6U9W

Cryo electron microscopy structure of the ATP-gated rat P2X7 ion channel in the ATP-bound, open state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	P2X purinoceptor 7	polymer	609	69904.0	3	UniProt (Q64663) Pfam (PF00864) Pfam (PF20478) In PDB	Rattus norvegicus (Rat)	P2X7,ATP receptor,P2Z receptor,Purinergic receptor
2	D, E, F, G, H...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	6	In PDB GlyTouCan (G42666HT)
3	C, A, B	ZINC ION	non-polymer		65.4	6	Chemie (ZN)
4	C, A, B	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	3	Chemie (GDP)
5	C, A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
6	C, A, B	O-[(R)-[(2S)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-D-serine	non-polymer		764.0	3	Chemie (Q3G)
7	B, C, A	PALMITIC ACID	non-polymer		256.4	12	Chemie (PLM)
8	B, C, A	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	3	Chemie (ATP)

Sequence modifications

A, B, C: 1 - 595 (UniProt: Q64663)

PDB	External Database	Details
Ser 596	-	expression tag
Asn 597	-	expression tag
Ser 598	-	expression tag
Ala 599	-	expression tag
Val 600	-	expression tag
Asp 601	-	expression tag
Ala 602	-	expression tag
Gly 603	-	expression tag
Leu 604	-	expression tag
Glu 605	-	expression tag
Val 606	-	expression tag
Leu 607	-	expression tag
Phe 608	-	expression tag
Gln 609	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	209712.0
Branched	Number of molecules	6
	Total formula weight	2546.4
Non-Polymers*	Number of molecules	33
	Total formula weight	9940.0
All*	Total formula weight	222198.5

*Water molecules are not included.