6U6C
Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate- and GSK2-bound form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000162 | biological_process | L-tryptophan biosynthetic process |
| A | 0004834 | molecular_function | tryptophan synthase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006568 | biological_process | L-tryptophan metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| B | 0000162 | biological_process | L-tryptophan biosynthetic process |
| B | 0004834 | molecular_function | tryptophan synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006568 | biological_process | L-tryptophan metabolic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 1901605 | biological_process | alpha-amino acid metabolic process |
| C | 0000162 | biological_process | L-tryptophan biosynthetic process |
| C | 0004834 | molecular_function | tryptophan synthase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006568 | biological_process | L-tryptophan metabolic process |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| D | 0000162 | biological_process | L-tryptophan biosynthetic process |
| D | 0004834 | molecular_function | tryptophan synthase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006568 | biological_process | L-tryptophan metabolic process |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 1901605 | biological_process | alpha-amino acid metabolic process |
| E | 0000162 | biological_process | L-tryptophan biosynthetic process |
| E | 0004834 | molecular_function | tryptophan synthase activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0006568 | biological_process | L-tryptophan metabolic process |
| E | 0008652 | biological_process | amino acid biosynthetic process |
| E | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| E | 0016829 | molecular_function | lyase activity |
| F | 0000162 | biological_process | L-tryptophan biosynthetic process |
| F | 0004834 | molecular_function | tryptophan synthase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006568 | biological_process | L-tryptophan metabolic process |
| F | 0008652 | biological_process | amino acid biosynthetic process |
| F | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| F | 0016829 | molecular_function | lyase activity |
| F | 1901605 | biological_process | alpha-amino acid metabolic process |
| G | 0000162 | biological_process | L-tryptophan biosynthetic process |
| G | 0004834 | molecular_function | tryptophan synthase activity |
| G | 0005829 | cellular_component | cytosol |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0006568 | biological_process | L-tryptophan metabolic process |
| G | 0008652 | biological_process | amino acid biosynthetic process |
| G | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| G | 0016829 | molecular_function | lyase activity |
| H | 0000162 | biological_process | L-tryptophan biosynthetic process |
| H | 0004834 | molecular_function | tryptophan synthase activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0006568 | biological_process | L-tryptophan metabolic process |
| H | 0008652 | biological_process | amino acid biosynthetic process |
| H | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| H | 0016829 | molecular_function | lyase activity |
| H | 1901605 | biological_process | alpha-amino acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue FMT A 301 |
| Chain | Residue |
| A | GLY83 |
| A | ARG85 |
| A | ASP88 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue FMT A 302 |
| Chain | Residue |
| A | GLU57 |
| A | MET106 |
| A | TYR181 |
| A | ILE237 |
| A | MLI311 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue FMT A 303 |
| Chain | Residue |
| A | GLY116 |
| A | VAL117 |
| A | GLN144 |
| A | HOH434 |
| A | LEU113 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 304 |
| Chain | Residue |
| A | TYR35 |
| A | PRO36 |
| A | HOH436 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue FMT A 305 |
| Chain | Residue |
| A | ASP140 |
| A | ALA171 |
| A | HOH464 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue FMT A 306 |
| Chain | Residue |
| A | ARG11 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue FMT A 307 |
| Chain | Residue |
| A | GLY69 |
| A | PRO70 |
| A | THR71 |
| A | HOH430 |
| A | HOH442 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue FMT A 308 |
| Chain | Residue |
| A | MET67 |
| A | MET106 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue FMT A 309 |
| Chain | Residue |
| A | TYR30 |
| A | VAL60 |
| A | ASP68 |
| A | MET106 |
| A | HOH445 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 310 |
| Chain | Residue |
| A | PRO162 |
| A | SER164 |
| A | THR165 |
| A | PRO166 |
| A | ARG205 |
| site_id | AD2 |
| Number of Residues | 10 |
| Details | binding site for residue MLI A 311 |
| Chain | Residue |
| A | TYR181 |
| A | GLY217 |
| A | LEU218 |
| A | GLY219 |
| A | GLY239 |
| A | SER240 |
| A | FMT302 |
| A | HOH401 |
| A | HOH417 |
| A | HOH426 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 312 |
| Chain | Residue |
| A | LEU113 |
| A | GLN144 |
| B | SER23 |
| B | PHE297 |
| site_id | AD4 |
| Number of Residues | 17 |
| Details | binding site for residue PZV B 501 |
| Chain | Residue |
| A | TYR62 |
| A | ASP64 |
| A | GLY66 |
| A | MET67 |
| A | TYR108 |
| A | ASP136 |
| B | TYR29 |
| B | VAL30 |
| B | ILE184 |
| B | PHE188 |
| B | TRP191 |
| B | TYR200 |
| B | PHE202 |
| B | GLY207 |
| B | PRO208 |
| B | HIS294 |
| B | GLY295 |
| site_id | AD5 |
| Number of Residues | 18 |
| Details | binding site for residue P1T B 502 |
| Chain | Residue |
| B | HIS100 |
| B | LYS101 |
| B | THR124 |
| B | GLY125 |
| B | ALA126 |
| B | GLY127 |
| B | GLN128 |
| B | HIS129 |
| B | THR204 |
| B | GLY246 |
| B | GLY247 |
| B | GLY248 |
| B | SER249 |
| B | ASN250 |
| B | GLY317 |
| B | GLU364 |
| B | SER390 |
| B | HOH640 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 503 |
| Chain | Residue |
| B | VAL171 |
| B | ALA172 |
| B | GLN174 |
| B | GLU186 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue FMT B 504 |
| Chain | Residue |
| A | THR165 |
| B | ALA36 |
| B | GLU39 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue FMT B 505 |
| Chain | Residue |
| B | HIS81 |
| B | HOH607 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue PEG B 506 |
| Chain | Residue |
| B | GLU48 |
| B | ARG114 |
| B | HOH731 |
| B | GLU40 |
| B | ALA43 |
| B | ALA44 |
| B | LYS47 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue FMT B 507 |
| Chain | Residue |
| B | HIS312 |
| B | SER313 |
| B | ASP319 |
| B | HOH706 |
| site_id | AE2 |
| Number of Residues | 2 |
| Details | binding site for residue FMT B 508 |
| Chain | Residue |
| B | ASP274 |
| B | ASP343 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 509 |
| Chain | Residue |
| B | ARG236 |
| B | LEU237 |
| B | PRO238 |
| B | ASP239 |
| B | GLY263 |
| B | HOH691 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 510 |
| Chain | Residue |
| B | ASP59 |
| B | GLN62 |
| B | ARG68 |
| B | ILE221 |
| B | GLU225 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 511 |
| Chain | Residue |
| B | GLU40 |
| B | LYS117 |
| B | ALA195 |
| B | ASP196 |
| B | HOH625 |
| site_id | AE6 |
| Number of Residues | 3 |
| Details | binding site for residue FMT B 512 |
| Chain | Residue |
| B | GLY334 |
| B | ASP337 |
| B | FMT518 |
| site_id | AE7 |
| Number of Residues | 3 |
| Details | binding site for residue FMT B 513 |
| Chain | Residue |
| B | ARG164 |
| B | ALA168 |
| B | HOH752 |
| site_id | AE8 |
| Number of Residues | 7 |
| Details | binding site for residue FMT B 514 |
| Chain | Residue |
| B | ARG155 |
| B | GLN156 |
| B | ILE314 |
| B | ALA316 |
| B | ASP396 |
| B | THR399 |
| B | HOH680 |
| site_id | AE9 |
| Number of Residues | 2 |
| Details | binding site for residue FMT B 515 |
| Chain | Residue |
| B | ARG113 |
| B | HOH616 |
| site_id | AF1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 516 |
| Chain | Residue |
| B | LYS402 |
| B | GLY408 |
| B | HOH664 |
| H | TRP403 |
| H | MLI530 |
| site_id | AF2 |
| Number of Residues | 2 |
| Details | binding site for residue FMT B 517 |
| Chain | Residue |
| B | ARG265 |
| B | HOH748 |
| site_id | AF3 |
| Number of Residues | 5 |
| Details | binding site for residue FMT B 518 |
| Chain | Residue |
| B | ARG265 |
| B | LEU266 |
| B | ARG335 |
| B | ASP337 |
| B | FMT512 |
| site_id | AF4 |
| Number of Residues | 2 |
| Details | binding site for residue FMT B 519 |
| Chain | Residue |
| B | PRO262 |
| B | ARG265 |
| site_id | AF5 |
| Number of Residues | 7 |
| Details | binding site for residue FMT B 520 |
| Chain | Residue |
| B | ALA287 |
| B | GLY288 |
| B | SER289 |
| B | LEU300 |
| B | LEU301 |
| B | GLN302 |
| B | HOH755 |
| site_id | AF6 |
| Number of Residues | 1 |
| Details | binding site for residue FMT B 521 |
| Chain | Residue |
| B | ASN194 |
| site_id | AF7 |
| Number of Residues | 3 |
| Details | binding site for residue FMT B 522 |
| Chain | Residue |
| B | ARG60 |
| D | HOH717 |
| H | ASN64 |
| site_id | AF8 |
| Number of Residues | 4 |
| Details | binding site for residue FMT B 523 |
| Chain | Residue |
| B | GLN80 |
| B | HOH744 |
| F | ARG119 |
| F | ACT808 |
| site_id | AF9 |
| Number of Residues | 1 |
| Details | binding site for residue FMT B 524 |
| Chain | Residue |
| B | ASP53 |
| site_id | AG1 |
| Number of Residues | 7 |
| Details | binding site for residue K B 525 |
| Chain | Residue |
| B | GLY246 |
| B | ALA282 |
| B | THR284 |
| B | TYR320 |
| B | GLY322 |
| B | HOH651 |
| B | HOH732 |
| site_id | AG2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 526 |
| Chain | Residue |
| B | ASP274 |
| B | THR342 |
| B | HOH733 |
| site_id | AG3 |
| Number of Residues | 9 |
| Details | binding site for residue EPE B 527 |
| Chain | Residue |
| B | LEU61 |
| B | ARG113 |
| B | LEU139 |
| B | HOH604 |
| B | HOH605 |
| D | TYR73 |
| D | HOH703 |
| F | GLY232 |
| F | GLY235 |
| site_id | AG4 |
| Number of Residues | 3 |
| Details | binding site for residue FMT B 528 |
| Chain | Residue |
| B | LEU165 |
| D | GLY351 |
| D | ARG355 |
| site_id | AG5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 529 |
| Chain | Residue |
| B | ARG355 |
| D | ALA138 |
| D | LEU166 |
| D | K518 |
| D | FMT521 |
| site_id | AG6 |
| Number of Residues | 8 |
| Details | binding site for residue EPE B 530 |
| Chain | Residue |
| B | GLY351 |
| B | ARG355 |
| B | PHE404 |
| B | LEU406 |
| D | ARG164 |
| D | LEU165 |
| D | ALA168 |
| H | ARG355 |
| site_id | AG7 |
| Number of Residues | 5 |
| Details | binding site for residue FMT B 531 |
| Chain | Residue |
| B | PRO71 |
| B | GLN229 |
| D | FMT502 |
| D | HOH651 |
| H | ALA4 |
| site_id | AG8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 301 |
| Chain | Residue |
| C | GLY116 |
| C | VAL117 |
| C | ASP118 |
| C | ALA119 |
| C | HOH469 |
| C | HOH482 |
| site_id | AG9 |
| Number of Residues | 4 |
| Details | binding site for residue FMT C 302 |
| Chain | Residue |
| C | PRO162 |
| C | ALA198 |
| C | LEU202 |
| C | ARG205 |
| site_id | AH1 |
| Number of Residues | 7 |
| Details | binding site for residue EDO C 303 |
| Chain | Residue |
| C | TYR30 |
| C | VAL60 |
| C | ASP68 |
| C | MET106 |
| C | TYR108 |
| C | K308 |
| C | HOH433 |
| site_id | AH2 |
| Number of Residues | 2 |
| Details | binding site for residue FMT C 304 |
| Chain | Residue |
| C | LYS207 |
| C | ALA208 |
| site_id | AH3 |
| Number of Residues | 2 |
| Details | binding site for residue FMT C 305 |
| Chain | Residue |
| C | GLU151 |
| C | HIS152 |
| site_id | AH4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO C 306 |
| Chain | Residue |
| C | TYR30 |
| C | GLU57 |
| C | ILE72 |
| C | MET106 |
| C | TYR181 |
| C | ILE237 |
| C | MLI307 |
| C | K308 |
| site_id | AH5 |
| Number of Residues | 9 |
| Details | binding site for residue MLI C 307 |
| Chain | Residue |
| C | TYR181 |
| C | GLY217 |
| C | LEU218 |
| C | GLY219 |
| C | ILE237 |
| C | GLY239 |
| C | SER240 |
| C | EDO306 |
| C | HOH435 |
| site_id | AH6 |
| Number of Residues | 5 |
| Details | binding site for residue K C 308 |
| Chain | Residue |
| C | ASP68 |
| C | MET106 |
| C | EDO303 |
| C | EDO306 |
| C | HOH498 |
| site_id | AH7 |
| Number of Residues | 6 |
| Details | binding site for residue FMT C 309 |
| Chain | Residue |
| C | ILE138 |
| C | PRO139 |
| C | LEU159 |
| C | THR172 |
| C | HOH419 |
| D | GLU32 |
| site_id | AH8 |
| Number of Residues | 17 |
| Details | binding site for residue PZV D 501 |
| Chain | Residue |
| C | TYR62 |
| C | ASP64 |
| C | GLY66 |
| C | MET67 |
| C | TYR108 |
| C | ASP136 |
| D | TYR29 |
| D | VAL30 |
| D | ILE184 |
| D | PHE188 |
| D | TRP191 |
| D | TYR200 |
| D | PHE202 |
| D | GLY207 |
| D | PRO208 |
| D | HIS294 |
| D | GLY295 |
| site_id | AH9 |
| Number of Residues | 5 |
| Details | binding site for residue FMT D 502 |
| Chain | Residue |
| B | PRO69 |
| B | PRO71 |
| B | FMT531 |
| D | ALA63 |
| D | ARG68 |
| site_id | AI1 |
| Number of Residues | 4 |
| Details | binding site for residue FMT D 503 |
| Chain | Residue |
| B | LEU166 |
| B | GLY167 |
| B | HOH692 |
| D | ARG355 |
| site_id | AI2 |
| Number of Residues | 4 |
| Details | binding site for residue FMT D 504 |
| Chain | Residue |
| C | HOH468 |
| D | GLU186 |
| D | ARG189 |
| D | HOH763 |
| site_id | AI3 |
| Number of Residues | 22 |
| Details | binding site for residue P1T D 505 |
| Chain | Residue |
| D | HIS100 |
| D | LYS101 |
| D | THR124 |
| D | GLY125 |
| D | ALA126 |
| D | GLY127 |
| D | GLN128 |
| D | HIS129 |
| D | THR204 |
| D | CYS244 |
| D | GLY246 |
| D | GLY247 |
| D | GLY248 |
| D | SER249 |
| D | ASN250 |
| D | GLY317 |
| D | LEU318 |
| D | GLU364 |
| D | SER390 |
| D | GLY391 |
| D | HOH627 |
| D | HOH734 |
| site_id | AI4 |
| Number of Residues | 5 |
| Details | binding site for residue FMT D 506 |
| Chain | Residue |
| D | LYS47 |
| D | GLU48 |
| D | ARG114 |
| D | HOH698 |
| D | HOH759 |
| site_id | AI5 |
| Number of Residues | 5 |
| Details | binding site for residue FMT D 507 |
| Chain | Residue |
| D | HIS312 |
| D | SER313 |
| D | ASP319 |
| D | FMT515 |
| D | HOH720 |
| site_id | AI6 |
| Number of Residues | 1 |
| Details | binding site for residue FMT D 508 |
| Chain | Residue |
| D | TRP403 |
| site_id | AI7 |
| Number of Residues | 3 |
| Details | binding site for residue FMT D 510 |
| Chain | Residue |
| D | ASP337 |
| D | ARG339 |
| D | GLU378 |
| site_id | AI8 |
| Number of Residues | 1 |
| Details | binding site for residue EDO D 511 |
| Chain | Residue |
| D | GLY21 |
| site_id | AI9 |
| Number of Residues | 6 |
| Details | binding site for residue FMT D 512 |
| Chain | Residue |
| B | GLY358 |
| D | HIS96 |
| D | THR135 |
| D | ARG162 |
| D | LEU166 |
| D | HOH739 |
| site_id | AJ1 |
| Number of Residues | 4 |
| Details | binding site for residue FMT D 513 |
| Chain | Residue |
| D | ARG236 |
| D | LEU237 |
| D | PRO238 |
| D | HOH752 |
| site_id | AJ2 |
| Number of Residues | 7 |
| Details | binding site for residue FMT D 515 |
| Chain | Residue |
| D | ASP274 |
| D | ARG280 |
| D | HIS312 |
| D | SER313 |
| D | ILE314 |
| D | ASP343 |
| D | FMT507 |
| site_id | AJ3 |
| Number of Residues | 3 |
| Details | binding site for residue FMT D 516 |
| Chain | Residue |
| B | HOH629 |
| D | ARG60 |
| D | LEU140 |
| site_id | AJ4 |
| Number of Residues | 1 |
| Details | binding site for residue FMT D 517 |
| Chain | Residue |
| D | GLU39 |
| site_id | AJ5 |
| Number of Residues | 4 |
| Details | binding site for residue K D 518 |
| Chain | Residue |
| B | EDO529 |
| D | LEU142 |
| D | HOH650 |
| D | HOH657 |
| site_id | AJ6 |
| Number of Residues | 4 |
| Details | binding site for residue K D 519 |
| Chain | Residue |
| D | PHE293 |
| D | SER296 |
| D | SER298 |
| D | HOH664 |
| site_id | AJ7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 520 |
| Chain | Residue |
| D | PRO262 |
| D | ARG265 |
| D | HOH646 |
| site_id | AJ8 |
| Number of Residues | 6 |
| Details | binding site for residue FMT D 521 |
| Chain | Residue |
| B | EDO529 |
| D | LEU142 |
| D | ASP143 |
| F | GLY141 |
| F | LEU142 |
| F | ASP143 |
| site_id | AJ9 |
| Number of Residues | 6 |
| Details | binding site for residue K D 522 |
| Chain | Residue |
| D | HOH639 |
| D | HOH666 |
| D | HOH717 |
| F | HOH968 |
| F | HOH971 |
| F | HOH991 |
| site_id | AK1 |
| Number of Residues | 3 |
| Details | binding site for residue ALA E 301 |
| Chain | Residue |
| E | ALA262 |
| E | GLY263 |
| E | ARG265 |
| site_id | AK2 |
| Number of Residues | 7 |
| Details | binding site for residue MLI E 302 |
| Chain | Residue |
| E | TYR181 |
| E | GLY217 |
| E | LEU218 |
| E | GLY219 |
| E | GLY239 |
| E | SER240 |
| E | HOH412 |
| site_id | AK3 |
| Number of Residues | 4 |
| Details | binding site for residue FMT E 303 |
| Chain | Residue |
| E | GLY69 |
| E | THR71 |
| E | ILE72 |
| E | SER240 |
| site_id | AK4 |
| Number of Residues | 5 |
| Details | binding site for residue FMT E 304 |
| Chain | Residue |
| E | TYR30 |
| E | VAL60 |
| E | ASP68 |
| E | TYR108 |
| E | HOH450 |
| site_id | AK5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO E 305 |
| Chain | Residue |
| E | MET67 |
| E | ASP68 |
| E | MET106 |
| E | TYR108 |
| site_id | AK6 |
| Number of Residues | 9 |
| Details | binding site for residue PGE F 801 |
| Chain | Residue |
| D | SER79 |
| D | GLN80 |
| D | SER84 |
| D | ARG86 |
| D | GLY382 |
| D | HOH601 |
| F | ARG86 |
| F | ARG236 |
| F | GLY382 |
| site_id | AK7 |
| Number of Residues | 17 |
| Details | binding site for residue PZV F 802 |
| Chain | Residue |
| E | TYR62 |
| E | ASP64 |
| E | GLY66 |
| E | MET67 |
| E | TYR108 |
| E | ASP136 |
| F | TYR29 |
| F | VAL30 |
| F | ILE184 |
| F | PHE188 |
| F | TRP191 |
| F | TYR200 |
| F | PHE202 |
| F | GLY207 |
| F | PRO208 |
| F | HIS294 |
| F | GLY295 |
| site_id | AK8 |
| Number of Residues | 1 |
| Details | binding site for residue FMT F 803 |
| Chain | Residue |
| E | GLN144 |
| site_id | AK9 |
| Number of Residues | 6 |
| Details | binding site for residue FMT F 804 |
| Chain | Residue |
| B | HOH620 |
| F | VAL171 |
| F | GLU186 |
| F | HOH966 |
| F | HOH1001 |
| F | HOH1015 |
| site_id | AL1 |
| Number of Residues | 20 |
| Details | binding site for residue P1T F 805 |
| Chain | Residue |
| F | HIS100 |
| F | LYS101 |
| F | THR124 |
| F | GLY125 |
| F | ALA126 |
| F | GLY127 |
| F | GLN128 |
| F | HIS129 |
| F | THR204 |
| F | CYS244 |
| F | GLY246 |
| F | GLY247 |
| F | GLY248 |
| F | SER249 |
| F | ASN250 |
| F | GLY317 |
| F | GLU364 |
| F | SER390 |
| F | HOH981 |
| F | HOH999 |
| site_id | AL2 |
| Number of Residues | 3 |
| Details | binding site for residue FMT F 806 |
| Chain | Residue |
| F | GLY351 |
| F | ARG355 |
| H | LEU165 |
| site_id | AL3 |
| Number of Residues | 3 |
| Details | binding site for residue FMT F 807 |
| Chain | Residue |
| F | LYS47 |
| F | GLU48 |
| F | HOH1026 |
| site_id | AL4 |
| Number of Residues | 5 |
| Details | binding site for residue ACT F 808 |
| Chain | Residue |
| B | FMT523 |
| B | HOH622 |
| F | ARG119 |
| F | ASN194 |
| F | ASN197 |
| site_id | AL5 |
| Number of Residues | 8 |
| Details | binding site for residue PGE F 809 |
| Chain | Residue |
| F | SER15 |
| F | ARG28 |
| F | GLU39 |
| F | THR42 |
| F | ALA43 |
| F | GLN46 |
| F | HOH904 |
| F | HOH1030 |
| site_id | AL6 |
| Number of Residues | 5 |
| Details | binding site for residue FMT F 810 |
| Chain | Residue |
| F | ARG265 |
| F | LEU266 |
| F | ARG335 |
| F | ASP337 |
| F | EDO819 |
| site_id | AL7 |
| Number of Residues | 7 |
| Details | binding site for residue FMT F 811 |
| Chain | Residue |
| F | PHE293 |
| F | SER296 |
| F | SER298 |
| F | TYR299 |
| F | GLY322 |
| F | VAL323 |
| F | HOH936 |
| site_id | AL8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO F 812 |
| Chain | Residue |
| F | HIS18 |
| F | GLY21 |
| F | GLY24 |
| site_id | AL9 |
| Number of Residues | 2 |
| Details | binding site for residue FMT F 813 |
| Chain | Residue |
| F | ARG227 |
| F | ALA257 |
| site_id | AM1 |
| Number of Residues | 2 |
| Details | binding site for residue FMT F 814 |
| Chain | Residue |
| F | GLU345 |
| F | ALA370 |
| site_id | AM2 |
| Number of Residues | 2 |
| Details | binding site for residue FMT F 815 |
| Chain | Residue |
| F | HIS81 |
| F | LYS374 |
| site_id | AM3 |
| Number of Residues | 2 |
| Details | binding site for residue FMT F 816 |
| Chain | Residue |
| F | GLU40 |
| F | ASP196 |
| site_id | AM4 |
| Number of Residues | 3 |
| Details | binding site for residue FMT F 817 |
| Chain | Residue |
| E | PRO65 |
| F | ARG189 |
| F | HOH1039 |
| site_id | AM5 |
| Number of Residues | 5 |
| Details | binding site for residue ACT F 818 |
| Chain | Residue |
| F | ILE151 |
| F | HIS312 |
| F | SER313 |
| F | ASP319 |
| F | HOH912 |
| site_id | AM6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO F 819 |
| Chain | Residue |
| F | PRO262 |
| F | GLY334 |
| F | ARG335 |
| F | FMT810 |
| site_id | AM7 |
| Number of Residues | 4 |
| Details | binding site for residue FMT F 820 |
| Chain | Residue |
| F | LEU237 |
| F | PRO238 |
| F | GLY263 |
| F | HOH1040 |
| site_id | AM8 |
| Number of Residues | 1 |
| Details | binding site for residue FMT F 821 |
| Chain | Residue |
| F | ARG60 |
| site_id | AM9 |
| Number of Residues | 1 |
| Details | binding site for residue EDO F 822 |
| Chain | Residue |
| F | LEU158 |
| site_id | AN1 |
| Number of Residues | 7 |
| Details | binding site for residue FMT F 823 |
| Chain | Residue |
| F | ALA66 |
| F | GLY67 |
| F | SER70 |
| F | LEU94 |
| F | ASN95 |
| F | HOH945 |
| F | HOH1044 |
| site_id | AN2 |
| Number of Residues | 3 |
| Details | binding site for residue FMT F 824 |
| Chain | Residue |
| F | ASP260 |
| F | HOH998 |
| F | HOH1000 |
| site_id | AN3 |
| Number of Residues | 6 |
| Details | binding site for residue NA F 825 |
| Chain | Residue |
| F | GLY67 |
| F | PRO69 |
| F | HOH945 |
| F | HOH1044 |
| H | GLY67 |
| H | PRO69 |
| site_id | AN4 |
| Number of Residues | 6 |
| Details | binding site for residue K F 826 |
| Chain | Residue |
| F | GLY246 |
| F | ALA282 |
| F | THR284 |
| F | TYR320 |
| F | GLY322 |
| F | HOH978 |
| site_id | AN5 |
| Number of Residues | 6 |
| Details | binding site for residue MLI F 827 |
| Chain | Residue |
| D | ARG236 |
| F | SER79 |
| F | GLN80 |
| F | SER84 |
| F | ARG381 |
| F | HOH938 |
| site_id | AN6 |
| Number of Residues | 7 |
| Details | binding site for residue FMT F 828 |
| Chain | Residue |
| F | HIS96 |
| F | THR135 |
| F | ARG162 |
| H | GLY358 |
| H | ILE360 |
| H | FMT501 |
| H | HOH602 |
| site_id | AN7 |
| Number of Residues | 7 |
| Details | binding site for residue PEG F 829 |
| Chain | Residue |
| F | ARG77 |
| F | ARG355 |
| H | ALA138 |
| H | GLY141 |
| H | ASP143 |
| H | LEU166 |
| H | PEG513 |
| site_id | AN8 |
| Number of Residues | 8 |
| Details | binding site for residue EPE F 830 |
| Chain | Residue |
| B | ARG355 |
| F | ARG164 |
| F | LEU165 |
| F | ALA168 |
| H | GLY351 |
| H | ARG355 |
| H | PHE404 |
| H | LEU406 |
| site_id | AN9 |
| Number of Residues | 4 |
| Details | binding site for residue FMT G 301 |
| Chain | Residue |
| G | GLU57 |
| G | TYR181 |
| G | ILE237 |
| G | MLI311 |
| site_id | AO1 |
| Number of Residues | 3 |
| Details | binding site for residue FMT G 302 |
| Chain | Residue |
| G | PRO39 |
| G | VAL42 |
| G | HOH495 |
| site_id | AO2 |
| Number of Residues | 3 |
| Details | binding site for residue FMT G 303 |
| Chain | Residue |
| G | ARG74 |
| G | HOH429 |
| G | HOH438 |
| site_id | AO3 |
| Number of Residues | 4 |
| Details | binding site for residue FMT G 304 |
| Chain | Residue |
| G | GLU77 |
| G | LEU80 |
| G | ARG81 |
| G | HOH466 |
| site_id | AO4 |
| Number of Residues | 1 |
| Details | binding site for residue FMT G 305 |
| Chain | Residue |
| G | ASP211 |
| site_id | AO5 |
| Number of Residues | 5 |
| Details | binding site for residue FMT G 306 |
| Chain | Residue |
| G | GLY69 |
| G | PRO70 |
| G | THR71 |
| G | ILE72 |
| G | SER240 |
| site_id | AO6 |
| Number of Residues | 3 |
| Details | binding site for residue FMT G 307 |
| Chain | Residue |
| G | SER163 |
| H | ALA33 |
| H | VAL192 |
| site_id | AO7 |
| Number of Residues | 2 |
| Details | binding site for residue FMT G 308 |
| Chain | Residue |
| G | LEU146 |
| G | HOH471 |
| site_id | AO8 |
| Number of Residues | 4 |
| Details | binding site for residue PEG G 309 |
| Chain | Residue |
| G | ALA91 |
| G | GLU94 |
| G | ALA95 |
| G | ILE98 |
| site_id | AO9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO G 310 |
| Chain | Residue |
| C | ARG85 |
| C | ARG87 |
| G | ARG122 |
| G | HOH433 |
| site_id | AP1 |
| Number of Residues | 9 |
| Details | binding site for residue MLI G 311 |
| Chain | Residue |
| G | TYR181 |
| G | GLY217 |
| G | LEU218 |
| G | GLY219 |
| G | GLY239 |
| G | SER240 |
| G | FMT301 |
| G | HOH405 |
| G | HOH430 |
| site_id | AP2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO G 312 |
| Chain | Residue |
| G | TYR30 |
| G | VAL60 |
| G | TYR62 |
| G | PRO65 |
| G | ASP68 |
| G | THR76 |
| G | TYR108 |
| site_id | AP3 |
| Number of Residues | 4 |
| Details | binding site for residue K G 313 |
| Chain | Residue |
| C | HOH403 |
| C | HOH475 |
| G | GLU94 |
| G | ALA126 |
| site_id | AP4 |
| Number of Residues | 8 |
| Details | binding site for residue FMT H 501 |
| Chain | Residue |
| F | HIS96 |
| F | FMT828 |
| H | ASP93 |
| H | LEU94 |
| H | ILE360 |
| H | ARG392 |
| H | HOH602 |
| H | HOH696 |
| site_id | AP5 |
| Number of Residues | 16 |
| Details | binding site for residue PZV H 502 |
| Chain | Residue |
| G | TYR62 |
| G | ASP64 |
| G | GLY66 |
| G | MET67 |
| G | TYR108 |
| G | ASP136 |
| H | TYR29 |
| H | VAL30 |
| H | ILE184 |
| H | PHE188 |
| H | TRP191 |
| H | TYR200 |
| H | PHE202 |
| H | PRO208 |
| H | HIS294 |
| H | GLY295 |
| site_id | AP6 |
| Number of Residues | 2 |
| Details | binding site for residue FMT H 503 |
| Chain | Residue |
| H | ASP53 |
| H | HOH656 |
| site_id | AP7 |
| Number of Residues | 19 |
| Details | binding site for residue P1T H 504 |
| Chain | Residue |
| H | HIS100 |
| H | LYS101 |
| H | THR124 |
| H | GLY125 |
| H | ALA126 |
| H | GLY127 |
| H | GLN128 |
| H | HIS129 |
| H | THR204 |
| H | GLY246 |
| H | GLY247 |
| H | GLY248 |
| H | SER249 |
| H | ASN250 |
| H | GLY317 |
| H | GLU364 |
| H | SER390 |
| H | HOH681 |
| H | HOH690 |
| site_id | AP8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO H 505 |
| Chain | Residue |
| H | LYS47 |
| H | GLU48 |
| H | HOH658 |
| H | HOH713 |
| site_id | AP9 |
| Number of Residues | 3 |
| Details | binding site for residue ACT H 506 |
| Chain | Residue |
| G | GLN144 |
| H | SER23 |
| H | PHE297 |
| site_id | AQ1 |
| Number of Residues | 4 |
| Details | binding site for residue FMT H 507 |
| Chain | Residue |
| G | SER63 |
| H | LYS181 |
| H | THR308 |
| H | GLU310 |
| site_id | AQ2 |
| Number of Residues | 7 |
| Details | binding site for residue FMT H 508 |
| Chain | Residue |
| H | GLN156 |
| H | ILE314 |
| H | SER315 |
| H | ALA316 |
| H | GLU364 |
| H | LYS395 |
| H | ASP396 |
| site_id | AQ3 |
| Number of Residues | 1 |
| Details | binding site for residue FMT H 509 |
| Chain | Residue |
| H | ASN194 |
| site_id | AQ4 |
| Number of Residues | 2 |
| Details | binding site for residue FMT H 510 |
| Chain | Residue |
| H | VAL173 |
| H | GLN174 |
| site_id | AQ5 |
| Number of Residues | 3 |
| Details | binding site for residue FMT H 511 |
| Chain | Residue |
| H | ARG113 |
| H | LYS117 |
| H | LEU142 |
| site_id | AQ6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO H 512 |
| Chain | Residue |
| G | ARG85 |
| H | ASP303 |
| H | ASP305 |
| site_id | AQ7 |
| Number of Residues | 11 |
| Details | binding site for residue PEG H 513 |
| Chain | Residue |
| F | PEG829 |
| H | ALA134 |
| H | CYS137 |
| H | ALA138 |
| H | LEU142 |
| H | ASP143 |
| H | CYS144 |
| H | LEU166 |
| H | GLY167 |
| H | ALA168 |
| H | HOH607 |
| site_id | AQ8 |
| Number of Residues | 5 |
| Details | binding site for residue FMT H 514 |
| Chain | Residue |
| H | ASP274 |
| H | ARG280 |
| H | HIS312 |
| H | SER313 |
| H | ASP343 |
| site_id | AQ9 |
| Number of Residues | 6 |
| Details | binding site for residue FMT H 515 |
| Chain | Residue |
| F | ASP93 |
| F | LEU94 |
| H | HIS96 |
| H | THR97 |
| H | ARG392 |
| H | HOH709 |
| site_id | AR1 |
| Number of Residues | 4 |
| Details | binding site for residue FMT H 516 |
| Chain | Residue |
| E | ARG223 |
| H | ALA333 |
| H | GLY334 |
| H | HOH736 |
| site_id | AR2 |
| Number of Residues | 3 |
| Details | binding site for residue FMT H 517 |
| Chain | Residue |
| H | ARG164 |
| H | ALA168 |
| H | HOH628 |
| site_id | AR3 |
| Number of Residues | 2 |
| Details | binding site for residue FMT H 518 |
| Chain | Residue |
| H | GLU74 |
| H | GLN233 |
| site_id | AR4 |
| Number of Residues | 5 |
| Details | binding site for residue FMT H 519 |
| Chain | Residue |
| H | PHE269 |
| H | ARG339 |
| H | GLY371 |
| H | GLU378 |
| H | FMT522 |
| site_id | AR5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO H 520 |
| Chain | Residue |
| H | GLY273 |
| H | ASP274 |
| H | THR342 |
| H | ASP343 |
| H | SER344 |
| H | FMT524 |
| site_id | AR6 |
| Number of Residues | 1 |
| Details | binding site for residue EDO H 521 |
| Chain | Residue |
| H | ARG335 |
| site_id | AR7 |
| Number of Residues | 4 |
| Details | binding site for residue FMT H 522 |
| Chain | Residue |
| H | ARG339 |
| H | PRO340 |
| H | LYS374 |
| H | FMT519 |
| site_id | AR8 |
| Number of Residues | 4 |
| Details | binding site for residue FMT H 523 |
| Chain | Residue |
| H | ARG236 |
| H | LEU237 |
| H | PRO238 |
| H | GLY263 |
| site_id | AR9 |
| Number of Residues | 4 |
| Details | binding site for residue FMT H 524 |
| Chain | Residue |
| H | ASP274 |
| H | GLY275 |
| H | THR342 |
| H | EDO520 |
| site_id | AS1 |
| Number of Residues | 4 |
| Details | binding site for residue FMT H 525 |
| Chain | Residue |
| H | ARG265 |
| H | LEU266 |
| H | ARG335 |
| H | ASP337 |
| site_id | AS2 |
| Number of Residues | 4 |
| Details | binding site for residue FMT H 526 |
| Chain | Residue |
| H | LYS331 |
| H | ASP337 |
| H | TYR338 |
| H | FMT528 |
| site_id | AS3 |
| Number of Residues | 1 |
| Details | binding site for residue FMT H 527 |
| Chain | Residue |
| H | SER23 |
| site_id | AS4 |
| Number of Residues | 3 |
| Details | binding site for residue FMT H 528 |
| Chain | Residue |
| H | TYR338 |
| H | ARG339 |
| H | FMT526 |
| site_id | AS5 |
| Number of Residues | 3 |
| Details | binding site for residue FMT H 529 |
| Chain | Residue |
| H | ALA6 |
| H | ASP217 |
| H | ARG220 |
| site_id | AS6 |
| Number of Residues | 5 |
| Details | binding site for residue MLI H 530 |
| Chain | Residue |
| B | TRP403 |
| B | EDO516 |
| B | HOH664 |
| H | LYS402 |
| H | TRP403 |
| site_id | AS7 |
| Number of Residues | 6 |
| Details | binding site for residue K H 531 |
| Chain | Residue |
| H | GLY246 |
| H | ALA282 |
| H | THR284 |
| H | TYR320 |
| H | GLY322 |
| H | HOH752 |
| site_id | AS8 |
| Number of Residues | 7 |
| Details | binding site for residue EPE H 532 |
| Chain | Residue |
| D | GLY232 |
| D | GLY235 |
| F | TYR73 |
| H | LEU61 |
| H | ARG113 |
| H | LEU139 |
| H | HOH626 |
| site_id | AS9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO H 533 |
| Chain | Residue |
| D | ARG119 |
| H | GLN80 |
| H | MET356 |
| H | HOH634 |
| H | HOH708 |
Functional Information from PROSITE/UniProt
| site_id | PS00167 |
| Number of Residues | 14 |
| Details | TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. IEVGvPYSDPGMDG |
| Chain | Residue | Details |
| A | ILE56-GLY69 |
| site_id | PS00168 |
| Number of Residues | 15 |
| Details | TRP_SYNTHASE_BETA Tryptophan synthase beta chain pyridoxal-phosphate attachment site. LnHtGSHKiNnvLgQ |
| Chain | Residue | Details |
| B | LEU94-GLN108 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00131","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"HAMAP-Rule","id":"MF_00133","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
