6U2F
PCSK9-Fab 7G7 complex bound to cis-1-amino-4-phenylcyclohexaneacyl-WNLK(hR)IGLLR - NH2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Proprotein convertase subtilisin/kexin type 9 | polymer | 700 | 75508.4 | 1 | UniProt (Q8NBP7) Pfam (PF05922) Pfam (PF00082) Pfam (PF18459) Pfam (PF18464) Pfam (PF18463) | Homo sapiens (Human) | Neural apoptosis-regulated convertase 1, NARC-1, Proprotein convertase 9, PC9, Subtilisin/kexin-like protease PC9, PCSK9 |
| 2 | B (B) | Organo-peptide PCSK9 inhibitor | polymer | 11 | 1485.9 | 1 | BIRD (PRD_002363) | synthetic construct | |
| 3 | C (H) | 7G7 heavy chain | polymer | 223 | 24117.9 | 1 | UniProt (Q569X1) Pfam (PF07686) Pfam (PF07654) | Mus musculus (Mouse) | |
| 4 | D (L) | 7G7 light chain | polymer | 214 | 23659.1 | 1 | UniProt (A0A0U5BC76) Pfam (PF07686) Pfam (PF07654) | Mus musculus (Mouse) | |
| 5 | E (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 6 | F, G, H (A, H, L) | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
A: 1 - 692 (UniProt: Q8NBP7)
H: 1 - 120 (PDB: 6U2F)
H: 121 - 223 (UniProt: Q569X1)
L: 1 - 106 (PDB: 6U2F)
L: 107 - 214 (UniProt: A0A0U5BC76)
| PDB | External Database | Details |
|---|---|---|
| Ile 474 | Val 474 | variant |
| Glu 660 | Asp 660 | variant |
| His 693 | - | expression tag |
| His 694 | - | expression tag |
| His 695 | - | expression tag |
| His 696 | - | expression tag |
| His 697 | - | expression tag |
| His 698 | - | expression tag |
| His 699 | - | expression tag |
| His 700 | - | expression tag |
H: 121 - 223 (UniProt: Q569X1)
L: 1 - 106 (PDB: 6U2F)
L: 107 - 214 (UniProt: A0A0U5BC76)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 124771.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 40.1 | |
| All* | Total formula weight | 124811.3 |
