6U6C
Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and GSK2-bound form
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | Tryptophan synthase alpha chain | polymer | 276 | 28579.4 | 4 | UniProt (P9WFY1) Pfam (PF00290) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | |
| 2 | B, D, F, H (B, D, F, H) | Tryptophan synthase beta chain | polymer | 410 | 43334.6 | 4 | UniProt (P9WFX9) Pfam (PF00291) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | |
| 3 | AA, AB, AE, AF, BA... (B, C, H, D, F...) | FORMIC ACID | non-polymer | 46.0 | 92 | Chemie (FMT) | |||
| 4 | BB, BC, BD, CA, DA... (C, D, F, B, H...) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 24 | Chemie (EDO) | |||
| 5 | AD, FE, QC, R, T (F, H, A) | ACETATE ION | non-polymer | 59.0 | 5 | Chemie (ACT) | |||
| 6 | DF, FB, FC, JD, S... (H, C, E, F, A...) | MALONATE ION | non-polymer | 102.0 | 6 | Chemie (MLI) | |||
| 7 | BE, IB, KC, U (H, D, F, B) | 1-(2-fluorobenzene-1-carbonyl)-N-methyl-2,3-dihydro-1H-indole-5-sulfonamide | non-polymer | 334.4 | 4 | Chemie (PZV) | |||
| 8 | DE, MB, NC, V (H, D, F, B) | 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID | non-polymer | 318.2 | 4 | Chemie (P1T) | |||
| 9 | LD, ME, VD, Z (F, H, G, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) | |||
| 10 | AC, DC, EF, GB, ID... (D, H, C, F, B...) | POTASSIUM ION | non-polymer | 39.1 | 8 | Chemie (K) | |||
| 11 | FF, MD, UA, XA (H, F, B) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 4 | Chemie (EPE) | |||
| 12 | EC (E) | ALANINE | non-polymer | 89.1 | 1 | Chemie (ALA) | |||
| 13 | JC, RC (F) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 14 | HD (F) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 15 | HF, IF, JF, KF, LF... (A, B, C, D, E...) | water | water | 18.0 | 1195 | Chemie (HOH) |
Sequence modifications
A, C, E, G: 1 - 270 (UniProt: P9WFY1)
| PDB | External Database | Details |
|---|---|---|
| His 271 | - | expression tag |
| His 272 | - | expression tag |
| His 273 | - | expression tag |
| His 274 | - | expression tag |
| His 275 | - | expression tag |
| His 276 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 287656.2 | |
| Non-Polymers* | Number of molecules | 155 |
| Total formula weight | 11344.7 | |
| All* | Total formula weight | 299000.9 |
