6TJJ

Structure of Cerezyme at pH 4.6

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	AAA, BBB	Glucosylceramidase	polymer	497	55640.2	2	UniProt (P04062) Pfam (PF02055) Pfam (PF17189) In PDB	Homo sapiens (Human)	Acid beta-glucosidase,Alglucerase,Beta-glucocerebrosidase,Beta-GC,D-glucosyl-N-acylsphingosine glucohydrolase,Imiglucerase
2	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
3	BBB, AAA	SULFATE ION	non-polymer		96.1	18	Chemie (SO4)
4	BBB, AAA	ACETATE ION	non-polymer		59.0	16	Chemie (ACT)
5	BBB, AAA	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
6	BBB	POTASSIUM ION	non-polymer		39.1	1	Chemie (K)
7	BBB	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
8		water	water		18.0	715	Chemie (HOH)

Sequence modifications

AAA, BBB: 1 - 497 (UniProt: P04062)

PDB	External Database	Details
His 495	Arg 534	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	111280.3
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	38
	Total formula weight	3178.3
All*	Total formula weight	115307.5

*Water molecules are not included.