6U6C
Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and GSK2-bound form
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000162 | biological_process | tryptophan biosynthetic process |
A | 0004834 | molecular_function | tryptophan synthase activity |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0006568 | biological_process | tryptophan metabolic process |
A | 0016829 | molecular_function | lyase activity |
B | 0000162 | biological_process | tryptophan biosynthetic process |
B | 0004834 | molecular_function | tryptophan synthase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006568 | biological_process | tryptophan metabolic process |
B | 0016829 | molecular_function | lyase activity |
B | 1901605 | biological_process | alpha-amino acid metabolic process |
C | 0000162 | biological_process | tryptophan biosynthetic process |
C | 0004834 | molecular_function | tryptophan synthase activity |
C | 0005829 | cellular_component | cytosol |
C | 0005886 | cellular_component | plasma membrane |
C | 0006568 | biological_process | tryptophan metabolic process |
C | 0016829 | molecular_function | lyase activity |
D | 0000162 | biological_process | tryptophan biosynthetic process |
D | 0004834 | molecular_function | tryptophan synthase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0006568 | biological_process | tryptophan metabolic process |
D | 0016829 | molecular_function | lyase activity |
D | 1901605 | biological_process | alpha-amino acid metabolic process |
E | 0000162 | biological_process | tryptophan biosynthetic process |
E | 0004834 | molecular_function | tryptophan synthase activity |
E | 0005829 | cellular_component | cytosol |
E | 0005886 | cellular_component | plasma membrane |
E | 0006568 | biological_process | tryptophan metabolic process |
E | 0016829 | molecular_function | lyase activity |
F | 0000162 | biological_process | tryptophan biosynthetic process |
F | 0004834 | molecular_function | tryptophan synthase activity |
F | 0005737 | cellular_component | cytoplasm |
F | 0006568 | biological_process | tryptophan metabolic process |
F | 0016829 | molecular_function | lyase activity |
F | 1901605 | biological_process | alpha-amino acid metabolic process |
G | 0000162 | biological_process | tryptophan biosynthetic process |
G | 0004834 | molecular_function | tryptophan synthase activity |
G | 0005829 | cellular_component | cytosol |
G | 0005886 | cellular_component | plasma membrane |
G | 0006568 | biological_process | tryptophan metabolic process |
G | 0016829 | molecular_function | lyase activity |
H | 0000162 | biological_process | tryptophan biosynthetic process |
H | 0004834 | molecular_function | tryptophan synthase activity |
H | 0005737 | cellular_component | cytoplasm |
H | 0006568 | biological_process | tryptophan metabolic process |
H | 0016829 | molecular_function | lyase activity |
H | 1901605 | biological_process | alpha-amino acid metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | binding site for residue FMT A 301 |
Chain | Residue |
A | GLY83 |
A | ARG85 |
A | ASP88 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue FMT A 302 |
Chain | Residue |
A | GLU57 |
A | MET106 |
A | TYR181 |
A | ILE237 |
A | MLI311 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue FMT A 303 |
Chain | Residue |
A | GLY116 |
A | VAL117 |
A | GLN144 |
A | HOH434 |
A | LEU113 |
site_id | AC4 |
Number of Residues | 3 |
Details | binding site for residue EDO A 304 |
Chain | Residue |
A | TYR35 |
A | PRO36 |
A | HOH436 |
site_id | AC5 |
Number of Residues | 3 |
Details | binding site for residue FMT A 305 |
Chain | Residue |
A | ASP140 |
A | ALA171 |
A | HOH464 |
site_id | AC6 |
Number of Residues | 1 |
Details | binding site for residue FMT A 306 |
Chain | Residue |
A | ARG11 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue FMT A 307 |
Chain | Residue |
A | GLY69 |
A | PRO70 |
A | THR71 |
A | HOH430 |
A | HOH442 |
site_id | AC8 |
Number of Residues | 2 |
Details | binding site for residue FMT A 308 |
Chain | Residue |
A | MET67 |
A | MET106 |
site_id | AC9 |
Number of Residues | 5 |
Details | binding site for residue FMT A 309 |
Chain | Residue |
A | TYR30 |
A | VAL60 |
A | ASP68 |
A | MET106 |
A | HOH445 |
site_id | AD1 |
Number of Residues | 5 |
Details | binding site for residue ACT A 310 |
Chain | Residue |
A | PRO162 |
A | SER164 |
A | THR165 |
A | PRO166 |
A | ARG205 |
site_id | AD2 |
Number of Residues | 10 |
Details | binding site for residue MLI A 311 |
Chain | Residue |
A | TYR181 |
A | GLY217 |
A | LEU218 |
A | GLY219 |
A | GLY239 |
A | SER240 |
A | FMT302 |
A | HOH401 |
A | HOH417 |
A | HOH426 |
site_id | AD3 |
Number of Residues | 4 |
Details | binding site for residue ACT A 312 |
Chain | Residue |
A | LEU113 |
A | GLN144 |
B | SER23 |
B | PHE297 |
site_id | AD4 |
Number of Residues | 17 |
Details | binding site for residue PZV B 501 |
Chain | Residue |
A | TYR62 |
A | ASP64 |
A | GLY66 |
A | MET67 |
A | TYR108 |
A | ASP136 |
B | TYR29 |
B | VAL30 |
B | ILE184 |
B | PHE188 |
B | TRP191 |
B | TYR200 |
B | PHE202 |
B | GLY207 |
B | PRO208 |
B | HIS294 |
B | GLY295 |
site_id | AD5 |
Number of Residues | 18 |
Details | binding site for residue P1T B 502 |
Chain | Residue |
B | HIS100 |
B | LYS101 |
B | THR124 |
B | GLY125 |
B | ALA126 |
B | GLY127 |
B | GLN128 |
B | HIS129 |
B | THR204 |
B | GLY246 |
B | GLY247 |
B | GLY248 |
B | SER249 |
B | ASN250 |
B | GLY317 |
B | GLU364 |
B | SER390 |
B | HOH640 |
site_id | AD6 |
Number of Residues | 4 |
Details | binding site for residue EDO B 503 |
Chain | Residue |
B | VAL171 |
B | ALA172 |
B | GLN174 |
B | GLU186 |
site_id | AD7 |
Number of Residues | 3 |
Details | binding site for residue FMT B 504 |
Chain | Residue |
A | THR165 |
B | ALA36 |
B | GLU39 |
site_id | AD8 |
Number of Residues | 2 |
Details | binding site for residue FMT B 505 |
Chain | Residue |
B | HIS81 |
B | HOH607 |
site_id | AD9 |
Number of Residues | 7 |
Details | binding site for residue PEG B 506 |
Chain | Residue |
B | GLU48 |
B | ARG114 |
B | HOH731 |
B | GLU40 |
B | ALA43 |
B | ALA44 |
B | LYS47 |
site_id | AE1 |
Number of Residues | 4 |
Details | binding site for residue FMT B 507 |
Chain | Residue |
B | HIS312 |
B | SER313 |
B | ASP319 |
B | HOH706 |
site_id | AE2 |
Number of Residues | 2 |
Details | binding site for residue FMT B 508 |
Chain | Residue |
B | ASP274 |
B | ASP343 |
site_id | AE3 |
Number of Residues | 6 |
Details | binding site for residue EDO B 509 |
Chain | Residue |
B | ARG236 |
B | LEU237 |
B | PRO238 |
B | ASP239 |
B | GLY263 |
B | HOH691 |
site_id | AE4 |
Number of Residues | 5 |
Details | binding site for residue EDO B 510 |
Chain | Residue |
B | ASP59 |
B | GLN62 |
B | ARG68 |
B | ILE221 |
B | GLU225 |
site_id | AE5 |
Number of Residues | 5 |
Details | binding site for residue EDO B 511 |
Chain | Residue |
B | GLU40 |
B | LYS117 |
B | ALA195 |
B | ASP196 |
B | HOH625 |
site_id | AE6 |
Number of Residues | 3 |
Details | binding site for residue FMT B 512 |
Chain | Residue |
B | GLY334 |
B | ASP337 |
B | FMT518 |
site_id | AE7 |
Number of Residues | 3 |
Details | binding site for residue FMT B 513 |
Chain | Residue |
B | ARG164 |
B | ALA168 |
B | HOH752 |
site_id | AE8 |
Number of Residues | 7 |
Details | binding site for residue FMT B 514 |
Chain | Residue |
B | ARG155 |
B | GLN156 |
B | ILE314 |
B | ALA316 |
B | ASP396 |
B | THR399 |
B | HOH680 |
site_id | AE9 |
Number of Residues | 2 |
Details | binding site for residue FMT B 515 |
Chain | Residue |
B | ARG113 |
B | HOH616 |
site_id | AF1 |
Number of Residues | 5 |
Details | binding site for residue EDO B 516 |
Chain | Residue |
B | LYS402 |
B | GLY408 |
B | HOH664 |
H | TRP403 |
H | MLI530 |
site_id | AF2 |
Number of Residues | 2 |
Details | binding site for residue FMT B 517 |
Chain | Residue |
B | ARG265 |
B | HOH748 |
site_id | AF3 |
Number of Residues | 5 |
Details | binding site for residue FMT B 518 |
Chain | Residue |
B | ARG265 |
B | LEU266 |
B | ARG335 |
B | ASP337 |
B | FMT512 |
site_id | AF4 |
Number of Residues | 2 |
Details | binding site for residue FMT B 519 |
Chain | Residue |
B | PRO262 |
B | ARG265 |
site_id | AF5 |
Number of Residues | 7 |
Details | binding site for residue FMT B 520 |
Chain | Residue |
B | ALA287 |
B | GLY288 |
B | SER289 |
B | LEU300 |
B | LEU301 |
B | GLN302 |
B | HOH755 |
site_id | AF6 |
Number of Residues | 1 |
Details | binding site for residue FMT B 521 |
Chain | Residue |
B | ASN194 |
site_id | AF7 |
Number of Residues | 3 |
Details | binding site for residue FMT B 522 |
Chain | Residue |
B | ARG60 |
D | HOH717 |
H | ASN64 |
site_id | AF8 |
Number of Residues | 4 |
Details | binding site for residue FMT B 523 |
Chain | Residue |
B | GLN80 |
B | HOH744 |
F | ARG119 |
F | ACT808 |
site_id | AF9 |
Number of Residues | 1 |
Details | binding site for residue FMT B 524 |
Chain | Residue |
B | ASP53 |
site_id | AG1 |
Number of Residues | 7 |
Details | binding site for residue K B 525 |
Chain | Residue |
B | GLY246 |
B | ALA282 |
B | THR284 |
B | TYR320 |
B | GLY322 |
B | HOH651 |
B | HOH732 |
site_id | AG2 |
Number of Residues | 3 |
Details | binding site for residue EDO B 526 |
Chain | Residue |
B | ASP274 |
B | THR342 |
B | HOH733 |
site_id | AG3 |
Number of Residues | 9 |
Details | binding site for residue EPE B 527 |
Chain | Residue |
B | LEU61 |
B | ARG113 |
B | LEU139 |
B | HOH604 |
B | HOH605 |
D | TYR73 |
D | HOH703 |
F | GLY232 |
F | GLY235 |
site_id | AG4 |
Number of Residues | 3 |
Details | binding site for residue FMT B 528 |
Chain | Residue |
B | LEU165 |
D | GLY351 |
D | ARG355 |
site_id | AG5 |
Number of Residues | 5 |
Details | binding site for residue EDO B 529 |
Chain | Residue |
B | ARG355 |
D | ALA138 |
D | LEU166 |
D | K518 |
D | FMT521 |
site_id | AG6 |
Number of Residues | 8 |
Details | binding site for residue EPE B 530 |
Chain | Residue |
B | GLY351 |
B | ARG355 |
B | PHE404 |
B | LEU406 |
D | ARG164 |
D | LEU165 |
D | ALA168 |
H | ARG355 |
site_id | AG7 |
Number of Residues | 5 |
Details | binding site for residue FMT B 531 |
Chain | Residue |
B | PRO71 |
B | GLN229 |
D | FMT502 |
D | HOH651 |
H | ALA4 |
site_id | AG8 |
Number of Residues | 6 |
Details | binding site for residue EDO C 301 |
Chain | Residue |
C | GLY116 |
C | VAL117 |
C | ASP118 |
C | ALA119 |
C | HOH469 |
C | HOH482 |
site_id | AG9 |
Number of Residues | 4 |
Details | binding site for residue FMT C 302 |
Chain | Residue |
C | PRO162 |
C | ALA198 |
C | LEU202 |
C | ARG205 |
site_id | AH1 |
Number of Residues | 7 |
Details | binding site for residue EDO C 303 |
Chain | Residue |
C | TYR30 |
C | VAL60 |
C | ASP68 |
C | MET106 |
C | TYR108 |
C | K308 |
C | HOH433 |
site_id | AH2 |
Number of Residues | 2 |
Details | binding site for residue FMT C 304 |
Chain | Residue |
C | LYS207 |
C | ALA208 |
site_id | AH3 |
Number of Residues | 2 |
Details | binding site for residue FMT C 305 |
Chain | Residue |
C | GLU151 |
C | HIS152 |
site_id | AH4 |
Number of Residues | 8 |
Details | binding site for residue EDO C 306 |
Chain | Residue |
C | TYR30 |
C | GLU57 |
C | ILE72 |
C | MET106 |
C | TYR181 |
C | ILE237 |
C | MLI307 |
C | K308 |
site_id | AH5 |
Number of Residues | 9 |
Details | binding site for residue MLI C 307 |
Chain | Residue |
C | TYR181 |
C | GLY217 |
C | LEU218 |
C | GLY219 |
C | ILE237 |
C | GLY239 |
C | SER240 |
C | EDO306 |
C | HOH435 |
site_id | AH6 |
Number of Residues | 5 |
Details | binding site for residue K C 308 |
Chain | Residue |
C | ASP68 |
C | MET106 |
C | EDO303 |
C | EDO306 |
C | HOH498 |
site_id | AH7 |
Number of Residues | 6 |
Details | binding site for residue FMT C 309 |
Chain | Residue |
C | ILE138 |
C | PRO139 |
C | LEU159 |
C | THR172 |
C | HOH419 |
D | GLU32 |
site_id | AH8 |
Number of Residues | 17 |
Details | binding site for residue PZV D 501 |
Chain | Residue |
C | TYR62 |
C | ASP64 |
C | GLY66 |
C | MET67 |
C | TYR108 |
C | ASP136 |
D | TYR29 |
D | VAL30 |
D | ILE184 |
D | PHE188 |
D | TRP191 |
D | TYR200 |
D | PHE202 |
D | GLY207 |
D | PRO208 |
D | HIS294 |
D | GLY295 |
site_id | AH9 |
Number of Residues | 5 |
Details | binding site for residue FMT D 502 |
Chain | Residue |
B | PRO69 |
B | PRO71 |
B | FMT531 |
D | ALA63 |
D | ARG68 |
site_id | AI1 |
Number of Residues | 4 |
Details | binding site for residue FMT D 503 |
Chain | Residue |
B | LEU166 |
B | GLY167 |
B | HOH692 |
D | ARG355 |
site_id | AI2 |
Number of Residues | 4 |
Details | binding site for residue FMT D 504 |
Chain | Residue |
C | HOH468 |
D | GLU186 |
D | ARG189 |
D | HOH763 |
site_id | AI3 |
Number of Residues | 22 |
Details | binding site for residue P1T D 505 |
Chain | Residue |
D | HIS100 |
D | LYS101 |
D | THR124 |
D | GLY125 |
D | ALA126 |
D | GLY127 |
D | GLN128 |
D | HIS129 |
D | THR204 |
D | CYS244 |
D | GLY246 |
D | GLY247 |
D | GLY248 |
D | SER249 |
D | ASN250 |
D | GLY317 |
D | LEU318 |
D | GLU364 |
D | SER390 |
D | GLY391 |
D | HOH627 |
D | HOH734 |
site_id | AI4 |
Number of Residues | 5 |
Details | binding site for residue FMT D 506 |
Chain | Residue |
D | LYS47 |
D | GLU48 |
D | ARG114 |
D | HOH698 |
D | HOH759 |
site_id | AI5 |
Number of Residues | 5 |
Details | binding site for residue FMT D 507 |
Chain | Residue |
D | HIS312 |
D | SER313 |
D | ASP319 |
D | FMT515 |
D | HOH720 |
site_id | AI6 |
Number of Residues | 1 |
Details | binding site for residue FMT D 508 |
Chain | Residue |
D | TRP403 |
site_id | AI7 |
Number of Residues | 3 |
Details | binding site for residue FMT D 510 |
Chain | Residue |
D | ASP337 |
D | ARG339 |
D | GLU378 |
site_id | AI8 |
Number of Residues | 1 |
Details | binding site for residue EDO D 511 |
Chain | Residue |
D | GLY21 |
site_id | AI9 |
Number of Residues | 6 |
Details | binding site for residue FMT D 512 |
Chain | Residue |
B | GLY358 |
D | HIS96 |
D | THR135 |
D | ARG162 |
D | LEU166 |
D | HOH739 |
site_id | AJ1 |
Number of Residues | 4 |
Details | binding site for residue FMT D 513 |
Chain | Residue |
D | ARG236 |
D | LEU237 |
D | PRO238 |
D | HOH752 |
site_id | AJ2 |
Number of Residues | 7 |
Details | binding site for residue FMT D 515 |
Chain | Residue |
D | ASP274 |
D | ARG280 |
D | HIS312 |
D | SER313 |
D | ILE314 |
D | ASP343 |
D | FMT507 |
site_id | AJ3 |
Number of Residues | 3 |
Details | binding site for residue FMT D 516 |
Chain | Residue |
B | HOH629 |
D | ARG60 |
D | LEU140 |
site_id | AJ4 |
Number of Residues | 1 |
Details | binding site for residue FMT D 517 |
Chain | Residue |
D | GLU39 |
site_id | AJ5 |
Number of Residues | 4 |
Details | binding site for residue K D 518 |
Chain | Residue |
B | EDO529 |
D | LEU142 |
D | HOH650 |
D | HOH657 |
site_id | AJ6 |
Number of Residues | 4 |
Details | binding site for residue K D 519 |
Chain | Residue |
D | PHE293 |
D | SER296 |
D | SER298 |
D | HOH664 |
site_id | AJ7 |
Number of Residues | 3 |
Details | binding site for residue EDO D 520 |
Chain | Residue |
D | PRO262 |
D | ARG265 |
D | HOH646 |
site_id | AJ8 |
Number of Residues | 6 |
Details | binding site for residue FMT D 521 |
Chain | Residue |
B | EDO529 |
D | LEU142 |
D | ASP143 |
F | GLY141 |
F | LEU142 |
F | ASP143 |
site_id | AJ9 |
Number of Residues | 6 |
Details | binding site for residue K D 522 |
Chain | Residue |
D | HOH639 |
D | HOH666 |
D | HOH717 |
F | HOH968 |
F | HOH971 |
F | HOH991 |
site_id | AK1 |
Number of Residues | 3 |
Details | binding site for residue ALA E 301 |
Chain | Residue |
E | ALA262 |
E | GLY263 |
E | ARG265 |
site_id | AK2 |
Number of Residues | 7 |
Details | binding site for residue MLI E 302 |
Chain | Residue |
E | TYR181 |
E | GLY217 |
E | LEU218 |
E | GLY219 |
E | GLY239 |
E | SER240 |
E | HOH412 |
site_id | AK3 |
Number of Residues | 4 |
Details | binding site for residue FMT E 303 |
Chain | Residue |
E | GLY69 |
E | THR71 |
E | ILE72 |
E | SER240 |
site_id | AK4 |
Number of Residues | 5 |
Details | binding site for residue FMT E 304 |
Chain | Residue |
E | TYR30 |
E | VAL60 |
E | ASP68 |
E | TYR108 |
E | HOH450 |
site_id | AK5 |
Number of Residues | 4 |
Details | binding site for residue EDO E 305 |
Chain | Residue |
E | MET67 |
E | ASP68 |
E | MET106 |
E | TYR108 |
site_id | AK6 |
Number of Residues | 9 |
Details | binding site for residue PGE F 801 |
Chain | Residue |
D | SER79 |
D | GLN80 |
D | SER84 |
D | ARG86 |
D | GLY382 |
D | HOH601 |
F | ARG86 |
F | ARG236 |
F | GLY382 |
site_id | AK7 |
Number of Residues | 17 |
Details | binding site for residue PZV F 802 |
Chain | Residue |
E | TYR62 |
E | ASP64 |
E | GLY66 |
E | MET67 |
E | TYR108 |
E | ASP136 |
F | TYR29 |
F | VAL30 |
F | ILE184 |
F | PHE188 |
F | TRP191 |
F | TYR200 |
F | PHE202 |
F | GLY207 |
F | PRO208 |
F | HIS294 |
F | GLY295 |
site_id | AK8 |
Number of Residues | 1 |
Details | binding site for residue FMT F 803 |
Chain | Residue |
E | GLN144 |
site_id | AK9 |
Number of Residues | 6 |
Details | binding site for residue FMT F 804 |
Chain | Residue |
B | HOH620 |
F | VAL171 |
F | GLU186 |
F | HOH966 |
F | HOH1001 |
F | HOH1015 |
site_id | AL1 |
Number of Residues | 20 |
Details | binding site for residue P1T F 805 |
Chain | Residue |
F | HIS100 |
F | LYS101 |
F | THR124 |
F | GLY125 |
F | ALA126 |
F | GLY127 |
F | GLN128 |
F | HIS129 |
F | THR204 |
F | CYS244 |
F | GLY246 |
F | GLY247 |
F | GLY248 |
F | SER249 |
F | ASN250 |
F | GLY317 |
F | GLU364 |
F | SER390 |
F | HOH981 |
F | HOH999 |
site_id | AL2 |
Number of Residues | 3 |
Details | binding site for residue FMT F 806 |
Chain | Residue |
F | GLY351 |
F | ARG355 |
H | LEU165 |
site_id | AL3 |
Number of Residues | 3 |
Details | binding site for residue FMT F 807 |
Chain | Residue |
F | LYS47 |
F | GLU48 |
F | HOH1026 |
site_id | AL4 |
Number of Residues | 5 |
Details | binding site for residue ACT F 808 |
Chain | Residue |
B | FMT523 |
B | HOH622 |
F | ARG119 |
F | ASN194 |
F | ASN197 |
site_id | AL5 |
Number of Residues | 8 |
Details | binding site for residue PGE F 809 |
Chain | Residue |
F | SER15 |
F | ARG28 |
F | GLU39 |
F | THR42 |
F | ALA43 |
F | GLN46 |
F | HOH904 |
F | HOH1030 |
site_id | AL6 |
Number of Residues | 5 |
Details | binding site for residue FMT F 810 |
Chain | Residue |
F | ARG265 |
F | LEU266 |
F | ARG335 |
F | ASP337 |
F | EDO819 |
site_id | AL7 |
Number of Residues | 7 |
Details | binding site for residue FMT F 811 |
Chain | Residue |
F | PHE293 |
F | SER296 |
F | SER298 |
F | TYR299 |
F | GLY322 |
F | VAL323 |
F | HOH936 |
site_id | AL8 |
Number of Residues | 3 |
Details | binding site for residue EDO F 812 |
Chain | Residue |
F | HIS18 |
F | GLY21 |
F | GLY24 |
site_id | AL9 |
Number of Residues | 2 |
Details | binding site for residue FMT F 813 |
Chain | Residue |
F | ARG227 |
F | ALA257 |
site_id | AM1 |
Number of Residues | 2 |
Details | binding site for residue FMT F 814 |
Chain | Residue |
F | GLU345 |
F | ALA370 |
site_id | AM2 |
Number of Residues | 2 |
Details | binding site for residue FMT F 815 |
Chain | Residue |
F | HIS81 |
F | LYS374 |
site_id | AM3 |
Number of Residues | 2 |
Details | binding site for residue FMT F 816 |
Chain | Residue |
F | GLU40 |
F | ASP196 |
site_id | AM4 |
Number of Residues | 3 |
Details | binding site for residue FMT F 817 |
Chain | Residue |
E | PRO65 |
F | ARG189 |
F | HOH1039 |
site_id | AM5 |
Number of Residues | 5 |
Details | binding site for residue ACT F 818 |
Chain | Residue |
F | ILE151 |
F | HIS312 |
F | SER313 |
F | ASP319 |
F | HOH912 |
site_id | AM6 |
Number of Residues | 4 |
Details | binding site for residue EDO F 819 |
Chain | Residue |
F | PRO262 |
F | GLY334 |
F | ARG335 |
F | FMT810 |
site_id | AM7 |
Number of Residues | 4 |
Details | binding site for residue FMT F 820 |
Chain | Residue |
F | LEU237 |
F | PRO238 |
F | GLY263 |
F | HOH1040 |
site_id | AM8 |
Number of Residues | 1 |
Details | binding site for residue FMT F 821 |
Chain | Residue |
F | ARG60 |
site_id | AM9 |
Number of Residues | 1 |
Details | binding site for residue EDO F 822 |
Chain | Residue |
F | LEU158 |
site_id | AN1 |
Number of Residues | 7 |
Details | binding site for residue FMT F 823 |
Chain | Residue |
F | ALA66 |
F | GLY67 |
F | SER70 |
F | LEU94 |
F | ASN95 |
F | HOH945 |
F | HOH1044 |
site_id | AN2 |
Number of Residues | 3 |
Details | binding site for residue FMT F 824 |
Chain | Residue |
F | ASP260 |
F | HOH998 |
F | HOH1000 |
site_id | AN3 |
Number of Residues | 6 |
Details | binding site for residue NA F 825 |
Chain | Residue |
F | GLY67 |
F | PRO69 |
F | HOH945 |
F | HOH1044 |
H | GLY67 |
H | PRO69 |
site_id | AN4 |
Number of Residues | 6 |
Details | binding site for residue K F 826 |
Chain | Residue |
F | GLY246 |
F | ALA282 |
F | THR284 |
F | TYR320 |
F | GLY322 |
F | HOH978 |
site_id | AN5 |
Number of Residues | 6 |
Details | binding site for residue MLI F 827 |
Chain | Residue |
D | ARG236 |
F | SER79 |
F | GLN80 |
F | SER84 |
F | ARG381 |
F | HOH938 |
site_id | AN6 |
Number of Residues | 7 |
Details | binding site for residue FMT F 828 |
Chain | Residue |
F | HIS96 |
F | THR135 |
F | ARG162 |
H | GLY358 |
H | ILE360 |
H | FMT501 |
H | HOH602 |
site_id | AN7 |
Number of Residues | 7 |
Details | binding site for residue PEG F 829 |
Chain | Residue |
F | ARG77 |
F | ARG355 |
H | ALA138 |
H | GLY141 |
H | ASP143 |
H | LEU166 |
H | PEG513 |
site_id | AN8 |
Number of Residues | 8 |
Details | binding site for residue EPE F 830 |
Chain | Residue |
B | ARG355 |
F | ARG164 |
F | LEU165 |
F | ALA168 |
H | GLY351 |
H | ARG355 |
H | PHE404 |
H | LEU406 |
site_id | AN9 |
Number of Residues | 4 |
Details | binding site for residue FMT G 301 |
Chain | Residue |
G | GLU57 |
G | TYR181 |
G | ILE237 |
G | MLI311 |
site_id | AO1 |
Number of Residues | 3 |
Details | binding site for residue FMT G 302 |
Chain | Residue |
G | PRO39 |
G | VAL42 |
G | HOH495 |
site_id | AO2 |
Number of Residues | 3 |
Details | binding site for residue FMT G 303 |
Chain | Residue |
G | ARG74 |
G | HOH429 |
G | HOH438 |
site_id | AO3 |
Number of Residues | 4 |
Details | binding site for residue FMT G 304 |
Chain | Residue |
G | GLU77 |
G | LEU80 |
G | ARG81 |
G | HOH466 |
site_id | AO4 |
Number of Residues | 1 |
Details | binding site for residue FMT G 305 |
Chain | Residue |
G | ASP211 |
site_id | AO5 |
Number of Residues | 5 |
Details | binding site for residue FMT G 306 |
Chain | Residue |
G | GLY69 |
G | PRO70 |
G | THR71 |
G | ILE72 |
G | SER240 |
site_id | AO6 |
Number of Residues | 3 |
Details | binding site for residue FMT G 307 |
Chain | Residue |
G | SER163 |
H | ALA33 |
H | VAL192 |
site_id | AO7 |
Number of Residues | 2 |
Details | binding site for residue FMT G 308 |
Chain | Residue |
G | LEU146 |
G | HOH471 |
site_id | AO8 |
Number of Residues | 4 |
Details | binding site for residue PEG G 309 |
Chain | Residue |
G | ALA91 |
G | GLU94 |
G | ALA95 |
G | ILE98 |
site_id | AO9 |
Number of Residues | 4 |
Details | binding site for residue EDO G 310 |
Chain | Residue |
C | ARG85 |
C | ARG87 |
G | ARG122 |
G | HOH433 |
site_id | AP1 |
Number of Residues | 9 |
Details | binding site for residue MLI G 311 |
Chain | Residue |
G | TYR181 |
G | GLY217 |
G | LEU218 |
G | GLY219 |
G | GLY239 |
G | SER240 |
G | FMT301 |
G | HOH405 |
G | HOH430 |
site_id | AP2 |
Number of Residues | 7 |
Details | binding site for residue EDO G 312 |
Chain | Residue |
G | TYR30 |
G | VAL60 |
G | TYR62 |
G | PRO65 |
G | ASP68 |
G | THR76 |
G | TYR108 |
site_id | AP3 |
Number of Residues | 4 |
Details | binding site for residue K G 313 |
Chain | Residue |
C | HOH403 |
C | HOH475 |
G | GLU94 |
G | ALA126 |
site_id | AP4 |
Number of Residues | 8 |
Details | binding site for residue FMT H 501 |
Chain | Residue |
F | HIS96 |
F | FMT828 |
H | ASP93 |
H | LEU94 |
H | ILE360 |
H | ARG392 |
H | HOH602 |
H | HOH696 |
site_id | AP5 |
Number of Residues | 16 |
Details | binding site for residue PZV H 502 |
Chain | Residue |
G | TYR62 |
G | ASP64 |
G | GLY66 |
G | MET67 |
G | TYR108 |
G | ASP136 |
H | TYR29 |
H | VAL30 |
H | ILE184 |
H | PHE188 |
H | TRP191 |
H | TYR200 |
H | PHE202 |
H | PRO208 |
H | HIS294 |
H | GLY295 |
site_id | AP6 |
Number of Residues | 2 |
Details | binding site for residue FMT H 503 |
Chain | Residue |
H | ASP53 |
H | HOH656 |
site_id | AP7 |
Number of Residues | 19 |
Details | binding site for residue P1T H 504 |
Chain | Residue |
H | HIS100 |
H | LYS101 |
H | THR124 |
H | GLY125 |
H | ALA126 |
H | GLY127 |
H | GLN128 |
H | HIS129 |
H | THR204 |
H | GLY246 |
H | GLY247 |
H | GLY248 |
H | SER249 |
H | ASN250 |
H | GLY317 |
H | GLU364 |
H | SER390 |
H | HOH681 |
H | HOH690 |
site_id | AP8 |
Number of Residues | 4 |
Details | binding site for residue EDO H 505 |
Chain | Residue |
H | LYS47 |
H | GLU48 |
H | HOH658 |
H | HOH713 |
site_id | AP9 |
Number of Residues | 3 |
Details | binding site for residue ACT H 506 |
Chain | Residue |
G | GLN144 |
H | SER23 |
H | PHE297 |
site_id | AQ1 |
Number of Residues | 4 |
Details | binding site for residue FMT H 507 |
Chain | Residue |
G | SER63 |
H | LYS181 |
H | THR308 |
H | GLU310 |
site_id | AQ2 |
Number of Residues | 7 |
Details | binding site for residue FMT H 508 |
Chain | Residue |
H | GLN156 |
H | ILE314 |
H | SER315 |
H | ALA316 |
H | GLU364 |
H | LYS395 |
H | ASP396 |
site_id | AQ3 |
Number of Residues | 1 |
Details | binding site for residue FMT H 509 |
Chain | Residue |
H | ASN194 |
site_id | AQ4 |
Number of Residues | 2 |
Details | binding site for residue FMT H 510 |
Chain | Residue |
H | VAL173 |
H | GLN174 |
site_id | AQ5 |
Number of Residues | 3 |
Details | binding site for residue FMT H 511 |
Chain | Residue |
H | ARG113 |
H | LYS117 |
H | LEU142 |
site_id | AQ6 |
Number of Residues | 3 |
Details | binding site for residue EDO H 512 |
Chain | Residue |
G | ARG85 |
H | ASP303 |
H | ASP305 |
site_id | AQ7 |
Number of Residues | 11 |
Details | binding site for residue PEG H 513 |
Chain | Residue |
F | PEG829 |
H | ALA134 |
H | CYS137 |
H | ALA138 |
H | LEU142 |
H | ASP143 |
H | CYS144 |
H | LEU166 |
H | GLY167 |
H | ALA168 |
H | HOH607 |
site_id | AQ8 |
Number of Residues | 5 |
Details | binding site for residue FMT H 514 |
Chain | Residue |
H | ASP274 |
H | ARG280 |
H | HIS312 |
H | SER313 |
H | ASP343 |
site_id | AQ9 |
Number of Residues | 6 |
Details | binding site for residue FMT H 515 |
Chain | Residue |
F | ASP93 |
F | LEU94 |
H | HIS96 |
H | THR97 |
H | ARG392 |
H | HOH709 |
site_id | AR1 |
Number of Residues | 4 |
Details | binding site for residue FMT H 516 |
Chain | Residue |
E | ARG223 |
H | ALA333 |
H | GLY334 |
H | HOH736 |
site_id | AR2 |
Number of Residues | 3 |
Details | binding site for residue FMT H 517 |
Chain | Residue |
H | ARG164 |
H | ALA168 |
H | HOH628 |
site_id | AR3 |
Number of Residues | 2 |
Details | binding site for residue FMT H 518 |
Chain | Residue |
H | GLU74 |
H | GLN233 |
site_id | AR4 |
Number of Residues | 5 |
Details | binding site for residue FMT H 519 |
Chain | Residue |
H | PHE269 |
H | ARG339 |
H | GLY371 |
H | GLU378 |
H | FMT522 |
site_id | AR5 |
Number of Residues | 6 |
Details | binding site for residue EDO H 520 |
Chain | Residue |
H | GLY273 |
H | ASP274 |
H | THR342 |
H | ASP343 |
H | SER344 |
H | FMT524 |
site_id | AR6 |
Number of Residues | 1 |
Details | binding site for residue EDO H 521 |
Chain | Residue |
H | ARG335 |
site_id | AR7 |
Number of Residues | 4 |
Details | binding site for residue FMT H 522 |
Chain | Residue |
H | ARG339 |
H | PRO340 |
H | LYS374 |
H | FMT519 |
site_id | AR8 |
Number of Residues | 4 |
Details | binding site for residue FMT H 523 |
Chain | Residue |
H | ARG236 |
H | LEU237 |
H | PRO238 |
H | GLY263 |
site_id | AR9 |
Number of Residues | 4 |
Details | binding site for residue FMT H 524 |
Chain | Residue |
H | ASP274 |
H | GLY275 |
H | THR342 |
H | EDO520 |
site_id | AS1 |
Number of Residues | 4 |
Details | binding site for residue FMT H 525 |
Chain | Residue |
H | ARG265 |
H | LEU266 |
H | ARG335 |
H | ASP337 |
site_id | AS2 |
Number of Residues | 4 |
Details | binding site for residue FMT H 526 |
Chain | Residue |
H | LYS331 |
H | ASP337 |
H | TYR338 |
H | FMT528 |
site_id | AS3 |
Number of Residues | 1 |
Details | binding site for residue FMT H 527 |
Chain | Residue |
H | SER23 |
site_id | AS4 |
Number of Residues | 3 |
Details | binding site for residue FMT H 528 |
Chain | Residue |
H | TYR338 |
H | ARG339 |
H | FMT526 |
site_id | AS5 |
Number of Residues | 3 |
Details | binding site for residue FMT H 529 |
Chain | Residue |
H | ALA6 |
H | ASP217 |
H | ARG220 |
site_id | AS6 |
Number of Residues | 5 |
Details | binding site for residue MLI H 530 |
Chain | Residue |
B | TRP403 |
B | EDO516 |
B | HOH664 |
H | LYS402 |
H | TRP403 |
site_id | AS7 |
Number of Residues | 6 |
Details | binding site for residue K H 531 |
Chain | Residue |
H | GLY246 |
H | ALA282 |
H | THR284 |
H | TYR320 |
H | GLY322 |
H | HOH752 |
site_id | AS8 |
Number of Residues | 7 |
Details | binding site for residue EPE H 532 |
Chain | Residue |
D | GLY232 |
D | GLY235 |
F | TYR73 |
H | LEU61 |
H | ARG113 |
H | LEU139 |
H | HOH626 |
site_id | AS9 |
Number of Residues | 5 |
Details | binding site for residue EDO H 533 |
Chain | Residue |
D | ARG119 |
H | GLN80 |
H | MET356 |
H | HOH634 |
H | HOH708 |
Functional Information from PROSITE/UniProt
site_id | PS00167 |
Number of Residues | 14 |
Details | TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. IEVGvPYSDPGMDG |
Chain | Residue | Details |
A | ILE56-GLY69 |
site_id | PS00168 |
Number of Residues | 15 |
Details | TRP_SYNTHASE_BETA Tryptophan synthase beta chain pyridoxal-phosphate attachment site. LnHtGSHKiNnvLgQ |
Chain | Residue | Details |
B | LEU94-GLN108 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000255|HAMAP-Rule:MF_00133 |
Chain | Residue | Details |
B | HIS100 | |
D | HIS100 | |
F | HIS100 | |
H | HIS100 | |
E | GLU57 | |
E | ASP68 | |
G | GLU57 | |
G | ASP68 |