6UGV

Crystal structure of the Fab fragment of anti-TNFa antibody infliximab (Remicade) in a I-centered orthorhombic crystal form, Lot C

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (H, A)	Infliximab Fab Heavy Chain	polymer	226	24356.2	2	UniProt (A8K008) Pfam (PF07686) Pfam (PF07654)	Homo sapiens (Human)
2	B, D (L, B)	Infliximab Fab Light Chain	polymer	214	23460.9	2	UniProt (Q6P5S8) Pfam (PF07686) Pfam (PF07654)	Homo sapiens (Human)
3	E, G (H, A)	MESO-ERYTHRITOL	non-polymer		122.1	2	Chemie (MRY)
4	F, H, I (H, A, B)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
5	J, K, L, M (H, L, A, B)	water	water		18.0	615	Chemie (HOH)

Sequence modifications

H, A: 1 - 116 (PDB: 6UGV)
H, A: 117 - 226 (UniProt: A8K008)
L, B: 1 - 106 (PDB: 6UGV)
L, B: 107 - 214 (UniProt: Q6P5S8)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	95634.1
Non-Polymers*	Number of molecules	5
	Total formula weight	430.4
All*	Total formula weight	96064.5

*Water molecules are not included.