Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6U9W

Cryo electron microscopy structure of the ATP-gated rat P2X7 ion channel in the ATP-bound, open state

Functional Information from GO Data
ChainGOidnamespacecontents
A0000165biological_processMAPK cascade
A0000287molecular_functionmagnesium ion binding
A0000902biological_processcell morphogenesis
A0001530molecular_functionlipopolysaccharide binding
A0001614molecular_functionpurinergic nucleotide receptor activity
A0001845biological_processphagolysosome assembly
A0001913biological_processT cell mediated cytotoxicity
A0001916biological_processpositive regulation of T cell mediated cytotoxicity
A0001934biological_processpositive regulation of protein phosphorylation
A0002028biological_processregulation of sodium ion transport
A0004931molecular_functionextracellularly ATP-gated monoatomic cation channel activity
A0005102molecular_functionsignaling receptor binding
A0005216molecular_functionmonoatomic ion channel activity
A0005507molecular_functioncopper ion binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005635cellular_componentnuclear envelope
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005886cellular_componentplasma membrane
A0005911cellular_componentcell-cell junction
A0006509biological_processmembrane protein ectodomain proteolysis
A0006649biological_processphospholipid transfer to membrane
A0006811biological_processmonoatomic ion transport
A0006812biological_processmonoatomic cation transport
A0006816biological_processcalcium ion transport
A0006884biological_processcell volume homeostasis
A0006900biological_processvesicle budding from membrane
A0006954biological_processinflammatory response
A0007005biological_processmitochondrion organization
A0007009biological_processplasma membrane organization
A0007166biological_processcell surface receptor signaling pathway
A0008270molecular_functionzinc ion binding
A0009306biological_processprotein secretion
A0009410biological_processresponse to xenobiotic stimulus
A0009612biological_processresponse to mechanical stimulus
A0009617biological_processresponse to bacterium
A0009897cellular_componentexternal side of plasma membrane
A0010043biological_processresponse to zinc ion
A0010467biological_processgene expression
A0010524biological_processpositive regulation of calcium ion transport into cytosol
A0010628biological_processpositive regulation of gene expression
A0012501biological_processprogrammed cell death
A0014047biological_processglutamate secretion
A0014049biological_processpositive regulation of glutamate secretion
A0014051biological_processgamma-aminobutyric acid secretion
A0014054biological_processpositive regulation of gamma-aminobutyric acid secretion
A0014070biological_processresponse to organic cyclic compound
A0015267molecular_functionchannel activity
A0016020cellular_componentmembrane
A0016079biological_processsynaptic vesicle exocytosis
A0016485biological_processprotein processing
A0017121biological_processplasma membrane phospholipid scrambling
A0019228biological_processneuronal action potential
A0019233biological_processsensory perception of pain
A0030163biological_processprotein catabolic process
A0030501biological_processpositive regulation of bone mineralization
A0031594cellular_componentneuromuscular junction
A0032059cellular_componentbleb
A0032060biological_processbleb assembly
A0032308biological_processpositive regulation of prostaglandin secretion
A0032310biological_processprostaglandin secretion
A0032496biological_processresponse to lipopolysaccharide
A0032730biological_processpositive regulation of interleukin-1 alpha production
A0032731biological_processpositive regulation of interleukin-1 beta production
A0032755biological_processpositive regulation of interleukin-6 production
A0032963biological_processcollagen metabolic process
A0032991cellular_componentprotein-containing complex
A0033198biological_processresponse to ATP
A0034220biological_processmonoatomic ion transmembrane transport
A0034405biological_processresponse to fluid shear stress
A0034767biological_processpositive regulation of monoatomic ion transmembrane transport
A0035590biological_processpurinergic nucleotide receptor signaling pathway
A0038023molecular_functionsignaling receptor activity
A0042098biological_processT cell proliferation
A0042802molecular_functionidentical protein binding
A0043025cellular_componentneuronal cell body
A0043029biological_processT cell homeostasis
A0043065biological_processpositive regulation of apoptotic process
A0043132biological_processNAD transport
A0043195cellular_componentterminal bouton
A0043409biological_processnegative regulation of MAPK cascade
A0043410biological_processpositive regulation of MAPK cascade
A0043539molecular_functionprotein serine/threonine kinase activator activity
A0045202cellular_componentsynapse
A0045332biological_processphospholipid translocation
A0045778biological_processpositive regulation of ossification
A0045779biological_processnegative regulation of bone resorption
A0045794biological_processnegative regulation of cell volume
A0045821biological_processpositive regulation of glycolytic process
A0046513biological_processceramide biosynthetic process
A0046931biological_processpore complex assembly
A0048705biological_processskeletal system morphogenesis
A0048873biological_processhomeostasis of number of cells within a tissue
A0050714biological_processpositive regulation of protein secretion
A0050830biological_processdefense response to Gram-positive bacterium
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051495biological_processpositive regulation of cytoskeleton organization
A0051592biological_processresponse to calcium ion
A0051602biological_processresponse to electrical stimulus
A0051649biological_processestablishment of localization in cell
A0051882biological_processmitochondrial depolarization
A0051899biological_processmembrane depolarization
A0051901biological_processpositive regulation of mitochondrial depolarization
A0060079biological_processexcitatory postsynaptic potential
A0060907biological_processpositive regulation of macrophage cytokine production
A0070227biological_processlymphocyte apoptotic process
A0070230biological_processpositive regulation of lymphocyte apoptotic process
A0070231biological_processT cell apoptotic process
A0070234biological_processpositive regulation of T cell apoptotic process
A0070588biological_processcalcium ion transmembrane transport
A0071359biological_processcellular response to dsRNA
A0071407biological_processcellular response to organic cyclic compound
A0072593biological_processreactive oxygen species metabolic process
A0097110molecular_functionscaffold protein binding
A0097190biological_processapoptotic signaling pathway
A0097191biological_processextrinsic apoptotic signaling pathway
A0098655biological_processmonoatomic cation transmembrane transport
A0098794cellular_componentpostsynapse
A0099161biological_processregulation of presynaptic dense core granule exocytosis
A1904172biological_processpositive regulation of bleb assembly
A1904669biological_processATP export
B0000165biological_processMAPK cascade
B0000287molecular_functionmagnesium ion binding
B0000902biological_processcell morphogenesis
B0001530molecular_functionlipopolysaccharide binding
B0001614molecular_functionpurinergic nucleotide receptor activity
B0001845biological_processphagolysosome assembly
B0001913biological_processT cell mediated cytotoxicity
B0001916biological_processpositive regulation of T cell mediated cytotoxicity
B0001934biological_processpositive regulation of protein phosphorylation
B0002028biological_processregulation of sodium ion transport
B0004931molecular_functionextracellularly ATP-gated monoatomic cation channel activity
B0005102molecular_functionsignaling receptor binding
B0005216molecular_functionmonoatomic ion channel activity
B0005507molecular_functioncopper ion binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005635cellular_componentnuclear envelope
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005886cellular_componentplasma membrane
B0005911cellular_componentcell-cell junction
B0006509biological_processmembrane protein ectodomain proteolysis
B0006649biological_processphospholipid transfer to membrane
B0006811biological_processmonoatomic ion transport
B0006812biological_processmonoatomic cation transport
B0006816biological_processcalcium ion transport
B0006884biological_processcell volume homeostasis
B0006900biological_processvesicle budding from membrane
B0006954biological_processinflammatory response
B0007005biological_processmitochondrion organization
B0007009biological_processplasma membrane organization
B0007166biological_processcell surface receptor signaling pathway
B0008270molecular_functionzinc ion binding
B0009306biological_processprotein secretion
B0009410biological_processresponse to xenobiotic stimulus
B0009612biological_processresponse to mechanical stimulus
B0009617biological_processresponse to bacterium
B0009897cellular_componentexternal side of plasma membrane
B0010043biological_processresponse to zinc ion
B0010467biological_processgene expression
B0010524biological_processpositive regulation of calcium ion transport into cytosol
B0010628biological_processpositive regulation of gene expression
B0012501biological_processprogrammed cell death
B0014047biological_processglutamate secretion
B0014049biological_processpositive regulation of glutamate secretion
B0014051biological_processgamma-aminobutyric acid secretion
B0014054biological_processpositive regulation of gamma-aminobutyric acid secretion
B0014070biological_processresponse to organic cyclic compound
B0015267molecular_functionchannel activity
B0016020cellular_componentmembrane
B0016079biological_processsynaptic vesicle exocytosis
B0016485biological_processprotein processing
B0017121biological_processplasma membrane phospholipid scrambling
B0019228biological_processneuronal action potential
B0019233biological_processsensory perception of pain
B0030163biological_processprotein catabolic process
B0030501biological_processpositive regulation of bone mineralization
B0031594cellular_componentneuromuscular junction
B0032059cellular_componentbleb
B0032060biological_processbleb assembly
B0032308biological_processpositive regulation of prostaglandin secretion
B0032310biological_processprostaglandin secretion
B0032496biological_processresponse to lipopolysaccharide
B0032730biological_processpositive regulation of interleukin-1 alpha production
B0032731biological_processpositive regulation of interleukin-1 beta production
B0032755biological_processpositive regulation of interleukin-6 production
B0032963biological_processcollagen metabolic process
B0032991cellular_componentprotein-containing complex
B0033198biological_processresponse to ATP
B0034220biological_processmonoatomic ion transmembrane transport
B0034405biological_processresponse to fluid shear stress
B0034767biological_processpositive regulation of monoatomic ion transmembrane transport
B0035590biological_processpurinergic nucleotide receptor signaling pathway
B0038023molecular_functionsignaling receptor activity
B0042098biological_processT cell proliferation
B0042802molecular_functionidentical protein binding
B0043025cellular_componentneuronal cell body
B0043029biological_processT cell homeostasis
B0043065biological_processpositive regulation of apoptotic process
B0043132biological_processNAD transport
B0043195cellular_componentterminal bouton
B0043409biological_processnegative regulation of MAPK cascade
B0043410biological_processpositive regulation of MAPK cascade
B0043539molecular_functionprotein serine/threonine kinase activator activity
B0045202cellular_componentsynapse
B0045332biological_processphospholipid translocation
B0045778biological_processpositive regulation of ossification
B0045779biological_processnegative regulation of bone resorption
B0045794biological_processnegative regulation of cell volume
B0045821biological_processpositive regulation of glycolytic process
B0046513biological_processceramide biosynthetic process
B0046931biological_processpore complex assembly
B0048705biological_processskeletal system morphogenesis
B0048873biological_processhomeostasis of number of cells within a tissue
B0050714biological_processpositive regulation of protein secretion
B0050830biological_processdefense response to Gram-positive bacterium
B0051209biological_processrelease of sequestered calcium ion into cytosol
B0051495biological_processpositive regulation of cytoskeleton organization
B0051592biological_processresponse to calcium ion
B0051602biological_processresponse to electrical stimulus
B0051649biological_processestablishment of localization in cell
B0051882biological_processmitochondrial depolarization
B0051899biological_processmembrane depolarization
B0051901biological_processpositive regulation of mitochondrial depolarization
B0060079biological_processexcitatory postsynaptic potential
B0060907biological_processpositive regulation of macrophage cytokine production
B0070227biological_processlymphocyte apoptotic process
B0070230biological_processpositive regulation of lymphocyte apoptotic process
B0070231biological_processT cell apoptotic process
B0070234biological_processpositive regulation of T cell apoptotic process
B0070588biological_processcalcium ion transmembrane transport
B0071359biological_processcellular response to dsRNA
B0071407biological_processcellular response to organic cyclic compound
B0072593biological_processreactive oxygen species metabolic process
B0097110molecular_functionscaffold protein binding
B0097190biological_processapoptotic signaling pathway
B0097191biological_processextrinsic apoptotic signaling pathway
B0098655biological_processmonoatomic cation transmembrane transport
B0098794cellular_componentpostsynapse
B0099161biological_processregulation of presynaptic dense core granule exocytosis
B1904172biological_processpositive regulation of bleb assembly
B1904669biological_processATP export
C0000165biological_processMAPK cascade
C0000287molecular_functionmagnesium ion binding
C0000902biological_processcell morphogenesis
C0001530molecular_functionlipopolysaccharide binding
C0001614molecular_functionpurinergic nucleotide receptor activity
C0001845biological_processphagolysosome assembly
C0001913biological_processT cell mediated cytotoxicity
C0001916biological_processpositive regulation of T cell mediated cytotoxicity
C0001934biological_processpositive regulation of protein phosphorylation
C0002028biological_processregulation of sodium ion transport
C0004931molecular_functionextracellularly ATP-gated monoatomic cation channel activity
C0005102molecular_functionsignaling receptor binding
C0005216molecular_functionmonoatomic ion channel activity
C0005507molecular_functioncopper ion binding
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005635cellular_componentnuclear envelope
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005886cellular_componentplasma membrane
C0005911cellular_componentcell-cell junction
C0006509biological_processmembrane protein ectodomain proteolysis
C0006649biological_processphospholipid transfer to membrane
C0006811biological_processmonoatomic ion transport
C0006812biological_processmonoatomic cation transport
C0006816biological_processcalcium ion transport
C0006884biological_processcell volume homeostasis
C0006900biological_processvesicle budding from membrane
C0006954biological_processinflammatory response
C0007005biological_processmitochondrion organization
C0007009biological_processplasma membrane organization
C0007166biological_processcell surface receptor signaling pathway
C0008270molecular_functionzinc ion binding
C0009306biological_processprotein secretion
C0009410biological_processresponse to xenobiotic stimulus
C0009612biological_processresponse to mechanical stimulus
C0009617biological_processresponse to bacterium
C0009897cellular_componentexternal side of plasma membrane
C0010043biological_processresponse to zinc ion
C0010467biological_processgene expression
C0010524biological_processpositive regulation of calcium ion transport into cytosol
C0010628biological_processpositive regulation of gene expression
C0012501biological_processprogrammed cell death
C0014047biological_processglutamate secretion
C0014049biological_processpositive regulation of glutamate secretion
C0014051biological_processgamma-aminobutyric acid secretion
C0014054biological_processpositive regulation of gamma-aminobutyric acid secretion
C0014070biological_processresponse to organic cyclic compound
C0015267molecular_functionchannel activity
C0016020cellular_componentmembrane
C0016079biological_processsynaptic vesicle exocytosis
C0016485biological_processprotein processing
C0017121biological_processplasma membrane phospholipid scrambling
C0019228biological_processneuronal action potential
C0019233biological_processsensory perception of pain
C0030163biological_processprotein catabolic process
C0030501biological_processpositive regulation of bone mineralization
C0031594cellular_componentneuromuscular junction
C0032059cellular_componentbleb
C0032060biological_processbleb assembly
C0032308biological_processpositive regulation of prostaglandin secretion
C0032310biological_processprostaglandin secretion
C0032496biological_processresponse to lipopolysaccharide
C0032730biological_processpositive regulation of interleukin-1 alpha production
C0032731biological_processpositive regulation of interleukin-1 beta production
C0032755biological_processpositive regulation of interleukin-6 production
C0032963biological_processcollagen metabolic process
C0032991cellular_componentprotein-containing complex
C0033198biological_processresponse to ATP
C0034220biological_processmonoatomic ion transmembrane transport
C0034405biological_processresponse to fluid shear stress
C0034767biological_processpositive regulation of monoatomic ion transmembrane transport
C0035590biological_processpurinergic nucleotide receptor signaling pathway
C0038023molecular_functionsignaling receptor activity
C0042098biological_processT cell proliferation
C0042802molecular_functionidentical protein binding
C0043025cellular_componentneuronal cell body
C0043029biological_processT cell homeostasis
C0043065biological_processpositive regulation of apoptotic process
C0043132biological_processNAD transport
C0043195cellular_componentterminal bouton
C0043409biological_processnegative regulation of MAPK cascade
C0043410biological_processpositive regulation of MAPK cascade
C0043539molecular_functionprotein serine/threonine kinase activator activity
C0045202cellular_componentsynapse
C0045332biological_processphospholipid translocation
C0045778biological_processpositive regulation of ossification
C0045779biological_processnegative regulation of bone resorption
C0045794biological_processnegative regulation of cell volume
C0045821biological_processpositive regulation of glycolytic process
C0046513biological_processceramide biosynthetic process
C0046931biological_processpore complex assembly
C0048705biological_processskeletal system morphogenesis
C0048873biological_processhomeostasis of number of cells within a tissue
C0050714biological_processpositive regulation of protein secretion
C0050830biological_processdefense response to Gram-positive bacterium
C0051209biological_processrelease of sequestered calcium ion into cytosol
C0051495biological_processpositive regulation of cytoskeleton organization
C0051592biological_processresponse to calcium ion
C0051602biological_processresponse to electrical stimulus
C0051649biological_processestablishment of localization in cell
C0051882biological_processmitochondrial depolarization
C0051899biological_processmembrane depolarization
C0051901biological_processpositive regulation of mitochondrial depolarization
C0060079biological_processexcitatory postsynaptic potential
C0060907biological_processpositive regulation of macrophage cytokine production
C0070227biological_processlymphocyte apoptotic process
C0070230biological_processpositive regulation of lymphocyte apoptotic process
C0070231biological_processT cell apoptotic process
C0070234biological_processpositive regulation of T cell apoptotic process
C0070588biological_processcalcium ion transmembrane transport
C0071359biological_processcellular response to dsRNA
C0071407biological_processcellular response to organic cyclic compound
C0072593biological_processreactive oxygen species metabolic process
C0097110molecular_functionscaffold protein binding
C0097190biological_processapoptotic signaling pathway
C0097191biological_processextrinsic apoptotic signaling pathway
C0098655biological_processmonoatomic cation transmembrane transport
C0098794cellular_componentpostsynapse
C0099161biological_processregulation of presynaptic dense core granule exocytosis
C1904172biological_processpositive regulation of bleb assembly
C1904669biological_processATP export
Functional Information from PROSITE/UniProt
site_idPS01212
Number of Residues27
DetailsP2X_RECEPTOR ATP P2X receptors signature. GGiMGIeIyWdCNLDswshrCqPkYsF
ChainResidueDetails
AGLY249-PHE275

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues789
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-ASN25
AASN356-TYR595
BMET1-ASN25
BASN356-TYR595
CMET1-ASN25
CASN356-TYR595

site_idSWS_FT_FI2
Number of Residues60
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
ATYR26-MET46
BTYR26-MET46
CTYR26-MET46

site_idSWS_FT_FI3
Number of Residues861
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
ASER47-VAL334
BSER47-VAL334
CSER47-VAL334

site_idSWS_FT_FI4
Number of Residues60
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
AVAL335-ILE355
BVAL335-ILE355
CVAL335-ILE355

site_idSWS_FT_FI5
Number of Residues3
DetailsMOD_RES: ADP-ribosylarginine => ECO:0000250
ChainResidueDetails
AARG125
BARG125
CARG125

site_idSWS_FT_FI6
Number of Residues12
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN74
CASN202
CASN241
CASN284
AASN202
AASN241
AASN284
BASN74
BASN202
BASN241
BASN284
CASN74

site_idSWS_FT_FI7
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0007744|PubMed:24090084
ChainResidueDetails
AASN187
AASN213
BASN187
BASN213
CASN187
CASN213

222926

PDB entries from 2024-07-24

PDB statisticsPDBj update infoContact PDBjnumon