6TPA
CDK8/CyclinC in complex with drug ETP-50775
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclin-dependent kinase 8 | polymer | 405 | 46962.8 | 1 | UniProt (P49336) Pfam (PF00069) | Homo sapiens (Human) | Cell division protein kinase 8,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Protein kinase K35 |
| 2 | B (B) | Cyclin-C | polymer | 285 | 33480.0 | 1 | UniProt (P24863) Pfam (PF00134) Pfam (PF16899) | Homo sapiens (Human) | SRB11 homolog,hSRB11 |
| 3 | C (A) | 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-3-(5-oxidanylidene-6-pyridin-4-yl-pyrido[2,3-b][1,5]benzoxazepin-9-yl)urea | non-polymer | 525.9 | 1 | Chemie (NZ8) | |||
| 4 | D, E, F, J, K... (A, B) | FORMIC ACID | non-polymer | 46.0 | 12 | Chemie (FMT) | |||
| 5 | G, H, I, S (A, B) | (2~{R})-butane-1,2-diol | non-polymer | 90.1 | 4 | Chemie (NZ5) | |||
| 6 | T, U (A, B) | water | water | 18.0 | 88 | Chemie (HOH) |
Sequence modifications
A: 1 - 403 (UniProt: P49336)
B: 1 - 283 (UniProt: P24863)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Lys 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Lys -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80442.7 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 1438.7 | |
| All* | Total formula weight | 81881.4 |
