6UIT

HIV-1 wild-type reverse transcriptase-DNA complex with dCTP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	p66 Reverse transcriptase/RNaseH	polymer	572	65887.3	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075)	Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)	Exoribonuclease H, p66 RT
2	B (B)	p51 Reverse transcriptase/RNaseH	polymer	440	51383.0	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815)	Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)
3	C (P)	DNA primer	polymer	21	6360.1	1		Human immunodeficiency virus 1
4	D (T)	DNA template	polymer	27	8448.4	1		Human immunodeficiency virus 1
5	E (A)	2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE	non-polymer		467.2	1	Chemie (DCP)
6	F, G, I (A, P)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
7	H (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
8	J, K, L (A, B, T)	water	water		18.0	34	Chemie (HOH)

Sequence modifications

A: 1 - 560 (UniProt: P04585)

PDB	External Database	Details
Met -11	-	initiating methionine
Gly -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Ser -1	-	expression tag
Ser 0	-	expression tag
Cys 258	Gln 845	engineered mutation
Ser 280	Cys 867	engineered mutation

B: 1 - 440 (UniProt: P04585)

PDB	External Database	Details
Ser 280	Cys 867	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	132078.8
Non-Polymers*	Number of molecules	5
	Total formula weight	779.7
All*	Total formula weight	132858.5

*Water molecules are not included.