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6U62

Raptor-Rag-Ragulator complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0001558biological_processregulation of cell growth
A0001938biological_processpositive regulation of endothelial cell proliferation
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005829cellular_componentcytosol
A0006974biological_processDNA damage response
A0008361biological_processregulation of cell size
A0009267biological_processcellular response to starvation
A0009410biological_processresponse to xenobiotic stimulus
A0010494cellular_componentcytoplasmic stress granule
A0010506biological_processregulation of autophagy
A0010507biological_processnegative regulation of autophagy
A0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
A0016020cellular_componentmembrane
A0019901molecular_functionprotein kinase binding
A0030291molecular_functionprotein serine/threonine kinase inhibitor activity
A0030295molecular_functionprotein kinase activator activity
A0030307biological_processpositive regulation of cell growth
A0030425cellular_componentdendrite
A0030674molecular_functionprotein-macromolecule adaptor activity
A0031267molecular_functionsmall GTPase binding
A0031669biological_processcellular response to nutrient levels
A0031929biological_processTOR signaling
A0031931cellular_componentTORC1 complex
A0032008biological_processpositive regulation of TOR signaling
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0035176biological_processsocial behavior
A0038202biological_processTORC1 signaling
A0042325biological_processregulation of phosphorylation
A0043025cellular_componentneuronal cell body
A0044877molecular_functionprotein-containing complex binding
A0045672biological_processpositive regulation of osteoclast differentiation
A0045821biological_processpositive regulation of glycolytic process
A0045945biological_processpositive regulation of transcription by RNA polymerase III
A0046889biological_processpositive regulation of lipid biosynthetic process
A0071230biological_processcellular response to amino acid stimulus
A0071233biological_processcellular response to L-leucine
A0071333biological_processcellular response to glucose stimulus
A0071456biological_processcellular response to hypoxia
A0071470biological_processcellular response to osmotic stress
A0071889molecular_function14-3-3 protein binding
A0140767molecular_functionenzyme-substrate adaptor activity
A1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
A1901331biological_processpositive regulation of odontoblast differentiation
A1905857biological_processpositive regulation of pentose-phosphate shunt
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0006915biological_processapoptotic process
B0008104biological_processprotein localization
B0009267biological_processcellular response to starvation
B0010507biological_processnegative regulation of autophagy
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0031625molecular_functionubiquitin protein ligase binding
B0031669biological_processcellular response to nutrient levels
B0032008biological_processpositive regulation of TOR signaling
B0033209biological_processtumor necrosis factor-mediated signaling pathway
B0034198biological_processcellular response to amino acid starvation
B0035556biological_processintracellular signal transduction
B0042593biological_processglucose homeostasis
B0042803molecular_functionprotein homodimerization activity
B0043495molecular_functionprotein-membrane adaptor activity
B0046982molecular_functionprotein heterodimerization activity
B0051219molecular_functionphosphoprotein binding
B0061462biological_processprotein localization to lysosome
B0071230biological_processcellular response to amino acid stimulus
B0072657biological_processprotein localization to membrane
B1904263biological_processpositive regulation of TORC1 signaling
B1990130cellular_componentGATOR1 complex
B1990131cellular_componentGtr1-Gtr2 GTPase complex
B1990877cellular_componentFNIP-folliculin RagC/D GAP
C0000287molecular_functionmagnesium ion binding
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0006351biological_processDNA-templated transcription
C0006915biological_processapoptotic process
C0007264biological_processsmall GTPase-mediated signal transduction
C0008104biological_processprotein localization
C0008380biological_processRNA splicing
C0009267biological_processcellular response to starvation
C0010507biological_processnegative regulation of autophagy
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0019003molecular_functionGDP binding
C0031669biological_processcellular response to nutrient levels
C0032006biological_processregulation of TOR signaling
C0034198biological_processcellular response to amino acid starvation
C0043200biological_processresponse to amino acid
C0043231cellular_componentintracellular membrane-bounded organelle
C0043495molecular_functionprotein-membrane adaptor activity
C0046982molecular_functionprotein heterodimerization activity
C0051020molecular_functionGTPase binding
C0060090molecular_functionmolecular adaptor activity
C0061462biological_processprotein localization to lysosome
C0071230biological_processcellular response to amino acid stimulus
C0072657biological_processprotein localization to membrane
C0140767molecular_functionenzyme-substrate adaptor activity
C1903432biological_processregulation of TORC1 signaling
C1904263biological_processpositive regulation of TORC1 signaling
C1990131cellular_componentGtr1-Gtr2 GTPase complex
C1990877cellular_componentFNIP-folliculin RagC/D GAP
D0001558biological_processregulation of cell growth
D0001919biological_processregulation of receptor recycling
D0005085molecular_functionguanyl-nucleotide exchange factor activity
D0005515molecular_functionprotein binding
D0005764cellular_componentlysosome
D0005765cellular_componentlysosomal membrane
D0005768cellular_componentendosome
D0005886cellular_componentplasma membrane
D0007032biological_processendosome organization
D0007040biological_processlysosome organization
D0008104biological_processprotein localization
D0010874biological_processregulation of cholesterol efflux
D0016020cellular_componentmembrane
D0016197biological_processendosomal transport
D0031669biological_processcellular response to nutrient levels
D0031902cellular_componentlate endosome membrane
D0032008biological_processpositive regulation of TOR signaling
D0032418biological_processlysosome localization
D0035577cellular_componentazurophil granule membrane
D0035579cellular_componentspecific granule membrane
D0038202biological_processTORC1 signaling
D0042632biological_processcholesterol homeostasis
D0043410biological_processpositive regulation of MAPK cascade
D0043495molecular_functionprotein-membrane adaptor activity
D0045121cellular_componentmembrane raft
D0051020molecular_functionGTPase binding
D0060090molecular_functionmolecular adaptor activity
D0060620biological_processregulation of cholesterol import
D0070062cellular_componentextracellular exosome
D0071230biological_processcellular response to amino acid stimulus
D0071986cellular_componentRagulator complex
D0072657biological_processprotein localization to membrane
D0101003cellular_componentficolin-1-rich granule membrane
D0150032biological_processpositive regulation of protein localization to lysosome
D1904263biological_processpositive regulation of TORC1 signaling
D1990877cellular_componentFNIP-folliculin RagC/D GAP
E0001558biological_processregulation of cell growth
E0005085molecular_functionguanyl-nucleotide exchange factor activity
E0005515molecular_functionprotein binding
E0005764cellular_componentlysosome
E0005765cellular_componentlysosomal membrane
E0005768cellular_componentendosome
E0005770cellular_componentlate endosome
E0005886cellular_componentplasma membrane
E0008104biological_processprotein localization
E0010008cellular_componentendosome membrane
E0010761biological_processfibroblast migration
E0016020cellular_componentmembrane
E0031902cellular_componentlate endosome membrane
E0032008biological_processpositive regulation of TOR signaling
E0035579cellular_componentspecific granule membrane
E0038202biological_processTORC1 signaling
E0043410biological_processpositive regulation of MAPK cascade
E0060090molecular_functionmolecular adaptor activity
E0070821cellular_componenttertiary granule membrane
E0071230biological_processcellular response to amino acid stimulus
E0071986cellular_componentRagulator complex
E0150116biological_processregulation of cell-substrate junction organization
E1902414biological_processprotein localization to cell junction
E1904263biological_processpositive regulation of TORC1 signaling
E1990877cellular_componentFNIP-folliculin RagC/D GAP
F0005085molecular_functionguanyl-nucleotide exchange factor activity
F0005515molecular_functionprotein binding
F0005765cellular_componentlysosomal membrane
F0005768cellular_componentendosome
F0005770cellular_componentlate endosome
F0005886cellular_componentplasma membrane
F0005925cellular_componentfocal adhesion
F0008104biological_processprotein localization
F0010008cellular_componentendosome membrane
F0016020cellular_componentmembrane
F0019209molecular_functionkinase activator activity
F0031902cellular_componentlate endosome membrane
F0032006biological_processregulation of TOR signaling
F0032008biological_processpositive regulation of TOR signaling
F0035579cellular_componentspecific granule membrane
F0038202biological_processTORC1 signaling
F0043410biological_processpositive regulation of MAPK cascade
F0060090molecular_functionmolecular adaptor activity
F0070062cellular_componentextracellular exosome
F0070821cellular_componenttertiary granule membrane
F0071230biological_processcellular response to amino acid stimulus
F0071986cellular_componentRagulator complex
F1902414biological_processprotein localization to cell junction
F1904263biological_processpositive regulation of TORC1 signaling
F1990877cellular_componentFNIP-folliculin RagC/D GAP
G0005085molecular_functionguanyl-nucleotide exchange factor activity
G0005515molecular_functionprotein binding
G0005764cellular_componentlysosome
G0005765cellular_componentlysosomal membrane
G0008361biological_processregulation of cell size
G0031902cellular_componentlate endosome membrane
G0032008biological_processpositive regulation of TOR signaling
G0038202biological_processTORC1 signaling
G0043231cellular_componentintracellular membrane-bounded organelle
G0060090molecular_functionmolecular adaptor activity
G0061462biological_processprotein localization to lysosome
G0071230biological_processcellular response to amino acid stimulus
G0071986cellular_componentRagulator complex
G1904263biological_processpositive regulation of TORC1 signaling
G1990877cellular_componentFNIP-folliculin RagC/D GAP
H0005085molecular_functionguanyl-nucleotide exchange factor activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005764cellular_componentlysosome
H0005765cellular_componentlysosomal membrane
H0005829cellular_componentcytosol
H0008361biological_processregulation of cell size
H0009615biological_processresponse to virus
H0010628biological_processpositive regulation of gene expression
H0019079biological_processviral genome replication
H0031902cellular_componentlate endosome membrane
H0032008biological_processpositive regulation of TOR signaling
H0032757biological_processpositive regulation of interleukin-8 production
H0032991cellular_componentprotein-containing complex
H0038202biological_processTORC1 signaling
H0043066biological_processnegative regulation of apoptotic process
H0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
H0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
H0051092biological_processpositive regulation of NF-kappaB transcription factor activity
H0060090molecular_functionmolecular adaptor activity
H0061462biological_processprotein localization to lysosome
H0071230biological_processcellular response to amino acid stimulus
H0071986cellular_componentRagulator complex
H1900182biological_processpositive regulation of protein localization to nucleus
H1904263biological_processpositive regulation of TORC1 signaling
H1905636biological_processpositive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
H1990877cellular_componentFNIP-folliculin RagC/D GAP
Functional Information from PDB Data
site_idAC1
Number of Residues19
Detailsbinding site for residue GTP B 401
ChainResidue
BSER16
BALA41
BTHR42
BGLY65
BHIS127
BLYS128
BASP130
BSER163
BILE164
BTRP165
BMG402
BGLY17
BSER18
BGLY19
BLYS20
BTHR21
BSER22
BTHR36
BARG37

site_idAC2
Number of Residues3
Detailsbinding site for residue MG B 402
ChainResidue
BTHR21
BTHR42
BGTP401

site_idAC3
Number of Residues14
Detailsbinding site for residue GDP C 401
ChainResidue
AGLU935
CLEU69
CARG71
CSER72
CGLY73
CLYS74
CASN75
CSER76
CHIS178
CLYS179
CASP181
CSER219
CILE220
CTYR221

Functional Information from PROSITE/UniProt
site_idPS00214
Number of Residues18
DetailsFABP Cytosolic fatty-acid binding proteins signature. KAYkVnpDmNFEvFIHKV
ChainResidueDetails
CLYS163-VAL180

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|Ref.8, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:25944712
ChainResidueDetails
HMET1
BGLY17
BHIS127
ASER982

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:31314152
ChainResidueDetails
GSER67
DSER56
DSER98
DSER141

site_idSWS_FT_FI3
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36476874
ChainResidueDetails
DLYS20
DLYS31
DLYS60
BILE164

site_idSWS_FT_FI4
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q9CQ22
ChainResidueDetails
CLYS74
DLYS103
DLYS104

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:31601764, ECO:0000269|PubMed:32868926, ECO:0000269|PubMed:35338845, ECO:0000269|PubMed:36697823, ECO:0007744|PDB:6SB0, ECO:0007744|PDB:6SB2, ECO:0007744|PDB:6U62, ECO:0007744|PDB:6WJ2, ECO:0007744|PDB:6WJ3, ECO:0007744|PDB:7T3B, ECO:0007744|PDB:7UX2, ECO:0007744|PDB:7UXC, ECO:0007744|PDB:7UXH
ChainResidueDetails
CASN75
BGLY65

site_idSWS_FT_FI6
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:31601764, ECO:0000269|PubMed:35338845, ECO:0000269|PubMed:36697823, ECO:0007744|PDB:6SB0, ECO:0007744|PDB:6SB2, ECO:0007744|PDB:7T3C, ECO:0007744|PDB:7UX2, ECO:0007744|PDB:7UXC, ECO:0007744|PDB:7UXH
ChainResidueDetails
CSER76

site_idSWS_FT_FI7
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:32868926, ECO:0007744|PDB:6WJ2, ECO:0007744|PDB:6WJ3
ChainResidueDetails
CASN90
CTHR96
CASP181

site_idSWS_FT_FI8
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:35338845, ECO:0007744|PDB:7T3B, ECO:0007744|PDB:7T3C
ChainResidueDetails
CGLU94

site_idSWS_FT_FI9
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:32868926, ECO:0000269|PubMed:36697823, ECO:0007744|PDB:6U62, ECO:0007744|PDB:6WJ2, ECO:0007744|PDB:6WJ3, ECO:0007744|PDB:7UX2, ECO:0007744|PDB:7UXC, ECO:0007744|PDB:7UXH
ChainResidueDetails
CHIS178
BLYS220
BLYS230
BLYS244

site_idSWS_FT_FI10
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:31601708, ECO:0000269|PubMed:35338845, ECO:0000269|PubMed:36697823, ECO:0007744|PDB:6U62, ECO:0007744|PDB:7T3B, ECO:0007744|PDB:7UX2, ECO:0007744|PDB:7UXC, ECO:0007744|PDB:7UXH
ChainResidueDetails
CLYS179
CILE220

site_idSWS_FT_FI11
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:35338845, ECO:0000269|PubMed:36697823, ECO:0007744|PDB:7T3B, ECO:0007744|PDB:7UX2, ECO:0007744|PDB:7UXC, ECO:0007744|PDB:7UXH
ChainResidueDetails
CSER219

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER2

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER15

site_idSWS_FT_FI14
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q99K70
ChainResidueDetails
CTHR96

site_idSWS_FT_FI15
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:32561715
ChainResidueDetails
ALYS1097

site_idSWS_FT_FI16
Number of Residues1
DetailsCARBOHYD: O-linked (GlcNAc) threonine => ECO:0000269|PubMed:37541260
ChainResidueDetails
ATHR700

site_idSWS_FT_FI17
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:35927303
ChainResidueDetails
ALYS932
ALYS948

222415

PDB entries from 2024-07-10

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