6U9V

Cryo electron microscopy structure of the ATP-gated rat P2X7 ion channel in the apo, closed state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	P2X purinoceptor 7	polymer	609	69904.0	3	UniProt (Q64663) Pfam (PF00864) Pfam (PF20478) In PDB	Rattus norvegicus (Rat)
2	D, E, F, G, H...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	6	In PDB GlyTouCan (G42666HT)
3	J, K, L	alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose	branched		342.3	3	In PDB BIRD (PRD_900001) GlyTouCan (G07411ON)		alpha-maltose
4	A, C, B	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	3	Chemie (GDP)
5	B, A, C	ZINC ION	non-polymer		65.4	6	Chemie (ZN)
6	B, A, C	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	9	Chemie (NAG)
7	B, A, C	O-[(R)-[(2S)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-D-serine	non-polymer		764.0	3	Chemie (Q3G)
8	B, A, C	PALMITIC ACID	non-polymer		256.4	18	Chemie (PLM)

Sequence modifications

A, B, C: 1 - 595 (UniProt: Q64663)

PDB	External Database	Details
Ser 596	-	expression tag
Asn 597	-	expression tag
Ser 598	-	expression tag
Ala 599	-	expression tag
Val 600	-	expression tag
Asp 601	-	expression tag
Ala 602	-	expression tag
Gly 603	-	expression tag
Leu 604	-	expression tag
Glu 605	-	expression tag
Val 606	-	expression tag
Leu 607	-	expression tag
Phe 608	-	expression tag
Gln 609	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	209712.0
Branched	Number of molecules	9
	Total formula weight	3573.3
Non-Polymers*	Number of molecules	39
	Total formula weight	10620.6
All*	Total formula weight	223906.0

*Water molecules are not included.