6TXA
Crystal structure of tetrameric human D137N-SAMHD1 (residues 109-626) with XTP, dGMPNPP and Mg
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | polymer | 520 | 60207.8 | 16 | UniProt (Q9Y3Z3) Pfam (PF01966) | Homo sapiens (Human) | dNTPase,Dendritic cell-derived IFNG-induced protein,DCIP,Monocyte protein 5,MOP-5,SAM domain and HD domain-containing protein 1,hSAMHD1 |
| 2 | BD, CC, EB, HA, HE... (L, I, F, C, P...) | FE (III) ION | non-polymer | 55.8 | 16 | Chemie (FE) | |||
| 3 | AA, AE, BA, BE, CD... (B, O, L, I, F...) | MAGNESIUM ION | non-polymer | 24.3 | 48 | Chemie (MG) | |||
| 4 | AB, CA, DB, DE, FA... (E, B, O, L, C...) | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine | non-polymer | 506.2 | 32 | Chemie (XG4) | |||
| 5 | AC, BB, DA, EE, GD... (H, E, B, O, L...) | [[(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | non-polymer | 524.2 | 16 | Chemie (CZF) | |||
| 6 | AD, BC, CB, EA, FE... (K, H, E, B, O...) | SULFATE ION | non-polymer | 96.1 | 15 | Chemie (SO4) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P: 109 - 626 (UniProt: Q9Y3Z3)
| PDB | External Database | Details |
|---|---|---|
| Gly 107 | - | expression tag |
| Ser 108 | - | expression tag |
| Asn 137 | Asp 137 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 963325.1 | |
| Non-Polymers* | Number of molecules | 127 |
| Total formula weight | 28086.0 | |
| All* | Total formula weight | 991411.1 |
