6UDJ

HIV-1 bNAb 1-18 in complex with BG505 SOSIP.664 and 10-1074

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, K, Q	10-1074 Fab Heavy Chain	polymer	238	25661.7	3	UniProt (S6B2B6) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
2	E, O, I	1-18 Fab Light Chain	polymer	234	25330.4	3	UniProt (Q6PIL8) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
3	B, L, R	10-1074 Fab Light Chain	polymer	214	23180.8	3	UniProt (Q8N355) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
4	D, N, H	1-18 Fab Heavy Chain	polymer	480	53133.8	3		Homo sapiens (Human)
5	C, M, F	Envelope glycoprotein gp41	polymer	153	17146.5	3	UniProt (Q2N0S6) Pfam (PF00517) In PDB	Human immunodeficiency virus 1 (HIV-1)	BG505 SOSIP gp41
6	G, J, P	Envelope glycoprotein gp120	polymer	479	53864.1	3	UniProt (Q2N0S6) Pfam (PF00516) In PDB	Human immunodeficiency virus 1 (HIV-1)	BG505 SOSIP gp120
7	S, T, U	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1559.4	3	In PDB GlyTouCan (G68668TB)
8	a, 0, c, 2, 4...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	18	In PDB GlyTouCan (G42666HT)
9	i, AA, l, w, X...	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	6	In PDB GlyTouCan (G22768VO)
10	1, d, 5, n, r...	alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	6	In PDB GlyTouCan (G22573RC)
11	b, 3, p	alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1073.0	3	In PDB GlyTouCan (G09724ZC)
12	e, g, 6, h, 8...	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	9	In PDB GlyTouCan (G15407YE)
13	C, G, M, J, F...	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	15	Chemie (NAG)
14		water	water		18.0	45	Chemie (HOH)

Sequence modifications

A, K, Q: 1 - 108 (PDB: 6UDJ)
A, K, Q: 109 - 219 (UniProt: S6B2B6)
E, O, I: -18 - 106 (PDB: 6UDJ)
E, O, I: 107 - 214 (UniProt: Q6PIL8)
B, L, R: 6 - 103 (PDB: 6UDJ)
B, L, R: 104 - 213 (UniProt: Q8N355)
C, M, F: 512 - 664 (UniProt: Q2N0S6)

PDB	External Database	Details
Pro 559	Ile 556	conflict
Cys 605	Thr 602	conflict

G, J, P: 33 - 508 (UniProt: Q2N0S6)

PDB	External Database	Details
Asn 332	Thr 330	conflict
Cys 501	Ala 498	conflict
Arg 509	-	expression tag
Arg 510	-	expression tag
Arg 511	-	expression tag
Arg 512	-	expression tag
Arg 513	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	18
	Total formula weight	594951.6
Branched	Number of molecules	45
	Total formula weight	30772.2
Non-Polymers*	Number of molecules	15
	Total formula weight	3318.1
All*	Total formula weight	629041.9

*Water molecules are not included.