6U9W

Cryo electron microscopy structure of the ATP-gated rat P2X7 ion channel in the ATP-bound, open state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	P2X purinoceptor 7	polymer	609	69904.0	3	UniProt (Q64663) Pfam (PF00864) Pfam (PF20478)	Rattus norvegicus (Rat)	P2X7,ATP receptor,P2Z receptor,Purinergic receptor
2	D, E, F, G, H... (D, E, F, G, H...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	6	In PDB GlyTouCan (G42666HT)
3	GA, HA, J, K, U... (C, A, B)	ZINC ION	non-polymer		65.4	6	Chemie (ZN)
4	IA, L, W (C, A, B)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	3	Chemie (GDP)
5	JA, KA, M, N, X... (C, A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
6	LA, O, Z (C, A, B)	O-[(R)-[(2S)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-D-serine	non-polymer		764.0	3	Chemie (Q3G)
7	AA, BA, CA, DA, MA... (B, C, A)	PALMITIC ACID	non-polymer		256.4	12	Chemie (PLM)
8	EA, FA, T (B, C, A)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	3	Chemie (ATP)

Sequence modifications

A, B, C: 1 - 595 (UniProt: Q64663)

PDB	External Database	Details
Ser 596	-	expression tag
Asn 597	-	expression tag
Ser 598	-	expression tag
Ala 599	-	expression tag
Val 600	-	expression tag
Asp 601	-	expression tag
Ala 602	-	expression tag
Gly 603	-	expression tag
Leu 604	-	expression tag
Glu 605	-	expression tag
Val 606	-	expression tag
Leu 607	-	expression tag
Phe 608	-	expression tag
Gln 609	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	209712.0
Branched	Number of molecules	6
	Total formula weight	2546.4
Non-Polymers*	Number of molecules	33
	Total formula weight	9940.0
All*	Total formula weight	222198.5

*Water molecules are not included.