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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6TPK

Crystal structure of the human oxytocin receptor

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Oxytocin receptorpolymer50256162.51UniProt (P30559)
Pfam (PF00001)		Homo sapiens (Human)OT-R
2B
(A)		(3~{R},6~{R})-6-[(2~{S})-butan-2-yl]-3-(2,3-dihydro-1~{H}-inden-2-yl)-1-[(1~{R})-1-(2-methyl-1,3-oxazol-4-yl)-2-morpholin-4-yl-2-oxidanylidene-ethyl]piperazine-2,5-dionenon-polymer494.61Chemie (NU2)
3C
(A)		CHOLESTEROLnon-polymer386.71Chemie (CLR)
4D
(A)		DI(HYDROXYETHYL)ETHERnon-polymer106.11Chemie (PEG)
Sequence modifications
A: 35 - 356 (UniProt: P30559)
PDBExternal DatabaseDetails
His 65Arg 65conflict
Leu 120Val 120conflict
Ala 153Asp 153conflict
Val 167Ala 167conflict
Arg 193Gln 193conflict
Thr 218Ala 218conflict
Ala 224Ser 224conflict
Cys 322Ser 322conflict
Lys 325Asn 325conflict
Met 333Thr 333conflict
Gly 339Glu 339conflict
Ile 340Leu 340conflict
Asp 341Val 341conflict
Ycm 342Gln 342conflict
Ser 343Arg 343conflict
Trp 345Leu 345conflict
Asn 348Ser 348conflict
Glu 349Ala 349conflict
Thr 353Lys 353conflict
Ser 355Arg 355conflict
Asp 357-expression tag
Glu 358-expression tag
Arg 359-expression tag
Lys 360-expression tag
Lys 361-expression tag
Ser 362-expression tag
Leu 363-expression tag
Leu 364-expression tag
Ser 365-expression tag
Lys 366-expression tag
Phe 367-expression tag
Gly 368-expression tag
Met 369-expression tag
Asp 370-expression tag
Glu 371-expression tag
Gly 372-expression tag
Val 373-expression tag
Thr 374-expression tag
Phe 375-expression tag
Met 376-expression tag
Phe 377-expression tag
Ile 378-expression tag
Gly 379-expression tag
Arg 380-expression tag
Phe 381-expression tag
Asp 382-expression tag
Arg 383-expression tag
Gly 384-expression tag
Gln 385-expression tag
Lys 386-expression tag
Gly 387-expression tag
Val 388-expression tag
Asp 389-expression tag
Val 390-expression tag
Leu 391-expression tag
Leu 392-expression tag
Lys 393-expression tag
Ala 394-expression tag
Ile 395-expression tag
Glu 396-expression tag
Ile 397-expression tag
Leu 398-expression tag
Ser 399-expression tag
Ser 400-expression tag
Lys 401-expression tag
Lys 402-expression tag
Glu 403-expression tag
Phe 404-expression tag
Gln 405-expression tag
Glu 406-expression tag
Met 407-expression tag
Arg 408-expression tag
Phe 409-expression tag
Ile 410-expression tag
Ile 411-expression tag
Ile 412-expression tag
Gly 413-expression tag
Lys 414-expression tag
Gly 415-expression tag
Asp 416-expression tag
Pro 417-expression tag
Glu 418-expression tag
Leu 419-expression tag
Glu 420-expression tag
Gly 421-expression tag
Trp 422-expression tag
Ala 423-expression tag
Arg 424-expression tag
Ser 425-expression tag
Leu 426-expression tag
Glu 427-expression tag
Glu 428-expression tag
Lys 429-expression tag
His 430-expression tag
Gly 431-expression tag
Asn 432-expression tag
Val 433-expression tag
Lys 434-expression tag
Val 435-expression tag
Ile 436-expression tag
Thr 437-expression tag
Glu 438-expression tag
Met 439-expression tag
Leu 440-expression tag
Ser 441-expression tag
Arg 442-expression tag
Glu 443-expression tag
Phe 444-expression tag
Val 445-expression tag
Arg 446-expression tag
Glu 447-expression tag
Leu 448-expression tag
Tyr 449-expression tag
Gly 450-expression tag
Ser 451-expression tag
Val 452-expression tag
Asp 453-expression tag
Phe 454-expression tag
Val 455-expression tag
Ile 456-expression tag
Ile 457-expression tag
Pro 458-expression tag
Ser 459-expression tag
Tyr 460-expression tag
Phe 461-expression tag
Glu 462-expression tag
Pro 463-expression tag
Phe 464-expression tag
Gly 465-expression tag
Leu 466-expression tag
Val 467-expression tag
Ala 468-expression tag
Leu 469-expression tag
Glu 470-expression tag
Ala 471-expression tag
Met 472-expression tag
Cys 473-expression tag
Leu 474-expression tag
Gly 475-expression tag
Ala 476-expression tag
Ile 477-expression tag
Pro 478-expression tag
Ile 479-expression tag
Ala 480-expression tag
Ser 481-expression tag
Ala 482-expression tag
Val 483-expression tag
Gly 484-expression tag
Gly 485-expression tag
Leu 486-expression tag
Arg 487-expression tag
Asp 488-expression tag
Ile 489-expression tag
Ile 490-expression tag
Thr 491-expression tag
Asn 492-expression tag
Glu 493-expression tag
Thr 494-expression tag
Gly 495-expression tag
Ile 496-expression tag
Leu 497-expression tag
Val 498-expression tag
Lys 499-expression tag
Ala 500-expression tag
Gly 501-expression tag
Asp 502-expression tag
Pro 503-expression tag
Gly 504-expression tag
Glu 505-expression tag
Leu 506-expression tag
Ala 507-expression tag
Asn 508-expression tag
Ala 509-expression tag
Ile 510-expression tag
Leu 511-expression tag
Lys 512-expression tag
Ala 513-expression tag
Leu 514-expression tag
Glu 515-expression tag
Leu 516-expression tag
Ser 517-expression tag
Arg 518-expression tag
Ser 519-expression tag
Asp 520-expression tag
Leu 521-expression tag
Ser 522-expression tag
Lys 523-expression tag
Phe 524-expression tag
Arg 525-expression tag
Glu 526-expression tag
Asn 527-expression tag
Cys 528-expression tag
Lys 529-expression tag
Lys 530-expression tag
Arg 531-expression tag
Ala 532-expression tag
Met 533-expression tag
Ser 534-expression tag
Phe 535-expression tag
Ser 536-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight56162.5
Non-Polymers*Number of molecules3
Total formula weight987.4
All*Total formula weight57149.9
*Water molecules are not included.

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PDB entries from 2026-02-11

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