6TP5
Crystal structure of human Transmembrane prolyl 4-hydroxylase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Transmembrane prolyl 4-hydroxylase | polymer | 421 | 48349.1 | 2 | UniProt (Q9NXG6) Pfam (PF13499) Pfam (PF13640) In PDB | Homo sapiens (Human) | P4H-TM,Hypoxia-inducible factor prolyl hydroxylase 4,HPH-4 |
| 2 | C, E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 3 | D | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1721.5 | 1 | In PDB GlyTouCan (G40702WU) | |||
| 4 | F | beta-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1721.5 | 1 | In PDB GlyTouCan (G46700WH) | |||
| 5 | A, B | N-OXALYLGLYCINE | non-polymer | 147.1 | 2 | Chemie (OGA) | |||
| 6 | A, B | FE (II) ION | non-polymer | 55.8 | 2 | Chemie (FE2) | |||
| 7 | A, B | TERTIARY-BUTYL ALCOHOL | non-polymer | 74.1 | 8 | Chemie (TBU) | |||
| 8 | A | GLYCINE | non-polymer | 75.1 | 2 | Chemie (GLY) | |||
| 9 | A, B | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 10 | A | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 11 | water | water | 18.0 | 135 | Chemie (HOH) |
Sequence modifications
A, B: 88 - 502 (UniProt: Q9NXG6)
| PDB | External Database | Details |
|---|---|---|
| His 82 | - | expression tag |
| His 83 | - | expression tag |
| His 84 | - | expression tag |
| His 85 | - | expression tag |
| His 86 | - | expression tag |
| His 87 | - | expression tag |
| Val 99 | Ala 99 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 96698.3 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 4291.9 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 1380.2 | |
| All* | Total formula weight | 102370.3 |
