Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6TJJ

Structure of Cerezyme at pH 4.6

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0004336	molecular_function	galactosylceramidase activity
AAA	0004348	molecular_function	glucosylceramidase activity
AAA	0005102	molecular_function	signaling receptor binding
AAA	0005124	molecular_function	scavenger receptor binding
AAA	0005515	molecular_function	protein binding
AAA	0005615	cellular_component	extracellular space
AAA	0005764	cellular_component	lysosome
AAA	0005765	cellular_component	lysosomal membrane
AAA	0005783	cellular_component	endoplasmic reticulum
AAA	0005794	cellular_component	Golgi apparatus
AAA	0005802	cellular_component	trans-Golgi network
AAA	0006665	biological_process	sphingolipid metabolic process
AAA	0006678	biological_process	glucosylceramide metabolic process
AAA	0006680	biological_process	glucosylceramide catabolic process
AAA	0006914	biological_process	autophagy
AAA	0007005	biological_process	mitochondrion organization
AAA	0007040	biological_process	lysosome organization
AAA	0007417	biological_process	central nervous system development
AAA	0008203	biological_process	cholesterol metabolic process
AAA	0008340	biological_process	determination of adult lifespan
AAA	0008422	molecular_function	beta-glucosidase activity
AAA	0009267	biological_process	cellular response to starvation
AAA	0009268	biological_process	response to pH
AAA	0014004	biological_process	microglia differentiation
AAA	0016020	cellular_component	membrane
AAA	0016241	biological_process	regulation of macroautophagy
AAA	0016757	molecular_function	glycosyltransferase activity
AAA	0016787	molecular_function	hydrolase activity
AAA	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
AAA	0019882	biological_process	antigen processing and presentation
AAA	0019915	biological_process	lipid storage
AAA	0021694	biological_process	cerebellar Purkinje cell layer formation
AAA	0021859	biological_process	pyramidal neuron differentiation
AAA	0022904	biological_process	respiratory electron transport chain
AAA	0023021	biological_process	termination of signal transduction
AAA	0030259	biological_process	lipid glycosylation
AAA	0031175	biological_process	neuron projection development
AAA	0031333	biological_process	negative regulation of protein-containing complex assembly
AAA	0032006	biological_process	regulation of TOR signaling
AAA	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
AAA	0032715	biological_process	negative regulation of interleukin-6 production
AAA	0033077	biological_process	T cell differentiation in thymus
AAA	0033574	biological_process	response to testosterone
AAA	0035307	biological_process	positive regulation of protein dephosphorylation
AAA	0042391	biological_process	regulation of membrane potential
AAA	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
AAA	0043202	cellular_component	lysosomal lumen
AAA	0043243	biological_process	positive regulation of protein-containing complex disassembly
AAA	0043407	biological_process	negative regulation of MAP kinase activity
AAA	0043524	biological_process	negative regulation of neuron apoptotic process
AAA	0043627	biological_process	response to estrogen
AAA	0046512	biological_process	sphingosine biosynthetic process
AAA	0046513	biological_process	ceramide biosynthetic process
AAA	0046527	molecular_function	glucosyltransferase activity
AAA	0048469	biological_process	cell maturation
AAA	0048854	biological_process	brain morphogenesis
AAA	0048872	biological_process	homeostasis of number of cells
AAA	0050295	molecular_function	steryl-beta-glucosidase activity
AAA	0050728	biological_process	negative regulation of inflammatory response
AAA	0050877	biological_process	nervous system process
AAA	0050905	biological_process	neuromuscular process
AAA	0051246	biological_process	regulation of protein metabolic process
AAA	0051248	biological_process	negative regulation of protein metabolic process
AAA	0051402	biological_process	neuron apoptotic process
AAA	0061436	biological_process	establishment of skin barrier
AAA	0061518	biological_process	microglial cell proliferation
AAA	0061744	biological_process	motor behavior
AAA	0070062	cellular_component	extracellular exosome
AAA	0071356	biological_process	cellular response to tumor necrosis factor
AAA	0071425	biological_process	hematopoietic stem cell proliferation
AAA	0071548	biological_process	response to dexamethasone
AAA	0072676	biological_process	lymphocyte migration
AAA	0097066	biological_process	response to thyroid hormone
AAA	0098773	biological_process	skin epidermis development
AAA	1901805	biological_process	beta-glucoside catabolic process
AAA	1903052	biological_process	positive regulation of proteolysis involved in protein catabolic process
AAA	1903061	biological_process	positive regulation of protein lipidation
AAA	1904457	biological_process	positive regulation of neuronal action potential
AAA	1904925	biological_process	positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
AAA	1905037	biological_process	autophagosome organization
AAA	1905165	biological_process	regulation of lysosomal protein catabolic process
BBB	0004336	molecular_function	galactosylceramidase activity
BBB	0004348	molecular_function	glucosylceramidase activity
BBB	0005102	molecular_function	signaling receptor binding
BBB	0005124	molecular_function	scavenger receptor binding
BBB	0005515	molecular_function	protein binding
BBB	0005615	cellular_component	extracellular space
BBB	0005764	cellular_component	lysosome
BBB	0005765	cellular_component	lysosomal membrane
BBB	0005783	cellular_component	endoplasmic reticulum
BBB	0005794	cellular_component	Golgi apparatus
BBB	0005802	cellular_component	trans-Golgi network
BBB	0006665	biological_process	sphingolipid metabolic process
BBB	0006678	biological_process	glucosylceramide metabolic process
BBB	0006680	biological_process	glucosylceramide catabolic process
BBB	0006914	biological_process	autophagy
BBB	0007005	biological_process	mitochondrion organization
BBB	0007040	biological_process	lysosome organization
BBB	0007417	biological_process	central nervous system development
BBB	0008203	biological_process	cholesterol metabolic process
BBB	0008340	biological_process	determination of adult lifespan
BBB	0008422	molecular_function	beta-glucosidase activity
BBB	0009267	biological_process	cellular response to starvation
BBB	0009268	biological_process	response to pH
BBB	0014004	biological_process	microglia differentiation
BBB	0016020	cellular_component	membrane
BBB	0016241	biological_process	regulation of macroautophagy
BBB	0016757	molecular_function	glycosyltransferase activity
BBB	0016787	molecular_function	hydrolase activity
BBB	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
BBB	0019882	biological_process	antigen processing and presentation
BBB	0019915	biological_process	lipid storage
BBB	0021694	biological_process	cerebellar Purkinje cell layer formation
BBB	0021859	biological_process	pyramidal neuron differentiation
BBB	0022904	biological_process	respiratory electron transport chain
BBB	0023021	biological_process	termination of signal transduction
BBB	0030259	biological_process	lipid glycosylation
BBB	0031175	biological_process	neuron projection development
BBB	0031333	biological_process	negative regulation of protein-containing complex assembly
BBB	0032006	biological_process	regulation of TOR signaling
BBB	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
BBB	0032715	biological_process	negative regulation of interleukin-6 production
BBB	0033077	biological_process	T cell differentiation in thymus
BBB	0033574	biological_process	response to testosterone
BBB	0035307	biological_process	positive regulation of protein dephosphorylation
BBB	0042391	biological_process	regulation of membrane potential
BBB	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
BBB	0043202	cellular_component	lysosomal lumen
BBB	0043243	biological_process	positive regulation of protein-containing complex disassembly
BBB	0043407	biological_process	negative regulation of MAP kinase activity
BBB	0043524	biological_process	negative regulation of neuron apoptotic process
BBB	0043627	biological_process	response to estrogen
BBB	0046512	biological_process	sphingosine biosynthetic process
BBB	0046513	biological_process	ceramide biosynthetic process
BBB	0046527	molecular_function	glucosyltransferase activity
BBB	0048469	biological_process	cell maturation
BBB	0048854	biological_process	brain morphogenesis
BBB	0048872	biological_process	homeostasis of number of cells
BBB	0050295	molecular_function	steryl-beta-glucosidase activity
BBB	0050728	biological_process	negative regulation of inflammatory response
BBB	0050877	biological_process	nervous system process
BBB	0050905	biological_process	neuromuscular process
BBB	0051246	biological_process	regulation of protein metabolic process
BBB	0051248	biological_process	negative regulation of protein metabolic process
BBB	0051402	biological_process	neuron apoptotic process
BBB	0061436	biological_process	establishment of skin barrier
BBB	0061518	biological_process	microglial cell proliferation
BBB	0061744	biological_process	motor behavior
BBB	0070062	cellular_component	extracellular exosome
BBB	0071356	biological_process	cellular response to tumor necrosis factor
BBB	0071425	biological_process	hematopoietic stem cell proliferation
BBB	0071548	biological_process	response to dexamethasone
BBB	0072676	biological_process	lymphocyte migration
BBB	0097066	biological_process	response to thyroid hormone
BBB	0098773	biological_process	skin epidermis development
BBB	1901805	biological_process	beta-glucoside catabolic process
BBB	1903052	biological_process	positive regulation of proteolysis involved in protein catabolic process
BBB	1903061	biological_process	positive regulation of protein lipidation
BBB	1904457	biological_process	positive regulation of neuronal action potential
BBB	1904925	biological_process	positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
BBB	1905037	biological_process	autophagosome organization
BBB	1905165	biological_process	regulation of lysosomal protein catabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000269\|PubMed:15817452

Chain	Residue	Details
BBB	GLU235
AAA	GLU235

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000269\|PubMed:15817452

Chain	Residue	Details
BBB	GLU340
AAA	GLU340

site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:12792654, ECO:0000269\|PubMed:17139081

Chain	Residue	Details
AAA	ASN19
BBB	ASN19

site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:12754519, ECO:0000269\|PubMed:17139081, ECO:0000269\|PubMed:19159218

Chain	Residue	Details
AAA	ASN59
BBB	ASN59

site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:12754519, ECO:0000269\|PubMed:17139081

Chain	Residue	Details
AAA	ASN146
BBB	ASN146

site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:12754519, ECO:0000269\|PubMed:19159218

Chain	Residue	Details
AAA	ASN270
BBB	ASN270

site_id	SWS_FT_FI7
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
AAA	ASN462
BBB	ASN462

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 764

Chain	Residue	Details
AAA	GLU235	activator, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor
AAA	GLU340	covalently attached, nucleofuge, nucleophile
AAA	CYS342	electrostatic stabiliser
AAA	ASN370

site_id	MCSA2
Number of Residues	4
Details	M-CSA 764

Chain	Residue	Details
BBB	GLU235	activator, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor
BBB	GLU340	covalently attached, nucleofuge, nucleophile
BBB	CYS342	electrostatic stabiliser
BBB	ASN370

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)