6UHC
CryoEM structure of human Arp2/3 complex with bound NPFs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Actin-related protein 3 | polymer | 418 | 47428.0 | 1 | UniProt (P61158) Pfam (PF00022) | Homo sapiens (Human) | Actin-like protein 3 |
| 2 | B (B) | Actin-related protein 2 | polymer | 394 | 44818.7 | 1 | UniProt (P61160) Pfam (PF00022) | Homo sapiens (Human) | Actin-like protein 2 |
| 3 | C (C) | Actin-related protein 2/3 complex subunit 1B | polymer | 372 | 41004.8 | 1 | UniProt (O15143) Pfam (PF00400) | Homo sapiens (Human) | Arp2/3 complex 41 kDa subunit,p41-ARC |
| 4 | D (D) | Actin-related protein 2/3 complex subunit 2 | polymer | 300 | 34386.0 | 1 | UniProt (O15144) Pfam (PF04045) | Homo sapiens (Human) | Arp2/3 complex 34 kDa subunit,p34-ARC |
| 5 | E (E) | Actin-related protein 2/3 complex subunit 3 | polymer | 203 | 23196.3 | 1 | UniProt (O15145) Pfam (PF04062) | Homo sapiens (Human) | Arp2/3 complex 21 kDa subunit,p21-ARC |
| 6 | F (F) | Actin-related protein 2/3 complex subunit 4 | polymer | 168 | 19697.0 | 1 | UniProt (P59998) Pfam (PF05856) | Homo sapiens (Human) | Arp2/3 complex 20 kDa subunit,p20-ARC |
| 7 | G (G) | Actin-related protein 2/3 complex subunit 5 | polymer | 151 | 16341.4 | 1 | UniProt (O15511) Pfam (PF04699) | Homo sapiens (Human) | Arp2/3 complex 16 kDa subunit,p16-ARC |
| 8 | H, I (H, I) | Neural Wiskott-Aldrich syndrome protein | polymer | 501 | 54342.0 | 2 | UniProt (Q91YD9) Pfam (PF00568) Pfam (PF00786) Pfam (PF02205) | Mus musculus (Mouse) | N-WASP |
| 9 | J, L (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 10 | K, M (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) |
Sequence modifications
E: 1 - 178 (UniProt: O15145)
| PDB | External Database | Details |
|---|---|---|
| Gly 179 | - | expression tag |
| Thr 180 | - | expression tag |
| Ser 181 | - | expression tag |
| Glu 182 | - | expression tag |
| Asn 183 | - | expression tag |
| Leu 184 | - | expression tag |
| Tyr 185 | - | expression tag |
| Gln 186 | - | expression tag |
| Gly 187 | - | expression tag |
| Gly 188 | - | expression tag |
| Gly 189 | - | expression tag |
| Asp 190 | - | expression tag |
| Tyr 191 | - | expression tag |
| Lys 192 | - | expression tag |
| Asp 193 | - | expression tag |
| Asp 194 | - | expression tag |
| Asp 195 | - | expression tag |
| Asp 196 | - | expression tag |
| Lys 197 | - | expression tag |
| Cys 198 | - | expression tag |
| Gly 199 | - | expression tag |
| Arg 200 | - | expression tag |
| Ala 201 | - | expression tag |
| Ser 202 | - | expression tag |
| Ser 203 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 335556.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1063.0 | |
| All* | Total formula weight | 336619.4 |
