6UGV

Crystal structure of the Fab fragment of anti-TNFa antibody infliximab (Remicade) in a I-centered orthorhombic crystal form, Lot C

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0002250	biological_process	adaptive immune response
B	0002376	biological_process	immune system process
B	0005576	cellular_component	extracellular region
B	0005886	cellular_component	plasma membrane
B	0016020	cellular_component	membrane
B	0019814	cellular_component	immunoglobulin complex
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0005576	cellular_component	extracellular region
L	0005886	cellular_component	plasma membrane
L	0016020	cellular_component	membrane
L	0019814	cellular_component	immunoglobulin complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MRY H 301

Chain	Residue
H	GLY141
H	GLY141
H	THR142
H	THR142
H	THR190
H	PRO192

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site_id	AC2
Number of Residues	7
Details	binding site for residue EDO H 302

Chain	Residue
H	GLY104
H	SER105
H	HOH409
L	TYR50
H	ASN31
H	TYR103
H	TYR103

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site_id	AC3
Number of Residues	2
Details	binding site for residue MRY A 301

Chain	Residue
A	THR142
A	THR142

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site_id	AC4
Number of Residues	6
Details	binding site for residue EDO A 302

Chain	Residue
A	ASN31
A	TYR103
A	TYR103
A	HOH415
A	HOH439
B	TYR50

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site_id	AC5
Number of Residues	3
Details	binding site for residue EDO B 301

Chain	Residue
B	GLN38
B	ASN41
B	GLY42

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR192-HIS198
H	TYR201-HIS207

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