6TPK

Crystal structure of the human oxytocin receptor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004990	molecular_function	oxytocin receptor activity
A	0005000	molecular_function	vasopressin receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue NU2 A 1501

Chain	Residue
A	GLN92
A	ALA318
A	LYS116
A	GLN119
A	MET123
A	GLN171
A	ILE201
A	TRP288
A	PHE291
A	GLN295

---

site_id	AC2
Number of Residues	4
Details	binding site for residue CLR A 1502

Chain	Residue
A	PHE191
A	ILE192
A	TYR200
A	TRP203

---

site_id	AC3
Number of Residues	5
Details	binding site for residue PEG A 1503

Chain	Residue
A	GLU349
A	GLY354
A	ARG359
A	ARG383
A	LYS393

---

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASTyLLLLMSLDRCLaI

Chain	Residue	Details
A	ALA125-ILE141

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"32832646","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35241813","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35851571","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TPK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7QVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RYC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"32832646","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35241813","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35851571","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TPK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7QVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RYC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	40
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"32832646","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35241813","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35851571","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TPK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7QVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RYC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	30
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"32832646","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35241813","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35851571","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TPK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7QVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RYC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	13
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"32832646","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35241813","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35851571","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TPK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7QVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RYC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"32832646","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35241813","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35851571","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TPK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7QVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RYC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"32832646","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35241813","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35851571","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TPK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7QVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RYC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"32832646","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35241813","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35851571","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TPK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7QVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RYC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"32832646","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35241813","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35851571","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TPK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7QVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RYC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35241813","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RYC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32832646","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TPK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P70536","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---