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6UHC

CryoEM structure of human Arp2/3 complex with bound NPFs

Functional Information from GO Data
ChainGOidnamespacecontents
A0003779molecular_functionactin binding
A0005200molecular_functionstructural constituent of cytoskeleton
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005885cellular_componentArp2/3 protein complex
A0005903cellular_componentbrush border
A0005911cellular_componentcell-cell junction
A0005925cellular_componentfocal adhesion
A0007163biological_processestablishment or maintenance of cell polarity
A0008356biological_processasymmetric cell division
A0010592biological_processpositive regulation of lamellipodium assembly
A0015629cellular_componentactin cytoskeleton
A0016020cellular_componentmembrane
A0016344biological_processmeiotic chromosome movement towards spindle pole
A0030027cellular_componentlamellipodium
A0030030biological_processcell projection organization
A0033206biological_processmeiotic cytokinesis
A0034314biological_processArp2/3 complex-mediated actin nucleation
A0035861cellular_componentsite of double-strand break
A0042995cellular_componentcell projection
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0051015molecular_functionactin filament binding
A0051321biological_processmeiotic cell cycle
A0051653biological_processspindle localization
A0060271biological_processcilium assembly
A0070062cellular_componentextracellular exosome
A0070358biological_processactin polymerization-dependent cell motility
A0071346biological_processcellular response to type II interferon
B0003779molecular_functionactin binding
B0005200molecular_functionstructural constituent of cytoskeleton
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005885cellular_componentArp2/3 protein complex
B0005925cellular_componentfocal adhesion
B0005938cellular_componentcell cortex
B0007163biological_processestablishment or maintenance of cell polarity
B0008356biological_processasymmetric cell division
B0010592biological_processpositive regulation of lamellipodium assembly
B0015629cellular_componentactin cytoskeleton
B0016020cellular_componentmembrane
B0016344biological_processmeiotic chromosome movement towards spindle pole
B0016482biological_processcytosolic transport
B0030036biological_processactin cytoskeleton organization
B0030478cellular_componentactin cap
B0033206biological_processmeiotic cytokinesis
B0034314biological_processArp2/3 complex-mediated actin nucleation
B0035578cellular_componentazurophil granule lumen
B0035861cellular_componentsite of double-strand break
B0042995cellular_componentcell projection
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0051015molecular_functionactin filament binding
B0051321biological_processmeiotic cell cycle
B0051653biological_processspindle localization
B0060271biological_processcilium assembly
B0070062cellular_componentextracellular exosome
B0071346biological_processcellular response to type II interferon
B1904813cellular_componentficolin-1-rich granule lumen
B1905168biological_processpositive regulation of double-strand break repair via homologous recombination
B2001032biological_processregulation of double-strand break repair via nonhomologous end joining
C0003779molecular_functionactin binding
C0005200molecular_functionstructural constituent of cytoskeleton
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005885cellular_componentArp2/3 protein complex
C0005925cellular_componentfocal adhesion
C0015629cellular_componentactin cytoskeleton
C0032355biological_processresponse to estradiol
C0034314biological_processArp2/3 complex-mediated actin nucleation
C0036284cellular_componenttubulobulbar complex
C0043627biological_processresponse to estrogen
C0044877molecular_functionprotein-containing complex binding
C0051015molecular_functionactin filament binding
C0070062cellular_componentextracellular exosome
D0003779molecular_functionactin binding
D0005200molecular_functionstructural constituent of cytoskeleton
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005768cellular_componentendosome
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005885cellular_componentArp2/3 protein complex
D0005886cellular_componentplasma membrane
D0005925cellular_componentfocal adhesion
D0010592biological_processpositive regulation of lamellipodium assembly
D0015629cellular_componentactin cytoskeleton
D0030027cellular_componentlamellipodium
D0030041biological_processactin filament polymerization
D0030838biological_processpositive regulation of actin filament polymerization
D0031252cellular_componentcell leading edge
D0034314biological_processArp2/3 complex-mediated actin nucleation
D0035861cellular_componentsite of double-strand break
D0036195cellular_componentmuscle cell projection membrane
D0042995cellular_componentcell projection
D0043005cellular_componentneuron projection
D0045202cellular_componentsynapse
D0051015molecular_functionactin filament binding
D0070062cellular_componentextracellular exosome
D0070358biological_processactin polymerization-dependent cell motility
D0098978cellular_componentglutamatergic synapse
D1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
E0003779molecular_functionactin binding
E0005200molecular_functionstructural constituent of cytoskeleton
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0005885cellular_componentArp2/3 protein complex
E0005925cellular_componentfocal adhesion
E0015629cellular_componentactin cytoskeleton
E0016020cellular_componentmembrane
E0030027cellular_componentlamellipodium
E0030833biological_processregulation of actin filament polymerization
E0031252cellular_componentcell leading edge
E0031941cellular_componentfilamentous actin
E0034314biological_processArp2/3 complex-mediated actin nucleation
E0035861cellular_componentsite of double-strand break
E0042995cellular_componentcell projection
E0051015molecular_functionactin filament binding
E0061850cellular_componentgrowth cone leading edge
E0070062cellular_componentextracellular exosome
E0070358biological_processactin polymerization-dependent cell motility
E1990090biological_processcellular response to nerve growth factor stimulus
F0003779molecular_functionactin binding
F0005200molecular_functionstructural constituent of cytoskeleton
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005885cellular_componentArp2/3 protein complex
F0015629cellular_componentactin cytoskeleton
F0019899molecular_functionenzyme binding
F0030041biological_processactin filament polymerization
F0030674molecular_functionprotein-macromolecule adaptor activity
F0034314biological_processArp2/3 complex-mediated actin nucleation
F0035861cellular_componentsite of double-strand break
F0042995cellular_componentcell projection
F0045010biological_processactin nucleation
F0051015molecular_functionactin filament binding
F0070062cellular_componentextracellular exosome
G0003779molecular_functionactin binding
G0005200molecular_functionstructural constituent of cytoskeleton
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005856cellular_componentcytoskeleton
G0005885cellular_componentArp2/3 protein complex
G0005925cellular_componentfocal adhesion
G0015629cellular_componentactin cytoskeleton
G0016477biological_processcell migration
G0030027cellular_componentlamellipodium
G0030036biological_processactin cytoskeleton organization
G0030833biological_processregulation of actin filament polymerization
G0034314biological_processArp2/3 complex-mediated actin nucleation
G0034774cellular_componentsecretory granule lumen
G0035861cellular_componentsite of double-strand break
G0042995cellular_componentcell projection
G0051015molecular_functionactin filament binding
G0070062cellular_componentextracellular exosome
G1904813cellular_componentficolin-1-rich granule lumen
H0000139cellular_componentGolgi membrane
H0003779molecular_functionactin binding
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005856cellular_componentcytoskeleton
H0006900biological_processvesicle budding from membrane
H0007015biological_processactin filament organization
H0008092molecular_functioncytoskeletal protein binding
H0009617biological_processresponse to bacterium
H0010324biological_processmembrane invagination
H0016050biological_processvesicle organization
H0030027cellular_componentlamellipodium
H0030031biological_processcell projection assembly
H0030036biological_processactin cytoskeleton organization
H0030041biological_processactin filament polymerization
H0030050biological_processvesicle transport along actin filament
H0030478cellular_componentactin cap
H0031252cellular_componentcell leading edge
H0031410cellular_componentcytoplasmic vesicle
H0031503biological_processprotein-containing complex localization
H0032880biological_processregulation of protein localization
H0042802molecular_functionidentical protein binding
H0045010biological_processactin nucleation
H0045944biological_processpositive regulation of transcription by RNA polymerase II
H0050921biological_processpositive regulation of chemotaxis
H0051301biological_processcell division
H0051491biological_processpositive regulation of filopodium assembly
H0051653biological_processspindle localization
H0060491biological_processregulation of cell projection assembly
H0060997biological_processdendritic spine morphogenesis
H0097320biological_processplasma membrane tubulation
H0098794cellular_componentpostsynapse
H0098974biological_processpostsynaptic actin cytoskeleton organization
H0098978cellular_componentglutamatergic synapse
H0099173biological_processpostsynapse organization
H0099175biological_processregulation of postsynapse organization
H1903526biological_processnegative regulation of membrane tubulation
H2000370biological_processpositive regulation of clathrin-dependent endocytosis
H2000402biological_processnegative regulation of lymphocyte migration
I0000139cellular_componentGolgi membrane
I0003779molecular_functionactin binding
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0005856cellular_componentcytoskeleton
I0006900biological_processvesicle budding from membrane
I0007015biological_processactin filament organization
I0008092molecular_functioncytoskeletal protein binding
I0009617biological_processresponse to bacterium
I0010324biological_processmembrane invagination
I0016050biological_processvesicle organization
I0030027cellular_componentlamellipodium
I0030031biological_processcell projection assembly
I0030036biological_processactin cytoskeleton organization
I0030041biological_processactin filament polymerization
I0030050biological_processvesicle transport along actin filament
I0030478cellular_componentactin cap
I0031252cellular_componentcell leading edge
I0031410cellular_componentcytoplasmic vesicle
I0031503biological_processprotein-containing complex localization
I0032880biological_processregulation of protein localization
I0042802molecular_functionidentical protein binding
I0045010biological_processactin nucleation
I0045944biological_processpositive regulation of transcription by RNA polymerase II
I0050921biological_processpositive regulation of chemotaxis
I0051301biological_processcell division
I0051491biological_processpositive regulation of filopodium assembly
I0051653biological_processspindle localization
I0060491biological_processregulation of cell projection assembly
I0060997biological_processdendritic spine morphogenesis
I0097320biological_processplasma membrane tubulation
I0098794cellular_componentpostsynapse
I0098974biological_processpostsynaptic actin cytoskeleton organization
I0098978cellular_componentglutamatergic synapse
I0099173biological_processpostsynapse organization
I0099175biological_processregulation of postsynapse organization
I1903526biological_processnegative regulation of membrane tubulation
I2000370biological_processpositive regulation of clathrin-dependent endocytosis
I2000402biological_processnegative regulation of lymphocyte migration
Functional Information from PDB Data
site_idAC1
Number of Residues3
Detailsbinding site for residue MG A 501
ChainResidue
AASP11
AGLN144
AATP502

site_idAC2
Number of Residues14
Detailsbinding site for residue ATP A 502
ChainResidue
AASP172
AVAL174
AGLY197
ALYS228
AGLU229
AGLY324
APHE328
AMG501
AGLY13
ATHR14
AGLY15
ATYR16
AASP169
AGLY171

site_idAC3
Number of Residues2
Detailsbinding site for residue MG B 501
ChainResidue
BGLN141
BATP502

site_idAC4
Number of Residues9
Detailsbinding site for residue ATP B 502
ChainResidue
BTHR15
BGLY16
BASP161
BGLY186
BARG214
BLYS217
BGLU218
BGLY306
BMG501

Functional Information from PROSITE/UniProt
site_idPS01132
Number of Residues13
DetailsACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEPpMNPtkNR
ChainResidueDetails
BLEU108-ARG120
ALEU111-ARG123

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N-acetylserine => ECO:0000250|UniProtKB:O00401
ChainResidueDetails
HSER2
ISER2
BGLY305

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine; by TNK2 => ECO:0000250|UniProtKB:O00401
ChainResidueDetails
HSER239
ISER239
ALYS251
ALYS254

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by FAK1 and TNK2 => ECO:0000269|PubMed:14676198, ECO:0007744|PubMed:18034455, ECO:0007744|PubMed:19131326, ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079
ChainResidueDetails
HTYR253
ITYR253

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:O00401
ChainResidueDetails
HARG304
IARG304

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079
ChainResidueDetails
HSER480
ISER480

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O00401
ChainResidueDetails
HSER481
ISER481

223166

PDB entries from 2024-07-31

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