6U62
Raptor-Rag-Ragulator complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Regulatory-associated protein of mTOR | polymer | 1392 | 154915.8 | 1 | UniProt (Q8N122) Pfam (PF14538) Pfam (PF02985) Pfam (PF00400) | Homo sapiens (Human) | Raptor,p150 target of rapamycin (TOR)-scaffold protein |
| 2 | B (B) | Ras-related GTP-binding protein A | polymer | 313 | 36615.2 | 1 | UniProt (Q7L523) Pfam (PF04670) | Homo sapiens (Human) | RagA,Adenovirus E3 14.7 kDa-interacting protein 1,FIP-1 |
| 3 | C (C) | Ras-related GTP-binding protein C | polymer | 400 | 44334.8 | 1 | UniProt (Q9HB90) Pfam (PF04670) | Homo sapiens (Human) | RagC,GTPase-interacting protein 2,TIB929 |
| 4 | D (D) | Ragulator complex protein LAMTOR1 | polymer | 158 | 17359.2 | 1 | UniProt (Q6IAA8) Pfam (PF15454) | Homo sapiens (Human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1,Lipid raft adaptor protein p18,Protein associated with DRMs and endosomes,p27Kip1-releasing factor from RhoA,p27RF-Rho |
| 5 | E (E) | Ragulator complex protein LAMTOR2 | polymer | 125 | 13517.5 | 1 | UniProt (Q9Y2Q5) Pfam (PF03259) | Homo sapiens (Human) | Endosomal adaptor protein p14,Late endosomal/lysosomal Mp1-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2,Mitogen-activated protein-binding protein-interacting protein,MAPBP-interacting protein,Roadblock domain-containing protein 3 |
| 6 | F (F) | Ragulator complex protein LAMTOR3 | polymer | 162 | 17579.8 | 1 | UniProt (Q9UHA4) Pfam (PF08923) | Homo sapiens (Human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3,MEK-binding partner 1,Mp1,Mitogen-activated protein kinase kinase 1-interacting protein 1,Mitogen-activated protein kinase scaffold protein 1 |
| 7 | G (G) | Ragulator complex protein LAMTOR4 | polymer | 100 | 10776.2 | 1 | UniProt (Q0VGL1) | Homo sapiens (Human) | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4 |
| 8 | H (H) | Ragulator complex protein LAMTOR5 | polymer | 91 | 9622.9 | 1 | UniProt (O43504) Pfam (PF16672) | Homo sapiens (Human) | Hepatitis B virus X-interacting protein,HBX-interacting protein,Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 |
| 9 | I (B) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 10 | J (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 11 | K (C) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) |
Sequence modifications
A: 1 - 1335 (UniProt: Q8N122)
C: 2 - 399 (UniProt: Q9HB90)
D: 6 - 161 (UniProt: Q6IAA8)
F: 1 - 124 (UniProt: Q9UHA4)
G: 2 - 99 (UniProt: Q0VGL1)
| PDB | External Database | Details |
|---|---|---|
| Gly 1336 | - | expression tag |
| Gly 1337 | - | expression tag |
| Gly 1338 | - | expression tag |
| Ser 1339 | - | expression tag |
| Leu 1340 | - | expression tag |
| Glu 1341 | - | expression tag |
| Val 1342 | - | expression tag |
| Leu 1343 | - | expression tag |
| Phe 1344 | - | expression tag |
| Gln 1345 | - | expression tag |
| Gly 1346 | - | expression tag |
| Pro 1347 | - | expression tag |
| Gly 1348 | - | expression tag |
| Ser 1349 | - | expression tag |
| Gly 1350 | - | expression tag |
| Gly 1351 | - | expression tag |
| Gly 1352 | - | expression tag |
| Ser 1353 | - | expression tag |
| Asp 1354 | - | expression tag |
| Tyr 1355 | - | expression tag |
| Lys 1356 | - | expression tag |
| Asp 1357 | - | expression tag |
| Asp 1358 | - | expression tag |
| Asp 1359 | - | expression tag |
| Asp 1360 | - | expression tag |
| Lys 1361 | - | expression tag |
| Ser 1362 | - | expression tag |
| Ser 1363 | - | expression tag |
| Gly 1364 | - | expression tag |
| Trp 1365 | - | expression tag |
| Ser 1366 | - | expression tag |
| His 1367 | - | expression tag |
| Pro 1368 | - | expression tag |
| Gln 1369 | - | expression tag |
| Phe 1370 | - | expression tag |
| Glu 1371 | - | expression tag |
| Lys 1372 | - | expression tag |
| Gly 1373 | - | expression tag |
| Gly 1374 | - | expression tag |
| Gly 1375 | - | expression tag |
| Ala 1376 | - | expression tag |
| Arg 1377 | - | expression tag |
| Gly 1378 | - | expression tag |
| Gly 1379 | - | expression tag |
| Ser 1380 | - | expression tag |
| Gly 1381 | - | expression tag |
| Gly 1382 | - | expression tag |
| Gly 1383 | - | expression tag |
| Ser 1384 | - | expression tag |
| Trp 1385 | - | expression tag |
| Ser 1386 | - | expression tag |
| His 1387 | - | expression tag |
| Pro 1388 | - | expression tag |
| Gln 1389 | - | expression tag |
| Phe 1390 | - | expression tag |
| Glu 1391 | - | expression tag |
| Lys 1392 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Pro 1 | - | expression tag |
| Asn 75 | Ser 75 | engineered mutation |
| Asn 90 | Thr 90 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 4 | - | expression tag |
| Pro 5 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glu 125 | - | expression tag |
| Asn 126 | - | expression tag |
| Leu 127 | - | expression tag |
| Tyr 128 | - | expression tag |
| Phe 129 | - | expression tag |
| Gln 130 | - | expression tag |
| Gly 131 | - | expression tag |
| Ser 132 | - | expression tag |
| Ser 133 | - | expression tag |
| Gly 134 | - | expression tag |
| Trp 135 | - | expression tag |
| Ser 136 | - | expression tag |
| His 137 | - | expression tag |
| Pro 138 | - | expression tag |
| Gln 139 | - | expression tag |
| Phe 140 | - | expression tag |
| Glu 141 | - | expression tag |
| Lys 142 | - | expression tag |
| Gly 143 | - | expression tag |
| Gly 144 | - | expression tag |
| Gly 145 | - | expression tag |
| Ser 146 | - | expression tag |
| Gly 147 | - | expression tag |
| Gly 148 | - | expression tag |
| Gly 149 | - | expression tag |
| Ser 150 | - | expression tag |
| Gly 151 | - | expression tag |
| Gly 152 | - | expression tag |
| Gly 153 | - | expression tag |
| Ser 154 | - | expression tag |
| Trp 155 | - | expression tag |
| Ser 156 | - | expression tag |
| His 157 | - | expression tag |
| Pro 158 | - | expression tag |
| Gln 159 | - | expression tag |
| Phe 160 | - | expression tag |
| Glu 161 | - | expression tag |
| Lys 162 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Pro 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 304721.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 990.7 | |
| All* | Total formula weight | 305712.1 |
