6U0L
Asymmetrically open conformational state (Class I) of HIV-1 Env trimer BG505 SOSIP.664 in complex with sCD4 and E51 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Envelope glycoprotein gp120 | polymer | 481 | 54064.3 | 3 | UniProt (Q2N0S6) | Human immunodeficiency virus 1 | |
| 2 | D, E, F (D, E, F) | T-cell surface glycoprotein CD4 | polymer | 192 | 21472.3 | 3 | UniProt (P01730) Pfam (PF00047) Pfam (PF05790) | Homo sapiens (Human) | |
| 3 | G, H, K (H, I, P) | E51 Fab heavy chain | polymer | 235 | 24891.6 | 3 | Homo sapiens (Human) | ||
| 4 | I, J, L (J, L, Q) | E51 Fab light chain | polymer | 213 | 22352.6 | 3 | Homo sapiens (Human) | ||
| 5 | M, N, O (X, Y, Z) | Envelope glycoprotein gp41 | polymer | 153 | 17146.5 | 3 | UniProt (Q2N0S6) | Human immunodeficiency virus 1 | |
| 6 | P, R, S, U (G, M, N, R) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 7 | Q, V (K, S) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G42227JK) | |||
| 8 | T (O) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G07617FP) | |||
| 9 | AA, BA, CA, DA, EA... (A, B, C, X) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 21 | Chemie (NAG) |
Sequence modifications
A, B, C: 31 - 508 (UniProt: Q2N0S6)
D, E, F: 1 - 182 (UniProt: P01730)
X, Y, Z: 512 - 664 (UniProt: Q2N0S6)
| PDB | External Database | Details |
|---|---|---|
| Asn 332 | Thr 330 | conflict |
| Cys 501 | Ala 498 | conflict |
| Arg 509 | - | expression tag |
| Arg 510 | - | expression tag |
| Arg 511 | - | expression tag |
| Arg 512 | - | expression tag |
| Arg 513 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ile 183 | - | expression tag |
| Asp 184 | - | expression tag |
| Gly 185 | - | expression tag |
| Arg 186 | - | expression tag |
| His 187 | - | expression tag |
| His 188 | - | expression tag |
| His 189 | - | expression tag |
| His 190 | - | expression tag |
| His 191 | - | expression tag |
| His 192 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Pro 559 | Ile 556 | conflict |
| Cys 605 | Thr 602 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 15 |
| Total formula weight | 419782.0 | |
| Branched | Number of molecules | 7 |
| Total formula weight | 4754.4 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 4645.4 | |
| All* | Total formula weight | 429181.7 |
