6TRX
Crystal structure of DPP8 in complex with 1G244
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (B, A, C) | Dipeptidyl peptidase 8 | polymer | 903 | 103886.8 | 3 | UniProt (Q6V1X1) Pfam (PF19520) Pfam (PF00930) Pfam (PF00326) | Homo sapiens (Human) | DP8,Dipeptidyl peptidase IV-related protein 1,DPRP-1,Dipeptidyl peptidase VIII,DPP VIII,Prolyl dipeptidase DPP8 |
| 2 | D, H, L (B, A, C) | trimethylamine oxide | non-polymer | 75.1 | 3 | Chemie (TMO) | |||
| 3 | E, I, M (B, A, C) | (2~{S})-2-azanyl-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione | non-polymer | 504.6 | 3 | Chemie (9XH) | |||
| 4 | F, J, N (B, A, C) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 5 | G, K, O (B, A, C) | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) | |||
| 6 | P, Q, R (B, A, C) | water | water | 18.0 | 127 | Chemie (HOH) |
Sequence modifications
B, A, C: 1 - 898 (UniProt: Q6V1X1)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 311660.4 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2092.9 | |
| All* | Total formula weight | 313753.4 |
