6UAP
Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD6309 bound
Replaces: 6DU1Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000162 | biological_process | tryptophan biosynthetic process |
A | 0004834 | molecular_function | tryptophan synthase activity |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0006568 | biological_process | tryptophan metabolic process |
A | 0016829 | molecular_function | lyase activity |
B | 0000162 | biological_process | tryptophan biosynthetic process |
B | 0004834 | molecular_function | tryptophan synthase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006568 | biological_process | tryptophan metabolic process |
B | 0016829 | molecular_function | lyase activity |
B | 1901605 | biological_process | alpha-amino acid metabolic process |
C | 0000162 | biological_process | tryptophan biosynthetic process |
C | 0004834 | molecular_function | tryptophan synthase activity |
C | 0005829 | cellular_component | cytosol |
C | 0005886 | cellular_component | plasma membrane |
C | 0006568 | biological_process | tryptophan metabolic process |
C | 0016829 | molecular_function | lyase activity |
D | 0000162 | biological_process | tryptophan biosynthetic process |
D | 0004834 | molecular_function | tryptophan synthase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0006568 | biological_process | tryptophan metabolic process |
D | 0016829 | molecular_function | lyase activity |
D | 1901605 | biological_process | alpha-amino acid metabolic process |
E | 0000162 | biological_process | tryptophan biosynthetic process |
E | 0004834 | molecular_function | tryptophan synthase activity |
E | 0005829 | cellular_component | cytosol |
E | 0005886 | cellular_component | plasma membrane |
E | 0006568 | biological_process | tryptophan metabolic process |
E | 0016829 | molecular_function | lyase activity |
F | 0000162 | biological_process | tryptophan biosynthetic process |
F | 0004834 | molecular_function | tryptophan synthase activity |
F | 0005737 | cellular_component | cytoplasm |
F | 0006568 | biological_process | tryptophan metabolic process |
F | 0016829 | molecular_function | lyase activity |
F | 1901605 | biological_process | alpha-amino acid metabolic process |
G | 0000162 | biological_process | tryptophan biosynthetic process |
G | 0004834 | molecular_function | tryptophan synthase activity |
G | 0005829 | cellular_component | cytosol |
G | 0005886 | cellular_component | plasma membrane |
G | 0006568 | biological_process | tryptophan metabolic process |
G | 0016829 | molecular_function | lyase activity |
H | 0000162 | biological_process | tryptophan biosynthetic process |
H | 0004834 | molecular_function | tryptophan synthase activity |
H | 0005737 | cellular_component | cytoplasm |
H | 0006568 | biological_process | tryptophan metabolic process |
H | 0016829 | molecular_function | lyase activity |
H | 1901605 | biological_process | alpha-amino acid metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 2 |
Details | binding site for residue FMT A 501 |
Chain | Residue |
A | MET67 |
A | MET106 |
site_id | AC2 |
Number of Residues | 3 |
Details | binding site for residue FMT A 502 |
Chain | Residue |
A | TYR30 |
A | VAL60 |
A | ASP68 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue EDO A 503 |
Chain | Residue |
A | TYR181 |
A | GLY217 |
A | GLY239 |
A | SER240 |
site_id | AC4 |
Number of Residues | 14 |
Details | binding site for residue H9V B 501 |
Chain | Residue |
A | ASP64 |
A | GLY66 |
A | ASP136 |
B | VAL30 |
B | PRO31 |
B | LEU34 |
B | ILE184 |
B | ASN185 |
B | PHE188 |
B | PHE202 |
B | PRO208 |
B | PHE211 |
B | HIS294 |
B | HOH624 |
site_id | AC5 |
Number of Residues | 2 |
Details | binding site for residue FMT B 502 |
Chain | Residue |
B | SER23 |
B | TYR29 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue FMT B 503 |
Chain | Residue |
B | ARG236 |
B | LEU237 |
B | PRO238 |
B | GLY263 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue MLA B 504 |
Chain | Residue |
B | ASP274 |
B | THR342 |
B | SER344 |
D | ASN409 |
site_id | AC8 |
Number of Residues | 8 |
Details | binding site for residue MLT B 505 |
Chain | Residue |
B | THR124 |
B | GLY125 |
B | ALA126 |
B | GLN128 |
B | HIS129 |
B | ALA316 |
B | GLY317 |
B | GLU364 |
site_id | AC9 |
Number of Residues | 7 |
Details | binding site for residue FMT B 506 |
Chain | Residue |
B | GLU74 |
B | ALA75 |
B | THR76 |
B | SER79 |
B | ALA85 |
B | ARG86 |
B | ILE87 |
site_id | AD1 |
Number of Residues | 3 |
Details | binding site for residue FMT B 507 |
Chain | Residue |
B | LYS47 |
B | GLU48 |
B | ARG114 |
site_id | AD2 |
Number of Residues | 3 |
Details | binding site for residue FMT B 508 |
Chain | Residue |
B | GLU40 |
B | ALA195 |
B | ASP196 |
site_id | AD3 |
Number of Residues | 4 |
Details | binding site for residue FMT C 501 |
Chain | Residue |
C | TYR30 |
C | VAL60 |
C | ASP68 |
C | MET106 |
site_id | AD4 |
Number of Residues | 7 |
Details | binding site for residue MLA C 502 |
Chain | Residue |
C | TYR181 |
C | THR185 |
C | GLY217 |
C | LEU218 |
C | GLY219 |
C | GLY239 |
C | SER240 |
site_id | AD5 |
Number of Residues | 2 |
Details | binding site for residue FMT C 503 |
Chain | Residue |
C | MET67 |
C | MET106 |
site_id | AD6 |
Number of Residues | 14 |
Details | binding site for residue H9V D 501 |
Chain | Residue |
C | ASP64 |
C | GLY66 |
C | ASP136 |
D | VAL30 |
D | PRO31 |
D | LEU34 |
D | ILE184 |
D | ASN185 |
D | PHE188 |
D | PHE202 |
D | PRO208 |
D | PHE211 |
D | HIS294 |
D | HOH630 |
site_id | AD7 |
Number of Residues | 6 |
Details | binding site for residue ACT D 502 |
Chain | Residue |
D | ARG265 |
D | LEU266 |
D | GLY334 |
D | ARG335 |
D | ASP337 |
D | EDO512 |
site_id | AD8 |
Number of Residues | 4 |
Details | binding site for residue ACT D 503 |
Chain | Residue |
D | GLY351 |
D | ARG355 |
D | PHE404 |
F | LEU165 |
site_id | AD9 |
Number of Residues | 2 |
Details | binding site for residue FMT D 504 |
Chain | Residue |
C | GLN144 |
D | SER23 |
site_id | AE1 |
Number of Residues | 3 |
Details | binding site for residue FMT D 505 |
Chain | Residue |
D | ASP12 |
D | PHE19 |
D | GLY20 |
site_id | AE2 |
Number of Residues | 4 |
Details | binding site for residue FMT D 506 |
Chain | Residue |
G | ARG221 |
D | LEU237 |
D | PRO238 |
D | ASP239 |
site_id | AE3 |
Number of Residues | 3 |
Details | binding site for residue FMT D 508 |
Chain | Residue |
D | GLN80 |
H | ARG119 |
H | VAL145 |
site_id | AE4 |
Number of Residues | 2 |
Details | binding site for residue FMT D 509 |
Chain | Residue |
D | ASP59 |
D | GLU225 |
site_id | AE5 |
Number of Residues | 6 |
Details | binding site for residue MLT D 511 |
Chain | Residue |
D | GLY20 |
D | GLY21 |
D | SER23 |
D | GLY24 |
D | GLU332 |
E | GLN231 |
site_id | AE6 |
Number of Residues | 2 |
Details | binding site for residue EDO D 512 |
Chain | Residue |
D | PRO262 |
D | ACT502 |
site_id | AE7 |
Number of Residues | 4 |
Details | binding site for residue ACT D 513 |
Chain | Residue |
B | LYS402 |
B | GLY405 |
B | ASN409 |
D | TRP403 |
site_id | AE8 |
Number of Residues | 3 |
Details | binding site for residue ACT D 514 |
Chain | Residue |
C | ARG85 |
D | ASP303 |
D | GLU304 |
site_id | AE9 |
Number of Residues | 15 |
Details | binding site for residue H9V F 501 |
Chain | Residue |
E | ASP64 |
E | GLY66 |
E | ASP136 |
F | VAL30 |
F | PRO31 |
F | LEU34 |
F | ILE184 |
F | ASN185 |
F | PHE188 |
F | TYR200 |
F | PHE202 |
F | PRO208 |
F | PHE211 |
F | HIS294 |
F | HOH623 |
site_id | AF1 |
Number of Residues | 2 |
Details | binding site for residue FMT F 502 |
Chain | Residue |
F | SER23 |
F | TYR29 |
site_id | AF2 |
Number of Residues | 4 |
Details | binding site for residue FMT F 503 |
Chain | Residue |
F | ARG236 |
F | LEU237 |
F | PRO238 |
F | GLY263 |
site_id | AF3 |
Number of Residues | 1 |
Details | binding site for residue FMT F 504 |
Chain | Residue |
F | VAL170 |
site_id | AF4 |
Number of Residues | 3 |
Details | binding site for residue FMT F 505 |
Chain | Residue |
F | ASP59 |
F | ILE221 |
F | GLU225 |
site_id | AF5 |
Number of Residues | 4 |
Details | binding site for residue MLA F 506 |
Chain | Residue |
E | ARG85 |
F | ASP303 |
F | GLU304 |
F | ASP305 |
site_id | AF6 |
Number of Residues | 10 |
Details | binding site for residue MLT F 507 |
Chain | Residue |
F | LLP101 |
F | THR124 |
F | GLY125 |
F | ALA126 |
F | GLY127 |
F | GLN128 |
F | HIS129 |
F | ALA316 |
F | GLY317 |
F | GLU364 |
site_id | AF7 |
Number of Residues | 7 |
Details | binding site for residue FMT F 508 |
Chain | Residue |
F | VAL245 |
F | GLY246 |
F | GLU270 |
F | ALA282 |
F | THR284 |
F | TYR320 |
F | GLY322 |
site_id | AF8 |
Number of Residues | 3 |
Details | binding site for residue FMT G 501 |
Chain | Residue |
G | TYR30 |
G | VAL60 |
G | ASP68 |
site_id | AF9 |
Number of Residues | 2 |
Details | binding site for residue ACT G 502 |
Chain | Residue |
G | GLN144 |
H | TYR29 |
site_id | AG1 |
Number of Residues | 13 |
Details | binding site for residue H9V H 501 |
Chain | Residue |
G | ASP64 |
G | GLY66 |
G | ASP136 |
H | VAL30 |
H | PRO31 |
H | LEU34 |
H | ILE184 |
H | ASN185 |
H | PHE188 |
H | PHE202 |
H | PRO208 |
H | PHE211 |
H | HIS294 |
site_id | AG2 |
Number of Residues | 4 |
Details | binding site for residue FMT H 502 |
Chain | Residue |
H | ALA172 |
H | VAL173 |
H | GLN174 |
H | GLU186 |
site_id | AG3 |
Number of Residues | 8 |
Details | binding site for residue MLT H 503 |
Chain | Residue |
H | LLP101 |
H | THR124 |
H | GLY125 |
H | ALA126 |
H | GLY127 |
H | GLN128 |
H | HIS129 |
H | ALA316 |
site_id | AG4 |
Number of Residues | 3 |
Details | binding site for residue ACT H 504 |
Chain | Residue |
H | LEU266 |
H | ARG335 |
H | ASP337 |
site_id | AG5 |
Number of Residues | 1 |
Details | binding site for residue FMT H 505 |
Chain | Residue |
H | ASP239 |
site_id | AG6 |
Number of Residues | 11 |
Details | binding site for Di-peptide MLT D 510 and ALA D 126 |
Chain | Residue |
D | LLP101 |
D | THR124 |
D | GLY125 |
D | GLY127 |
D | GLN128 |
D | HIS129 |
D | MET148 |
D | GLN156 |
D | ASN159 |
D | ALA316 |
D | GLY317 |
Functional Information from PROSITE/UniProt
site_id | PS00167 |
Number of Residues | 14 |
Details | TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. IEVGvPYSDPGMDG |
Chain | Residue | Details |
A | ILE56-GLY69 |
site_id | PS00168 |
Number of Residues | 15 |
Details | TRP_SYNTHASE_BETA Tryptophan synthase beta chain pyridoxal-phosphate attachment site. LnHtGSHKiNnvLgQ |
Chain | Residue | Details |
B | LEU94-GLN108 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000255|HAMAP-Rule:MF_00133 |
Chain | Residue | Details |
B | HIS100 | |
D | HIS100 | |
F | HIS100 | |
H | HIS100 | |
E | GLU57 | |
E | ASP68 | |
G | GLU57 | |
G | ASP68 |