6UK3

Crystal Structure of S-adenosyl-L-homocysteine hydrolase from Acanthamoeba castellanii with bound NAD and Adenosine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Adenosylhomocysteinase	polymer	485	54174.9	4	UniProt (L8H6B5) Pfam (PF05221) Pfam (PF00670)	Acanthamoeba castellanii str. Neff
2	E, J, R, X (A, B, C, D)	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	4	Chemie (NAD)
3	F, K, S, Y (A, B, C, D)	ADENOSINE	non-polymer		267.2	4	Chemie (ADN)
4	BA, CA, G, N, O... (D, A, B, C)	FORMIC ACID	non-polymer		46.0	9	Chemie (FMT)
5	EA, H, P, W (D, A, B, C)	POTASSIUM ION	non-polymer		39.1	4	Chemie (K)
6	I (A)	OXAMIC ACID	non-polymer		89.0	1	Chemie (OXM)
7	AA, DA, L, M, U (D, B, C)	ACETATE ION	non-polymer		59.0	5	Chemie (ACT)
8	FA, GA, HA, IA (A, B, C, D)	water	water		18.0	2329	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 477 (UniProt: L8H6B5)

PDB	External Database	Details
Met -7	-	initiating methionine
Ala -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	216699.7
Non-Polymers*	Number of molecules	27
	Total formula weight	4677.6
All*	Total formula weight	221377.3

*Water molecules are not included.