6UK0

HIV-1 M184V reverse transcriptase-DNA complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	p66 Reverse transcriptase/RNaseH	polymer	572	65855.3	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB	Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)	Pr160Gag-Pol
2	B	p51 Reverse transcriptase/RNaseH	polymer	440	51350.9	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB	Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)	Pr160Gag-Pol
3	P	Primer DNA	polymer	21	6360.1	1		Human immunodeficiency virus 1
4	T	Template DNA	polymer	27	8448.4	1		Human immunodeficiency virus 1
5	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6	A, P, T	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
7		water	water		18.0	21	Chemie (HOH)

Sequence modifications

A: 1 - 560 (UniProt: P04585)

PDB	External Database	Details
Met -11	-	initiating methionine
Gly -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Ser -1	-	expression tag
Ser 0	-	expression tag
Val 184	Met 771	engineered mutation
Cys 258	Gln 845	engineered mutation
Ser 280	Cys 867	engineered mutation

B: 1 - 440 (UniProt: P04585)

PDB	External Database	Details
Val 184	Met 771	engineered mutation
Ser 280	Cys 867	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	132014.7
Non-Polymers*	Number of molecules	4
	Total formula weight	312.5
All*	Total formula weight	132327.2

*Water molecules are not included.