6UAP
Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD6309 bound
Replaces: 6DU1Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C, E, G | Tryptophan synthase alpha chain | polymer | 276 | 28579.4 | 4 | UniProt (P9WFY1) Pfam (PF00290) In PDB | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | |
2 | B, D, F, H | Tryptophan synthase beta chain | polymer | 410 | 43562.7 | 4 | UniProt (P9WFX9) Pfam (PF00291) In PDB | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | |
3 | D, A, F, B, G... | FORMIC ACID | non-polymer | 46.0 | 23 | Chemie (FMT) | |||
4 | D, A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
5 | F, B, H, D | (2R,3S,4R)-3-(4'-chloro-2',6'-difluoro[1,1'-biphenyl]-4-yl)-4-(fluoromethyl)azetidine-2-carbonitrile | non-polymer | 336.7 | 4 | Chemie (H9V) | |||
6 | B, F, C | MALONIC ACID | non-polymer | 104.1 | 3 | Chemie (MLA) | |||
7 | D, B, F, H | D-MALATE | non-polymer | 134.1 | 5 | Chemie (MLT) | |||
8 | D, G, H | ACETATE ION | non-polymer | 59.0 | 6 | Chemie (ACT) | |||
9 | water | water | 18.0 | 302 | Chemie (HOH) |
Sequence modifications
A, C, E, G: 1 - 270 (UniProt: P9WFY1)
PDB | External Database | Details |
---|---|---|
His 271 | - | expression tag |
His 272 | - | expression tag |
His 273 | - | expression tag |
His 274 | - | expression tag |
His 275 | - | expression tag |
His 276 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 288568.6 | |
Non-Polymers* | Number of molecules | 43 |
Total formula weight | 3866.5 | |
All* | Total formula weight | 292435.2 |