TYR73 |
| A | GLY278 |
| A | GLY279 |
| A | SER503 |
| A | HOH612 |
| B | SER115 |
| B | GLY116 |
| B | ALA117 |
| B | HIS144 |
| B | TRP193 |
| B | SER194 |
| B | ASP219 |
| B | ALA221 |
| B | HIS222 |
| B | THR245 |
| B | HIS247 |
| B | LYS248 |
| B | HOH715 |
| B | HOH751 |
| site_id | AC5 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide PLP A 501 and GLY A 502 |
| Chain | Residue |
| A | SER53 |
| A | SER115 |
| A | GLY116 |
| A | ALA117 |
| A | HIS144 |
| A | TRP193 |
| A | SER194 |
| A | ASP219 |
| A | ALA221 |
| A | HIS222 |
| A | THR245 |
| A | HIS247 |
| A | LYS248 |
| A | ARG384 |
| A | HOH633 |
| A | HOH771 |
| B | TYR73 |
| B | TYR83 |
| B | GLY278 |
| B | GLY279 |
Functional Information from PROSITE/UniProt
| site_id | PS00096 |
| Number of Residues | 17 |
| Details | SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. DVvSTTVHKTLgGGRSG |
| Chain | Residue | Details |
| A | ASP240-GLY256 |
