6U2F

PCSK9-Fab 7G7 complex bound to cis-1-amino-4-phenylcyclohexaneacyl-WNLK(hR)IGLLR - NH2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
L	0005615	cellular_component	extracellular space
L	0006955	biological_process	immune response

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CA A 801

Chain	Residue
A	GLY106
A	CYS552
A	GLN554
A	HIS557

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR192-HIS198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240

Chain	Residue	Details
A	ASP186
A	HIS226
A	SER386

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage; by autolysis => ECO:0000269|PubMed:14622975

Chain	Residue	Details
A	GLN152

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by furin and PCSK5 => ECO:0000269|PubMed:16912035

Chain	Residue	Details
A	ARG218

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Sulfotyrosine => ECO:0000269|PubMed:16912035

Chain	Residue	Details
A	TYR38

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:18498363, ECO:0000269|PubMed:26091039

Chain	Residue	Details
A	SER47

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:18498363, ECO:0000269|PubMed:26091039, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER688

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site_id	SWS_FT_FI7
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16912035

Chain	Residue	Details
A	ASN533

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