6UAP
Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD6309 bound
Replaces: 6DU1Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000162 | biological_process | L-tryptophan biosynthetic process |
| A | 0004834 | molecular_function | tryptophan synthase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006568 | biological_process | L-tryptophan metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| B | 0000162 | biological_process | L-tryptophan biosynthetic process |
| B | 0004834 | molecular_function | tryptophan synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006568 | biological_process | L-tryptophan metabolic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 1901605 | biological_process | alpha-amino acid metabolic process |
| C | 0000162 | biological_process | L-tryptophan biosynthetic process |
| C | 0004834 | molecular_function | tryptophan synthase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006568 | biological_process | L-tryptophan metabolic process |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| D | 0000162 | biological_process | L-tryptophan biosynthetic process |
| D | 0004834 | molecular_function | tryptophan synthase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006568 | biological_process | L-tryptophan metabolic process |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 1901605 | biological_process | alpha-amino acid metabolic process |
| E | 0000162 | biological_process | L-tryptophan biosynthetic process |
| E | 0004834 | molecular_function | tryptophan synthase activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0006568 | biological_process | L-tryptophan metabolic process |
| E | 0008652 | biological_process | amino acid biosynthetic process |
| E | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| E | 0016829 | molecular_function | lyase activity |
| F | 0000162 | biological_process | L-tryptophan biosynthetic process |
| F | 0004834 | molecular_function | tryptophan synthase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006568 | biological_process | L-tryptophan metabolic process |
| F | 0008652 | biological_process | amino acid biosynthetic process |
| F | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| F | 0016829 | molecular_function | lyase activity |
| F | 1901605 | biological_process | alpha-amino acid metabolic process |
| G | 0000162 | biological_process | L-tryptophan biosynthetic process |
| G | 0004834 | molecular_function | tryptophan synthase activity |
| G | 0005829 | cellular_component | cytosol |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0006568 | biological_process | L-tryptophan metabolic process |
| G | 0008652 | biological_process | amino acid biosynthetic process |
| G | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| G | 0016829 | molecular_function | lyase activity |
| H | 0000162 | biological_process | L-tryptophan biosynthetic process |
| H | 0004834 | molecular_function | tryptophan synthase activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0006568 | biological_process | L-tryptophan metabolic process |
| H | 0008652 | biological_process | amino acid biosynthetic process |
| H | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| H | 0016829 | molecular_function | lyase activity |
| H | 1901605 | biological_process | alpha-amino acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue FMT A 501 |
| Chain | Residue |
| A | MET67 |
| A | MET106 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue FMT A 502 |
| Chain | Residue |
| A | TYR30 |
| A | VAL60 |
| A | ASP68 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | TYR181 |
| A | GLY217 |
| A | GLY239 |
| A | SER240 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | binding site for residue H9V B 501 |
| Chain | Residue |
| A | ASP64 |
| A | GLY66 |
| A | ASP136 |
| B | VAL30 |
| B | PRO31 |
| B | LEU34 |
| B | ILE184 |
| B | ASN185 |
| B | PHE188 |
| B | PHE202 |
| B | PRO208 |
| B | PHE211 |
| B | HIS294 |
| B | HOH624 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue FMT B 502 |
| Chain | Residue |
| B | SER23 |
| B | TYR29 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue FMT B 503 |
| Chain | Residue |
| B | ARG236 |
| B | LEU237 |
| B | PRO238 |
| B | GLY263 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue MLA B 504 |
| Chain | Residue |
| B | ASP274 |
| B | THR342 |
| B | SER344 |
| D | ASN409 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue MLT B 505 |
| Chain | Residue |
| B | THR124 |
| B | GLY125 |
| B | ALA126 |
| B | GLN128 |
| B | HIS129 |
| B | ALA316 |
| B | GLY317 |
| B | GLU364 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue FMT B 506 |
| Chain | Residue |
| B | GLU74 |
| B | ALA75 |
| B | THR76 |
| B | SER79 |
| B | ALA85 |
| B | ARG86 |
| B | ILE87 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue FMT B 507 |
| Chain | Residue |
| B | LYS47 |
| B | GLU48 |
| B | ARG114 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue FMT B 508 |
| Chain | Residue |
| B | GLU40 |
| B | ALA195 |
| B | ASP196 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue FMT C 501 |
| Chain | Residue |
| C | TYR30 |
| C | VAL60 |
| C | ASP68 |
| C | MET106 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue MLA C 502 |
| Chain | Residue |
| C | TYR181 |
| C | THR185 |
| C | GLY217 |
| C | LEU218 |
| C | GLY219 |
| C | GLY239 |
| C | SER240 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue FMT C 503 |
| Chain | Residue |
| C | MET67 |
| C | MET106 |
| site_id | AD6 |
| Number of Residues | 14 |
| Details | binding site for residue H9V D 501 |
| Chain | Residue |
| C | ASP64 |
| C | GLY66 |
| C | ASP136 |
| D | VAL30 |
| D | PRO31 |
| D | LEU34 |
| D | ILE184 |
| D | ASN185 |
| D | PHE188 |
| D | PHE202 |
| D | PRO208 |
| D | PHE211 |
| D | HIS294 |
| D | HOH630 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue ACT D 502 |
| Chain | Residue |
| D | ARG265 |
| D | LEU266 |
| D | GLY334 |
| D | ARG335 |
| D | ASP337 |
| D | EDO512 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue ACT D 503 |
| Chain | Residue |
| D | GLY351 |
| D | ARG355 |
| D | PHE404 |
| F | LEU165 |
| site_id | AD9 |
| Number of Residues | 2 |
| Details | binding site for residue FMT D 504 |
| Chain | Residue |
| C | GLN144 |
| D | SER23 |
| site_id | AE1 |
| Number of Residues | 3 |
| Details | binding site for residue FMT D 505 |
| Chain | Residue |
| D | ASP12 |
| D | PHE19 |
| D | GLY20 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue FMT D 506 |
| Chain | Residue |
| G | ARG221 |
| D | LEU237 |
| D | PRO238 |
| D | ASP239 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue FMT D 508 |
| Chain | Residue |
| D | GLN80 |
| H | ARG119 |
| H | VAL145 |
| site_id | AE4 |
| Number of Residues | 2 |
| Details | binding site for residue FMT D 509 |
| Chain | Residue |
| D | ASP59 |
| D | GLU225 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue MLT D 511 |
| Chain | Residue |
| D | GLY20 |
| D | GLY21 |
| D | SER23 |
| D | GLY24 |
| D | GLU332 |
| E | GLN231 |
| site_id | AE6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 512 |
| Chain | Residue |
| D | PRO262 |
| D | ACT502 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue ACT D 513 |
| Chain | Residue |
| B | LYS402 |
| B | GLY405 |
| B | ASN409 |
| D | TRP403 |
| site_id | AE8 |
| Number of Residues | 3 |
| Details | binding site for residue ACT D 514 |
| Chain | Residue |
| C | ARG85 |
| D | ASP303 |
| D | GLU304 |
| site_id | AE9 |
| Number of Residues | 15 |
| Details | binding site for residue H9V F 501 |
| Chain | Residue |
| E | ASP64 |
| E | GLY66 |
| E | ASP136 |
| F | VAL30 |
| F | PRO31 |
| F | LEU34 |
| F | ILE184 |
| F | ASN185 |
| F | PHE188 |
| F | TYR200 |
| F | PHE202 |
| F | PRO208 |
| F | PHE211 |
| F | HIS294 |
| F | HOH623 |
| site_id | AF1 |
| Number of Residues | 2 |
| Details | binding site for residue FMT F 502 |
| Chain | Residue |
| F | SER23 |
| F | TYR29 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue FMT F 503 |
| Chain | Residue |
| F | ARG236 |
| F | LEU237 |
| F | PRO238 |
| F | GLY263 |
| site_id | AF3 |
| Number of Residues | 1 |
| Details | binding site for residue FMT F 504 |
| Chain | Residue |
| F | VAL170 |
| site_id | AF4 |
| Number of Residues | 3 |
| Details | binding site for residue FMT F 505 |
| Chain | Residue |
| F | ASP59 |
| F | ILE221 |
| F | GLU225 |
| site_id | AF5 |
| Number of Residues | 4 |
| Details | binding site for residue MLA F 506 |
| Chain | Residue |
| E | ARG85 |
| F | ASP303 |
| F | GLU304 |
| F | ASP305 |
| site_id | AF6 |
| Number of Residues | 10 |
| Details | binding site for residue MLT F 507 |
| Chain | Residue |
| F | LLP101 |
| F | THR124 |
| F | GLY125 |
| F | ALA126 |
| F | GLY127 |
| F | GLN128 |
| F | HIS129 |
| F | ALA316 |
| F | GLY317 |
| F | GLU364 |
| site_id | AF7 |
| Number of Residues | 7 |
| Details | binding site for residue FMT F 508 |
| Chain | Residue |
| F | VAL245 |
| F | GLY246 |
| F | GLU270 |
| F | ALA282 |
| F | THR284 |
| F | TYR320 |
| F | GLY322 |
| site_id | AF8 |
| Number of Residues | 3 |
| Details | binding site for residue FMT G 501 |
| Chain | Residue |
| G | TYR30 |
| G | VAL60 |
| G | ASP68 |
| site_id | AF9 |
| Number of Residues | 2 |
| Details | binding site for residue ACT G 502 |
| Chain | Residue |
| G | GLN144 |
| H | TYR29 |
| site_id | AG1 |
| Number of Residues | 13 |
| Details | binding site for residue H9V H 501 |
| Chain | Residue |
| G | ASP64 |
| G | GLY66 |
| G | ASP136 |
| H | VAL30 |
| H | PRO31 |
| H | LEU34 |
| H | ILE184 |
| H | ASN185 |
| H | PHE188 |
| H | PHE202 |
| H | PRO208 |
| H | PHE211 |
| H | HIS294 |
| site_id | AG2 |
| Number of Residues | 4 |
| Details | binding site for residue FMT H 502 |
| Chain | Residue |
| H | ALA172 |
| H | VAL173 |
| H | GLN174 |
| H | GLU186 |
| site_id | AG3 |
| Number of Residues | 8 |
| Details | binding site for residue MLT H 503 |
| Chain | Residue |
| H | LLP101 |
| H | THR124 |
| H | GLY125 |
| H | ALA126 |
| H | GLY127 |
| H | GLN128 |
| H | HIS129 |
| H | ALA316 |
| site_id | AG4 |
| Number of Residues | 3 |
| Details | binding site for residue ACT H 504 |
| Chain | Residue |
| H | LEU266 |
| H | ARG335 |
| H | ASP337 |
| site_id | AG5 |
| Number of Residues | 1 |
| Details | binding site for residue FMT H 505 |
| Chain | Residue |
| H | ASP239 |
| site_id | AG6 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide MLT D 510 and ALA D 126 |
| Chain | Residue |
| D | LLP101 |
| D | THR124 |
| D | GLY125 |
| D | GLY127 |
| D | GLN128 |
| D | HIS129 |
| D | MET148 |
| D | GLN156 |
| D | ASN159 |
| D | ALA316 |
| D | GLY317 |
Functional Information from PROSITE/UniProt
| site_id | PS00167 |
| Number of Residues | 14 |
| Details | TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. IEVGvPYSDPGMDG |
| Chain | Residue | Details |
| A | ILE56-GLY69 |
| site_id | PS00168 |
| Number of Residues | 15 |
| Details | TRP_SYNTHASE_BETA Tryptophan synthase beta chain pyridoxal-phosphate attachment site. LnHtGSHKiNnvLgQ |
| Chain | Residue | Details |
| B | LEU94-GLN108 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00131","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"HAMAP-Rule","id":"MF_00133","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
