6TRX
Crystal structure of DPP8 in complex with 1G244
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006508 | biological_process | proteolysis |
| A | 0006915 | biological_process | apoptotic process |
| A | 0006955 | biological_process | immune response |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0008239 | molecular_function | dipeptidyl-peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0043069 | biological_process | negative regulation of programmed cell death |
| B | 0004177 | molecular_function | aminopeptidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006508 | biological_process | proteolysis |
| B | 0006915 | biological_process | apoptotic process |
| B | 0006955 | biological_process | immune response |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0008239 | molecular_function | dipeptidyl-peptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0043069 | biological_process | negative regulation of programmed cell death |
| C | 0004177 | molecular_function | aminopeptidase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006508 | biological_process | proteolysis |
| C | 0006915 | biological_process | apoptotic process |
| C | 0006955 | biological_process | immune response |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0008239 | molecular_function | dipeptidyl-peptidase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0043069 | biological_process | negative regulation of programmed cell death |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue TMO B 1001 |
| Chain | Residue |
| B | THR317 |
| B | ARG325 |
| B | ALA326 |
| C | HIS315 |
| C | THR317 |
| C | TMO901 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | binding site for residue 9XH B 1002 |
| Chain | Residue |
| B | HIS525 |
| B | TYR669 |
| B | GLN673 |
| B | LEU676 |
| B | TYR686 |
| B | SER755 |
| B | TYR756 |
| B | VAL781 |
| B | TYR787 |
| B | TYR791 |
| B | ASN835 |
| B | VAL836 |
| B | HIS865 |
| B | HOH1151 |
| B | ARG160 |
| B | GLU275 |
| B | GLU276 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 1003 |
| Chain | Residue |
| B | ARG158 |
| B | GLN274 |
| B | GLU275 |
| B | ASP278 |
| B | TYR280 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 B 1004 |
| Chain | Residue |
| B | ASN528 |
| B | GLU541 |
| B | CYS575 |
| B | CYS576 |
| B | ILE577 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue TMO A 901 |
| Chain | Residue |
| A | HIS315 |
| A | THR317 |
| A | ARG324 |
| A | ARG325 |
| A | HIS837 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue 9XH A 902 |
| Chain | Residue |
| A | ARG160 |
| A | GLU275 |
| A | GLU276 |
| A | TYR669 |
| A | VAL674 |
| A | SER755 |
| A | TYR756 |
| A | VAL781 |
| A | TYR787 |
| A | TYR791 |
| A | ASN835 |
| A | HIS865 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 903 |
| Chain | Residue |
| A | ARG158 |
| A | GLN274 |
| A | GLU275 |
| A | ASP278 |
| A | TYR280 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 A 904 |
| Chain | Residue |
| A | SER527 |
| A | ASN528 |
| A | ILE529 |
| A | GLN530 |
| A | GLU541 |
| A | LEU552 |
| A | CYS575 |
| A | CYS576 |
| A | ILE577 |
| A | HOH1007 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue TMO C 901 |
| Chain | Residue |
| B | HIS315 |
| B | THR317 |
| B | TMO1001 |
| C | THR317 |
| C | ARG324 |
| C | ARG325 |
| site_id | AD1 |
| Number of Residues | 14 |
| Details | binding site for residue 9XH C 902 |
| Chain | Residue |
| C | ARG160 |
| C | GLU275 |
| C | GLU276 |
| C | HIS525 |
| C | TYR669 |
| C | LEU676 |
| C | TYR686 |
| C | SER755 |
| C | TYR756 |
| C | VAL781 |
| C | TYR787 |
| C | TYR791 |
| C | ASN835 |
| C | HIS865 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue NA C 903 |
| Chain | Residue |
| C | ARG158 |
| C | GLN274 |
| C | GLU275 |
| C | ASP278 |
| C | TYR280 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 C 904 |
| Chain | Residue |
| C | ASN528 |
| C | ILE529 |
| C | GLN530 |
| C | GLU541 |
| C | LEU552 |
| C | CYS575 |
| C | CYS576 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 9 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"12534281","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"29382749","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
