6UJY
HIV-1 wild-type reverse transcriptase-DNA complex with (-)-3TC-TP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | p66 Reverse transcriptase/RNaseH | polymer | 572 | 65887.3 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) | Exoribonuclease H, p66 RT |
2 | B | p51 Reverse transcriptase/RNaseH | polymer | 440 | 51383.0 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) | Exoribonuclease H, p51 RT |
3 | P | primer DNA | polymer | 21 | 6360.1 | 1 | Human immunodeficiency virus 1 | ||
4 | T | template DNA | polymer | 27 | 8448.4 | 1 | Human immunodeficiency virus 1 | ||
5 | A | Lamivudine Triphosphate | non-polymer | 469.2 | 1 | Chemie (1RZ) | |||
6 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
7 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
8 | water | water | 18.0 | 189 | Chemie (HOH) |
Sequence modifications
A: 1 - 560 (UniProt: P04585)
B: 1 - 440 (UniProt: P04585)
PDB | External Database | Details |
---|---|---|
Met -11 | - | initiating methionine |
Gly -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Cys 258 | Gln 845 | engineered mutation |
Ser 280 | Cys 867 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ser 280 | Cys 867 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 132078.8 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 685.6 | |
All* | Total formula weight | 132764.5 |