6TEI

Crystal structure of human protein kinase CK2alpha (CSNK2A1 gene product) in complex with the 2-aminothiazole-type inhibitor 17

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Casein kinase II subunit alpha	polymer	349	41685.4	2	UniProt (P68400) Pfam (PF00069)	Homo sapiens (Human)	CK II alpha
2	C, E (A, B)	3-[(4-pyridin-2-yl-1,3-thiazol-2-yl)amino]benzoic acid	non-polymer		297.3	2	Chemie (N4N)
3	D, F, G (A, B)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
4	H, I (A, B)	water	water		18.0	385	Chemie (HOH)

Sequence modifications

A, B: 1 - 335 (UniProt: P68400)

PDB	External Database	Details
Met -13	-	initiating methionine
Gly -12	-	expression tag
Ser -11	-	expression tag
Ser -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Ser -3	-	expression tag
Gln -2	-	expression tag
Asp -1	-	expression tag
Pro 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	83370.9
Non-Polymers*	Number of molecules	5
	Total formula weight	882.9
All*	Total formula weight	84253.7

*Water molecules are not included.